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Shuichi Mizuno, PhD
Scientist, Brigham and Women's Hospital
Associate Professor of Orthopedic Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Orthopedic Surgery
75 Francis Street
Boston, MA 02115

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Research Narrative:

Investigative Interests: Tissue Engineering, mechnophysiology, physiome


Publications (Pulled from Harvard Catalyst Profiles):

1. Ogura T, Minas T, Tsuchiya A, Mizuno S. Effects of hydrostatic pressure and deviatoric stress on human articular chondrocytes for designing neo-cartilage construct. J Tissue Eng Regen Med. 2019 Jul; 13(7):1143-1152.

2. Mizuno S, Kashiwa K, Kang JD. Molecular and histological characteristics of bovine caudal nucleus pulposus by combined changes in hydrostatic and osmotic pressures in vitro. J Orthop Res. 2019 Feb; 37(2):466-476.

3. Takada E, Mizuno S. Reproduction of Characteristics of Extracellular Matrices in Specific Longitudinal Depth Zone Cartilage within Spherical Organoids in Response to Changes in Osmotic Pressure. Int J Mol Sci. 2018 May 18; 19(5).

4. Ogura T, Tsuchiya A, Minas T, Mizuno S. Optimization of Extracellular Matrix Synthesis and Accumulation by Human Articular Chondrocytes in 3-Dimensional Construct with Repetitive Hydrostatic Pressure. Cartilage. 2018 04; 9(2):192-201.

5. Mizuno S, Takada E, Fukai N. Spheroidal Organoids Reproduce Characteristics of Longitudinal Depth Zones in Bovine Articular Cartilage. Cells Tissues Organs. 2016; 202(5-6):382-392.

6. Ogura T, Tsuchiya A, Minas T, Mizuno S. Methods of high integrity RNA extraction from cell/agarose construct. BMC Res Notes. 2015 Nov 04; 8:644.

7. Ogawa R, Orgill DP, Murphy GF, Mizuno S. Hydrostatic pressure-driven three-dimensional cartilage induction using human adipose-derived stem cells and collagen gels. Tissue Eng Part A. 2015 Jan; 21(1-2):257-66.

8. Tatsumura M, Sakane M, Ochiai N, Mizuno S. Off-loading of cyclic hydrostatic pressure promotes production of extracellular matrix by chondrocytes. Cells Tissues Organs. 2013; 198(6):405-13.

9. Glowacki J, Mizuno S, Kung J, Goff J, Epperly M, Dixon T, Wang H, Greenberger JS. Effects of mouse genotype on bone wound healing and irradiation-induced delay of healing. In Vivo. 2014 Mar-Apr; 28(2):189-96.

10. Zhou S, Mizuno S, Glowacki J. Wnt pathway regulation by demineralized bone is approximated by both BMP-2 and TGF-ß1 signaling. J Orthop Res. 2013 Apr; 31(4):554-60.