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Ann Marie Egloff, PhD, MPH
Assistant Professor, Harvard Medical School

Brigham and Women's Hospital
Department of Surgery
75 Francis Street
Boston, MA 02115


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Research Narrative:

 

My primary research goal is to identify and develop, through translational research, better treatment and prevention strategies for head and neck cancers. My research has two general focuses: (1) defining patient and tumor molecular correlates and mechanisms of response/resistance to treatment and (2) developing and investigating relevant preclinical models in order to define important molecular contributors and effective treatment strategies. Important aspects of my research include developing and interrogating patient-derived xenografts, cancer cell lines and immune competent head and neck cancer models to elucidate cancer-specific signaling dependencies and mechanisms of immune evasion. This research is designed to explain how specific targeted therapies and immunotherpies work when they do, why they don’t work and what approaches should be pursued to improve treatment, thus advancing precision medicine through translational cancer research.