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Ellen M. Gravallese, MD
Professor, Harvard Medical School
Theodore Bevier Bayles Professor of Medicine
Chief, Division of Rheumatology, Inflammation, and Immunity

Brigham and Women's Hospital
Department of Medicine
Rheumatology, Inflammation, and Immunity
75 Francis Street
Boston, MA 02115


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Research Narrative:

The Gravallese Laboratory is devoted to understanding the pathogenesis of inflammatory arthritis, including rheumatoid arthritis, spondyloarthritis, psoriatic arthritis and systemic lupus erythematosus. Our mission is to discover fundamental mechanisms of inflammation in these diseases and to dissect the impact of inflammation on bone. We study the onset, progression, persistence, and regulation of inflammation in these systemic rheumatic diseases using human tissues, murine models of disease and in-vitro assays, in order to contribute to the development of new clinical interventions. A new paradigm in the pathogenesis of autoimmune disease is the aberrant control of the innate immune system. In a recently added research area, we are focusing on cytosolic DNA sensing as an agent of the innate immune system. We have identified cytosolic DNA sensor pathways as playing an important role in autoimmunity and bone and focus on these pathways as well


Education:
Columbia University, 1981, MD
Harvard College, 1977, AB