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Thomas Peter Stossel
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Emeritus, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Translational Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

My basic research interest concerns the structure and function of the essential actin-binding and scaffolding protein filamin A, defining its role in cell mechanics and in the integration of cell signaling reactions. We are developing filamin A reagents to permit examining its actin cross-linking and partnering functions with over 200 cellular components in isolation. In this effort we collaborate with Dr David Weitz, Department of Applied Physics, Harvard University, Dr Matthew Lang, Bioengineering Department, Massachusetts Institute of Technology, and with Dr Jari Ylänne of the Protein Structure Department in the University of Jvyäskyla, Finland and with other investigators around the world who study specific filamin A binding-partners.

I collaborate with Dr Po-Shun Lee, Pulmonary Division, Brigham & Women’s Hospital on understanding the physiological role of plasma gelsolin, an abundant circulating isoform of a cellular actin-binding protein I discovered in 1979. Plasma gelsolin depletion precedes and predicts critical care complications in humans, and repletion of plasma gelsolin reduces mortality in animal sepsis models. I am the scientific founder of a company, Critical Biologics Corporation, that is testing the utility of plasma gelsolin as a “theranostic” (diagnostic and therapeutic) agent in human diseases.

My policy interest is to better understand and facilitate interactions between physicians, academic researchers and private companies, and to educate medical students and practitioners concerning the role of markets in medicine. To further this work, I have been appointed Senior Fellow of the Manhattan Institute for Policy Research.

I have established a sickle cell disease clinical and research center in collaboration with physicians at University Teaching Hospital, University of Zambia, Lusaka Zambia (

Publications (Pulled from Harvard Catalyst Profiles):

1. Yang Z, Bedugnis A, Levinson S, DiNubile M, Stossel T, Lu Q, Kobzik L. Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Sensitive and Resistant Pneumococcal Pneumonia. J Infect Dis. 2019 Jul 09.

2. Self WH, Wunderink RG, DiNubile MJ, Stossel TP, Levinson SL, Williams DJ, Anderson EJ, Bramley AM, Jain S, Edwards KM, Grijalva CG. Low Admission Plasma Gelsolin Concentrations Identify Community-acquired Pneumonia Patients at High Risk for Severe Outcomes. Clin Infect Dis. 2018 Dec 17.

3. Chunda-Liyoka C, Kumar AA, Sambo P, Lubinda F, Nchimba L, Humpton T, Okuku P, Miyanda C, Im J, Maguire K, Whitesides GM, Stossel TP. Application of a public health strategy to large-scale point-of-care screening for sickle cell disease in rural sub-Saharan Africa. Blood Adv. 2018 11 30; 2(Suppl 1):1-3.

4. Stossel TP. A guide to the anti-innovation "pharmaphobia" narrative for the aspiring innovator. Surgery. 2017 02; 161(2):305-307.

5. Nadkarni NA, Rajakumar A, Mokhashi N, Burke SD, Rana S, Salahuddin S, Dang Q, Thadhani R, Krishnan R, Stossel TP, Karumanchi SA. Gelsolin is an endogenous inhibitor of syncytiotrophoblast extracellular vesicle shedding in pregnancy. Pregnancy Hypertens. 2016 Oct; 6(4):333-339.

6. Barton D, Stossel TP. Pediatric Dentists' Knowledge Concerning the Physician Payments Sunshine Act and Their Predictions of its Effects on Their Interactions with the Industry and its Impact on Patient Care. Pediatr Dent. 2016 Mar-Apr; 38(2):122-6.

7. Song M, He Q, Berk BA, Hartwig JH, Stossel TP, Nakamura F. An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). Biochem Biophys Res Commun. 2016 Jan 15; 469(3):659-64.

8. Li-ChunHsieh K, Schob S, Zeller MW, Pulli B, Ali M, Wang C, Chiou TT, Tsang YM, Lee PS, Stossel TP, Chen JW. Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis. J Neuroimmunol. 2015 Oct 15; 287:36-42.

9. Yang Z, Chiou TT, Stossel TP, Kobzik L. Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 01; 309(1):L11-6.

10. Kumar AA, Hennek JW, Smith BS, Kumar S, Beattie P, Jain S, Rolland JP, Stossel TP, Chunda-Liyoka C, Whitesides GM. From the bench to the field in low-cost diagnostics: two case studies. Angew Chem Int Ed Engl. 2015 May 11; 54(20):5836-53.