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John Weyl Winkelman, MD, PhD
Associate Physician, Brigham and Women's Hospital
Professor of Psychiatry, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Sleep Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

My research involves study of patients with restless legs syndrome (RLS), insomnia, mood disorders, and sleep-related eating disorders.  In RLS, we are doing 3 separate clinical trials for potential and approved medications for the disorder, investigating rotigitine for ESRD-related RLS as well as its ability to treat daytime symptoms in primary RLS, and a novel medication for primary RLS.  We are also beginning a study of cardiovascular control in RLS given our data that the disorder is associated with cardiovascular disease.  My RO1 investigates spectroscopically-derived GABA levels in patients with major depression with and without insomnia, those with primary insomnia, and those without either depression or insomnia.  Secondary outcomes involve objectively recorded sleep and functional and structural MRI.  Finally, other studies involve outcomes in patients with periodic limb movements of sleep and medication treatment of sleep-related eating disorder.

Harvard School of Medicine, 1987, MD
Harvard Graduate School of Arts and Sciences, 1983, PhD