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Simon Christopher Body, MD MPH
Anesthesiologist, Brigham and Women's Hospital
Associate Professor of Anaesthesia, Harvard Medical School

Brigham and Women's Hospital
Department of Anesthesiology, Perioperative and Pain Medicine
75 Francis Street
Boston, MA 02115

Research Location: Thorn Research Building

Phone: (508) 732-8210
Fax: (617) 732-6798
Email: sbody@partners.org
Research Email: sbody@partners.org

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Research Narrative:

In 2000, I initiated and have led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with my co-investigators at BWH (Drs. Shernan, Fox, Muehlschlegel, Perry, Liu) and Texas Heart Institute (Dr. Collard) and collaborators at Duke and Vanderbilt we have spent the last eight years collecting over 2200 patients who have undergone primary CABG as the substrate for this research. We are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation, myocardial infarction, ventricular dysfunction and bleeding. This research is being funded by a grant from the Department of Anesthesiology, Perioperative and Pain Medicine Research Fund, previously by my K-23 grant from the NHLBI and up-coming R01 funding from NHLBI. In the last year, we have had papers specifically related to these areas published or accepted in Circulation:Cardiovascular Genetics, the Journal of Cardiothoracic and Vascular Surgery, Anesthesia and Analgesia, BMC Genetics and Anesthesiology. In addition, along with colleagues at HMS (Drs. C. and J. Seidman), BWH (Drs. Bolman, Shernan, and Tischler), MGH (Drs. Slaugenhaupt and Levine) I am researching the genetic causes of bicuspid aortic valve disease. We are collecting patients who have undergone or are undergoing surgery for BAV in order to derive associations between whole-genome exomal and genome variants and BAV.


Education:
HSPH, 2004, MPH
MD

Honors/Awards:
Fellow of the American Heart Association

Publications (Pulled from Harvard Catalyst Profiles):

1. Fulmer D, Toomer K, Guo L, Moore K, Glover J, Moore R, Stairley R, Lobo G, Zuo X, Dang Y, Su Y, Fogelgren B, Gerard P, Chung D, Heydarpour M, Mukherjee R, Body SC, Norris RA, Lipschutz JH. Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis. Circulation. 2019 Aug 07.

2. Kaneko T, Hirji S, Percy E, Aranki S, McGurk S, Body S, Heydarpour M, Mallidi H, Singh S, Pelletier M, Rawn J, Shekar P. Characterizing Risks Associated with Mitral Annular Calcification in Mitral Valve Replacement. Ann Thorac Surg. 2019 Jun 14.

3. Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA. Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 May 22; 11(493).

4. Stone G, Choi A, Meritxell O, Gorham J, Heydarpour M, Seidman CE, Seidman JG, Aranki SF, Body SC, Carey VJ, Raby BA, Stranger BE, Muehlschlegel JD. Sex differences in gene expression in response to ischemia in the human left ventricular myocardium. Hum Mol Genet. 2019 May 15; 28(10):1682-1693.

5. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49.

6. Shah RM, Hirji SA, Jolissaint JS, Lander HL, Shah PB, Pelletier MP, Sobieszczyk PS, Berry NC, Shook DC, Nyman CB, Bhatt DL, Body S, Kaneko T. Comparison of Sex-Based Differences in Home or Nonhome Discharge Utilization of Rehabilitative Services and Outcomes Following Transcatheter Aortic Valve Implantation in the United States. Am J Cardiol. 2019 Jun 15; 123(12):1983-1991.

7. Dayan V, Zuasnabar A, Citro R, Bossone E, Michelena HI, Parma G, Bellino M, Olascoaga A, Florio L, Body S. Aortopathy and regurgitation in bicuspid valve patients increase the risk of aortopathy in relatives. Int J Cardiol. 2019 Jul 01; 286:117-120.

8. Zuo X, Lobo G, Fulmer D, Guo L, Dang Y, Su Y, Ilatovskaya DV, Nihalani D, Rohrer B, Body SC, Norris RA, Lipschutz JH. The exocyst acting through the primary cilium is necessary for renal ciliogenesis, cystogenesis, and tubulogenesis. J Biol Chem. 2019 Apr 26; 294(17):6710-6718.

9. Muehlschlegel JD, Burrage PS, Ngai JY, Prutkin JM, Huang CC, Xu X, Chae SH, Bollen BA, Piccini JP, Schwann NM, Mahajan A, Ruel M, Body SC, Sellke FW, Mathew J, O'Brien B. Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery. Anesth Analg. 2019 Jan; 128(1):33-42.

10. O'Brien B, Burrage PS, Ngai JY, Prutkin JM, Huang CC, Xu X, Chae SH, Bollen BA, Piccini JP, Schwann NM, Mahajan A, Ruel M, Body SC, Sellke FW, Mathew J, Muehlschlegel JD. Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019 Jan; 33(1):12-26.