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Anne CC Lee, MD, MPH
Pediatrician, Brigham and Women's Hospital
Assistant Professor of Pediatrics, Harvard Medical School

Brigham and Women's Hospital
Department of Newborn Medicine
75 Francis Street
Boston, MA 02115

Research Location: Thorn Research Building

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Research Narrative:
My research focuses on global perinatal epidemiology and the design and evaluation of cost-effective interventions to reduce the major causes of neonatal mortality and morbidity. The objective of my research is to improve the prevention, management, and outcomes of preterm birth, “birth asphyxia,” and fetal growth restriction, particularly in low-and-middle income countries. I am currently engaged in the following projects: 1) evaluation of the impact of screening-and-treatment programs for maternal genitourinary tract infections on perinatal outcomes Sylhet Bangladesh; 2) development and validation of simplified methods of assessing infant maturity for first level health workers in low-resource settings in collaboration with the World Health Organization; 3) investigation of the vaginal microbiome and inflammatory responses associated with bacterial vaginosis infection and preterm birth; 4) estimation of the global burden of disease of fetal growth restriction and preterm birth and their risk factors; 5) estimation of the global burden of chronic impairment related to “birth asphyxia;” and 6) evaluation of the impact and cost effectiveness of community based interventions for birth asphyxia.


Publications (Pulled from Harvard Catalyst Profiles):

1. Lee AC, Mullany LC, Quaiyum M, Mitra DK, Labrique A, Christian P, Ahmed P, Uddin J, Rafiqullah I, DasGupta S, Rahman M, Koumans EH, Ahmed S, Saha SK, Baqui AH. Effect of population-based antenatal screening and treatment of genitourinary tract infections on birth outcomes in Sylhet, Bangladesh (MIST): a cluster-randomised clinical trial. Lancet Glob Health. 2019 01; 7(1):e148-e159.

2. Baqui AH, Lee ACC, Koffi AK, Khanam R, Mitra DK, Dasgupta SK, Uddin J, Ahmed P, Rafiqullah I, Rahman M, Quaiyum A, Koumans EH, Christian P, Saha SK, Mullany LC, Labrique A. Prevalence of and risk factors for abnormal vaginal flora and its association with adverse pregnancy outcomes in a rural district in north-east Bangladesh. Acta Obstet Gynecol Scand. 2019 Mar; 98(3):309-319.

3. Lee AC, Blencowe H, Lawn JE. Small babies, big numbers: global estimates of preterm birth. Lancet Glob Health. 2019 01; 7(1):e2-e3.

4. Khanam R, Lee AC, Mitra DK, Ram M, Das Gupta S, Quaiyum A, Choudhury A, Christian P, Mullany LC, Baqui AH. Maternal short stature and under-weight status are independent risk factors for preterm birth and small for gestational age in rural Bangladesh. Eur J Clin Nutr. 2019 May; 73(5):733-742.

5. Baqui A, Ahmed P, Dasgupta SK, Begum N, Rahman M, Islam N, Quaiyum M, Kirkwood B, Edmond K, Shannon C, Newton S, Hurt L, Jehan F, Nisar I, Hussain A, Nadeem N, Ilyas M, Zaidi A, Sazawal S, Deb S, Dutta A, Dhingra U, Ali SM, Hamer DH, Semrau KE, Straszak-Suri M, Grogan C, Bemba G, Lee AC, Wylie BJ, Manu A, Yoshida S, Bahl R. Development and validation of a simplified algorithm for neonatal gestational age assessment - protocol for the Alliance for Maternal Newborn Health Improvement (AMANHI) prospective cohort study. J Glob Health. 2017 Dec; 7(2):021201.

6. Lee AC, Panchal P, Folger L, Whelan H, Whelan R, Rosner B, Blencowe H, Lawn JE. Diagnostic Accuracy of Neonatal Assessment for Gestational Age Determination: A Systematic Review. Pediatrics. 2017 Dec; 140(6).

7. Lee AC, Kozuki N, Cousens S, Stevens GA, Blencowe H, Silveira MF, Sania A, Rosen HE, Schmiegelow C, Adair LS, Baqui AH, Barros FC, Bhutta ZA, Caulfield LE, Christian P, Clarke SE, Fawzi W, Gonzalez R, Humphrey J, Huybregts L, Kariuki S, Kolsteren P, Lusingu J, Manandhar D, Mongkolchati A, Mullany LC, Ndyomugyenyi R, Nien JK, Roberfroid D, Saville N, Terlouw DJ, Tielsch JM, Victora CG, Velaphi SC, Watson-Jones D, Willey BA, Ezzati M, Lawn JE, Black RE, Katz J. Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets. BMJ. 2017 Aug 17; 358:j3677.

8. Ariff S, Lee AC, Lawn J, Bhutta ZA. Global Burden, Epidemiologic Trends, and Prevention of Intrapartum-Related Deaths in Low-Resource Settings. Clin Perinatol. 2016 Sep; 43(3):593-608.

9. Lee AC, Mullany LC, Ladhani K, Uddin J, Mitra D, Ahmed P, Christian P, Labrique A, DasGupta SK, Lokken RP, Quaiyum M, Baqui AH. Validity of Newborn Clinical Assessment to Determine Gestational Age in Bangladesh. Pediatrics. 2016 07; 138(1).

10. Lee AC, Quaiyum MA, Mullany LC, Mitra DK, Labrique A, Ahmed P, Uddin J, Rafiqullah I, DasGupta S, Mahmud A, Koumans EH, Christian P, Saha S, Baqui AH. Screening and treatment of maternal genitourinary tract infections in early pregnancy to prevent preterm birth in rural Sylhet, Bangladesh: a cluster randomized trial. BMC Pregnancy Childbirth. 2015 Dec 07; 15:326.