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Michelle D. Holmes, MD, DPH
Associate Professor, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Channing Division of Network Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

My research interests include lifestyle factors (diet, weight change, physical activity, and psychosocial factors, common medications) affecting quality of life and survival after a breast cancer diagnosis, as well as the association between diet and breast cancer risk. Other research interests include diet and lifestyle influences on endogenous levels of steroid hormones and insulin-like growth factors, and ethnic differences in obesity and other lifestyle factors affecting chronic disease risk. I have worked with the Nurses’ Health Study since 1997.

I am the co-creator and co-Principal Investigator of the Africa/HSPH Partnership for Cohort Research and Training (PaCT) project. In this ambitious project modeled after Harvard’s Cohort studies, we plan to enroll 500,000 participants (60% women) across Nigeria, South Africa, Uganda, Tanzania to study and prevent the chronic disease tsunami (high blood pressure, cancer, diabetes) about to overwhelm HIV, TB, and malaria in Africa. I have recruited collaborative teams of 5-7 people at each of 5 African centers of excellence and organized pilot studies at each site. I have organized 4 all- collaborator meetings, in South Africa, Tanzania, Greece, and Sweden. I have also organized 2 global integration meetings with similar cohorts from Mexico, India, and Sweden held in Hydra Greece 2010 and Sigtuna Sweden 2012.