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Scott Tillman Weiss, MD
Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Channing Division of Network Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

I am currently Director of Respiratory, Environmental, and Genetic Epidemiology at the Channing Laboratory, and Professor of Medicine at Harvard Medical School. In this capacity, I lead a 30-investigator, 110-person research group involved in examining the environmental exposures and genetic risk factors for the development of asthma and COPD. I am responsible for the administrative aspects of this program in respiratory and genetic epidemiology, as well as my own research. My laboratory has close working relationships with the Department of Environmental Health at the Harvard School of Public Health where I am a Professor of Environmental Health (Respiratory Biology Program), the Pulmonary Division at Brigham and Women’s Hospital and the Partners Center for Personalized Genetic Medicine (PCPGM) where I am currently the Director. I lead a 100 person group at the Partners Center who are focused on translational genomics. I have led multidisciplinary cooperative studies of asthma and COPD and I have international research experience in China, Norway, Mexico, England, Costa Rica, and the Netherlands. I am also Principal Investigator of the only training program in the Clinical and Genetic Epidemiology of Lung Diseases (T32 HL007427).

I have collaborated with a variety of investigators on cooperative studies such as the Childhood Asthma Management Program (CAMP), SHARE and EVE, and has served in an administrative capacity with the NHLBI for a variety of genetic epidemiologic programs including the Special Emphasis Panel on the Use of NHLBI Specimens, the Oversight Committee for the Collaborative Study on the Genetics of Asthma, the NHLBI Genotyping Service Study Section and the oversight panel for the Genotyping and Sequencing Service. I recently finished service on the T32 training grant review study section. I have authored or co-authored over 600 papers and co-written and co-edited four books, including a comprehensive textbook of Respiratory Genetics.

My long-standing research interests have been in the area of environmental and genetic risk factors for the development of asthma and chronic obstructive pulmonary disease (COPD). My initial work concerned the role of environmental tobacco smoke exposure in the development of asthma. I then studied the effect of airway responsiveness in populations on the development and natural history of asthma and COPD development. In 1996, I developed a strong interest in the genetics of asthma. By 2000 I was fully funded to pursue research in this area and now devote most of my research time to asthma genetics and genomics. A particular interest is translational genomics or predictive medicine, using genetic markers to better predict drug treatment response and disease outcomes. I have mentored 33 trainees over the past 25 years, all of whom still remain in academia.

Case Western Reserve University School of Medicine , 1972, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Rago D, Rasmussen MA, Lee-Sarwar KA, Weiss ST, Lasky-Su J, Stokholm J, Bønnelykke K, Chawes BL, Bisgaard H. Fish-oil supplementation in pregnancy, child metabolomics and asthma risk. EBioMedicine. 2019 Aug 06.

2. Sumathipala M, Maiorino E, Weiss ST, Sharma A. Network Diffusion Approach to Predict LncRNA Disease Associations Using Multi-Type Biological Networks: LION. Front Physiol. 2019; 10:888.

3. Zhang J, Can A, Mukundan S, Steigner M, Castro VM, Dligach D, Finan S, Yu S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Wang Z, Weiss ST, Du R. Morphological Variables Associated With Ruptured Middle Cerebral Artery Aneurysms. Neurosurgery. 2019 Jul 01; 85(1):75-83.

4. Kachroo P, Kelly RS, Mirzakhani H, Lee-Sarwar K, Chawes BL, Blighe K, Davaasambuu G, Bisgaard H, Litonjua AA, Weiss ST, Lasky-Su J. Fish oil supplementation during pregnancy is protective against asthma/wheeze in offspring. J Allergy Clin Immunol Pract. 2019 Jun 19.

5. Wang AL, Gruzieva O, Qiu W, Merid SK, Celedón JC, Raby BA, Söderhäll C, DeMeo DL, Weiss ST, Melén E, Tantisira KG. DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics. Clin Exp Allergy. 2019 Jun 12.

6. Du R, Carey V, Weiss S. deconvSeq: Deconvolution of Cell Mixture Distribution in Sequencing Data. Bioinformatics. 2019 May 30.

7. Mirzakhani H, Carey VJ, McElrath TF, Hollis BW, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST. Maternal Asthma, Preeclampsia and Risk of Childhood Asthma at Age Six. Am J Respir Crit Care Med. 2019 May 06.

8. Ierodiakonou D, Coull BA, Zanobetti A, Postma DS, Boezen HM, Vonk JM, McKone EF, Schildcrout JS, Koppelman GH, Croteau-Chonka DC, Lumley T, Koutrakis P, Schwartz J, Gold DR, Weiss ST. Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children. J Expo Sci Environ Epidemiol. 2019 Jun; 29(4):539-547.

9. Can A, Lai PMR, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R. Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms. Sci Rep. 2019 Apr 15; 9(1):6054.

10. Sonawane AR, Weiss ST, Glass K, Sharma A. Network Medicine in the Age of Biomedical Big Data. Front Genet. 2019; 10:294.