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Frank A. J. L. Scheer, PhD, MSc
Neuroscientist, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Sleep Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

My lab is focused on the influence of the endogenous circadian system and its disruption—such as with shift work—on cardiovascular, pulmonary, and metabolic regulation and disease states, including hypertension, asthma, obesity and diabetes. This, primarily, basic and translational human research is aimed both at the physiological mechanisms and therapeutic strategies of medical chronobiology.

I have co-founded and currently direct the Medical Chronobiology Program (MCP), an interdisciplinary research program at Brigham and Women's Hospital (BWH) to foster the translational research in sleep and circadian biology to understand the basis behind time-variant changes in disease severity, the effects of circadian misalignment (typical in night shift workers), and their interaction with genetics (e.g., the common MTNR1B variant).

Understanding the biological basis of these changes across the day and night and their interaction with genetics may help in the development of personalized and time-based behavioral, environmental, and pharmaceutical interventions (e.g. appropriately timed meals, exercise or melatonin to target specific phases of the body clock) to prevent, treat, and/or manage disease.

Circadian Rhythms and Your Health Video - Brigham and Women's Hospital

University of Amsterdam, 2003, PhD
Utrecht University, 1997, MSc

Pickwick Postdoctoral Fellowship, National Sleep Foundation (2005)
Young Investigator Neurology Section Award, American Academy of Sleep Medicine (2005)
Young Investigator Award, American Academy of Sleep Medicine (2007)
1st Place Clinical Research Young Investigator Award, National Sleep Foundation/Sleep Research Society (2008)
Neal Miller Award, Academy of Behavioral Medicine Research (2009)
Young Investigator Award, Honorable Mention, Sleep Research Society (2010)
Outstanding Scientific Achievement Award, Sleep Research Society (2019)

Courses Taught:
Gen Ed 1038, Sleep, Harvard College, 2019-

MCB 186, Sleep and Circadian Clocks: from Biology to Public Health, Harvard College, 2017-