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John Weyl Winkelman, MD, PhD
Associate Physician, Brigham and Women's Hospital
Professor of Psychiatry, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Sleep Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

Dr. Winkelman is board-certified in Sleep Disorders Medicine and Psychiatry and has performed both clinical work and research in these specialties for 30 years. He is Chief of the Sleep Disorders Clinical Research Program in the Department of Psychiatry at MGH where his clinical work in sleep disorders involves patients at the interface of psychiatry, neurology, and medicine and employs an interdisciplinary therapeutic approach. He is nationally recognized for his expertise in sleep disorders and sees many local, regional, and national referrals for complex sleep-disordered patients. He teaches residents and fellows at many Harvard-affiliated hospitals and is the editor of the textbook Foundations of Psychiatric Sleep Medicine (Cambridge University Press, 2010). He has also made clinical guideline contributions on Insomnia Disorder (New England Journal of Medicine, 2015; UpToDate), Restless Legs Syndrome (RLS) (Sleep Medicine, 2014, 2015, 2016, 2017; Neurology, 2017; Movement Disorders, 2018) and mood disorders in sleep disorders (e.g., multiple textbook chapters, Sleep Medicine Clinics, 2015, JAMA Psychiatry, 2019, Neuropsychopharmacology, 2020).

 Dr. Winkelman is also an established researcher in the area of sleep. He has been the Principal Investigator for many clinical trials that have used sleep endpoints as primary outcomes and has been a Co-Investigator on numerous additional studies for which he has provided expertise regarding the measurement or analysis of sleep. He has had funding from foundations, industry, and NIH. Dr. Winkelman has extensive experience investigating genetic, epidemiologic, neuroimaging, cardiovascular physiology, and sleep-related endpoints in patients with RLS and was senior author on published pivotal trials for FDA approval of pramipexole and gabapentin enacarbil. He also has specific experience assessing the relationship of mood and sleep disorders using objective sleep, morphometric and magnetic resonance spectroscopy (MRS) outcomes in patients with depression and primary insomnia. He has mentored many residents and fellows in sleep disorders research and has substantial expertise in selecting appropriate measures to assess CNS function relevant to movement, sleep and mood. Since 2019 he has been Chair of the International Restless Legs Syndrome Study Group.  He has numerous original publications in peer-reviewed journals, including Biological Psychiatry, the American Journal of Psychiatry, Neurology, and the New England Journal of Medicine.

Harvard School of Medicine, 1987, MD
Harvard Graduate School of Arts and Sciences, 1983, PhD