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Steven W. Lockley, Ph.D.
Associate Neuroscientist, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Sleep Medicine
75 Francis Street
Boston, MA 02115


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Research Narrative:

The Circadian Physiology Program focuses on basic and applied aspects of human circadian biology. Our translational approach includes use of a range of techniques including epidemiology, field-based physiological studies and inpatient intensive physiological monitoring. We have a particular interest in human circadian photoreception and the effects of light on the circadian pacemaker and other non-image forming responses. Our studies include investigations of the effects of timing, duration, intensity and wavelength of light exposure on circadian resetting, melatonin suppression and the acute alerting effects of light. We also study visually impaired individuals under field and laboratory conditions to examine the effects of the severity and type of blindness on circadian photoreception, the periodicity of the circadian pacemaker and development of circadian rhythm sleep disorders. These basic studies have led to the development of novel therapeutic strategies to treat non-24-hour sleep wake disorder, Advanced- and Delayed Sleep Phase Syndrome with appropriately-timed melatonin administration in blind patients. We have also recently begun to examine the role of visual impairment on endocrinology and breast cancer risk in blind women.

With the Harvard Work Hours Health and Safety Group, we assess the impact of extended work hours on health and safety of workers and the public. Our studies include the development of interventions that reduce extended duration work hours, fatigue and medical errors in hospital residents, and the implementation of large-scale occupational fatigue management and sleep disorders screening programs in several police forces nationwide.


Education:
Surrey University, Guildford, England, 1997, Ph.D.

Publications (Pulled from Harvard Catalyst Profiles):

1. Barger LK, Sullivan JP, Blackwell T, O'Brien CS, St Hilaire MA, Rahman SA, Phillips AJK, Qadri S, Wright KP, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee P, Sanderson AL, Halbower AC, Lockley SW, Landrigan CP, Stone KL, Czeisler CA. Effects on resident work hours, sleep duration, and work experience in a randomized order safety trial evaluating resident-physician schedules (ROSTERS). Sleep. 2019 Aug 01; 42(8).

2. Stone JE, Aubert XL, Maass H, Phillips AJK, Magee M, Howard ME, Lockley SW, Rajaratnam SMW, Sletten TL. Application of a Limit-Cycle Oscillator Model for Prediction of Circadian Phase in Rotating Night Shift Workers. Sci Rep. 2019 Jul 30; 9(1):11032.

3. Stone JE, Phillips AJK, Ftouni S, Magee M, Howard M, Lockley SW, Sletten TL, Anderson C, Rajaratnam SMW, Postnova S. Generalizability of A Neural Network Model for Circadian Phase Prediction in Real-World Conditions. Sci Rep. 2019 Jul 29; 9(1):11001.

4. Spitschan M, Stefani O, Blattner P, Gronfier C, Lockley SW, Lucas RJ. How to Report Light Exposure in Human Chronobiology and Sleep Research Experiments. Clocks Sleep. 2019 Jul 01; 1(3):280-289.

5. Mulhall MD, Sletten TL, Magee M, Stone JE, Ganesan S, Collins A, Anderson C, Lockley SW, Howard ME, Rajaratnam SMW. Sleepiness and driving events in shift workers: the impact of circadian and homeostatic factors. Sleep. 2019 Jun 11; 42(6).

6. Booker LA, Sletten TL, Alvaro PK, Barnes M, Collins A, Chai-Coetzer CL, Naqvi A, McMahon M, Lockley SW, Rajaratnam SMW, Howard ME. Exploring the associations between shift work disorder, depression, anxiety and sick leave taken amongst nurses. J Sleep Res. 2019 May 29; e12872.

7. Razavi P, Devore EE, Bajaj A, Lockley SW, Figueiro MG, Ricchiuti V, Gauderman WJ, Hankinson SE, Willett WC, Schernhammer ES. Shift Work, Chronotype, and Melatonin Rhythm in Nurses. Cancer Epidemiol Biomarkers Prev. 2019 Jul; 28(7):1177-1186.

8. Phillips AJK, Vidafar P, Burns AC, McGlashan EM, Anderson C, Rajaratnam SMW, Lockley SW, Cain SW. High sensitivity and interindividual variability in the response of the human circadian system to evening light. Proc Natl Acad Sci U S A. 2019 Jun 11; 116(24):12019-12024.

9. Wolkow AP, Barger LK, O'Brien CS, Sullivan JP, Qadri S, Lockley SW, Czeisler CA, Rajaratnam SMW. Associations between sleep disturbances, mental health outcomes and burnout in firefighters, and the mediating role of sleep during overnight work: A cross-sectional study. J Sleep Res. 2019 May 26; e12869.

10. St Hilaire MA, Anderson C, Anwar J, Sullivan JP, Cade BE, Flynn-Evans EE, Czeisler CA, Lockley SW. Brief (<4 hr) sleep episodes are insufficient for restoring performance in first-year resident physicians working overnight extended-duration work shifts. Sleep. 2019 May 01; 42(5).