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Elizabeth B. Klerman, MD, PhD
Associate Physician, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Sleep Medicine
75 Francis Street
Boston, MA 02115

Research Location: Richardson Fuller


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Research Narrative:

Dr Klerman's current research focuses on the areas of:

  • the interaction of endocrine, circadian and sleep rhythms in normal and pathological states and
  • mathematical modeling and analyses of sleep, circadian rhythms and markers of its function.
Dr. Klerman is Director of the Analytic Modeling Unit within the Division of Sleep and Circadian Disorders at BWH. She collaborates with investigators from other Divisions to apply the principles of circadian rhythms research to the study of human physiology and pathophysiology.  Members of the Analytic and Modeling Unit systematically and mathematically explore many aspects of the sleep and circadian rhythms. The results have implications for the design and analysis of future circadian experiments as well as reinterpretation of earlier studies. This work is part of a cycle of experimental work- mathematical modeling and predictions- experimental work. This Unit's projects have included:
 
  • the effects of different patterns of light exposure on observed circadian rhythms,
  • a reanalysis of data to demonstrate that a method of analysisfrequently used in circadian rhythm research yields inaccurate results,
  • an analysis of three markers of the circadian system for sources ofvariability, providing quantitative assessment of their relativeaccuracy as markers of circadian rhythms,
  • development and application of a physiologically based model of growth hormone secretion with Dr. Emery Brown of MGH and MIT,
  • development of new techniques for quantifying sleep architecture andits changes with aging and after pharmacological intervention, and 
  • mathematical simulations of models of human circadian rhythms, alertness and performance and optimization of countermeasure design.

Dr. Klerman also mentors undergraduates, graduate students, fellows and junior fellows in clinical research. She has a NIH K24 award to support this work and has worked with the Harvard Catalyst and BWH programs for career advancement in clinical research. She is also an HMS Research Fellow in the Holmes Society.


Education:
Harvard Medical School, 1990, MD
Harvard Graduate School of Arts & Sciences, 1990, PhD

Publications (Pulled from Harvard Catalyst Profiles):

1. Kronauer RE, St Hilaire MA, Rahman SA, Czeisler CA, Klerman EB. An Exploration of the Temporal Dynamics of Circadian Resetting Responses to Short- and Long-Duration Light Exposures: Cross-Species Consistencies and Differences. J Biol Rhythms. 2019 Aug 01; 748730419862702.

2. Roenneberg T, Wirz-Justice A, Skene DJ, Ancoli-Israel S, Wright KP, Dijk DJ, Zee P, Gorman MR, Winnebeck EC, Klerman EB. Why Should We Abolish Daylight Saving Time? J Biol Rhythms. 2019 Jun; 34(3):227-230.

3. Schwartz WJ, Klerman EB. Circadian Neurobiology and the Physiologic Regulation of Sleep and Wakefulness. Neurol Clin. 2019 Aug; 37(3):475-486.

4. McHill AW, Hull JT, Cohen DA, Wang W, Czeisler CA, Klerman EB. Chronic sleep restriction greatly magnifies performance decrements immediately after awakening. Sleep. 2019 May 01; 42(5).

5. Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena R. Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans. Sci Rep. 2019 Mar 29; 9(1):5350.

6. McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, Scheer FAJL, Klerman EB. Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults. Nutrients. 2019 03 11; 11(3).

7. Rahman SA, Bibbo C, Olcese J, Czeisler CA, Robinson JN, Klerman EB. Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy. J Pineal Res. 2019 May; 66(4):e12566.

8. Gu F, Klerman EB, Kim S, Moore S, Yu K, Albert PS, Caporaso NE. Diurnal variation of metabolites in three individual participants. Chronobiol Int. 2019 Mar; 36(3):332-342.

9. Weaver MD, Barger LK, Malone SK, Anderson LS, Klerman EB. Dose-Dependent Associations Between Sleep Duration and Unsafe Behaviors Among US High School Students. JAMA Pediatr. 2018 Dec 01; 172(12):1187-1189.

10. Schneider J, Saenz-Otero A, Klerman E, Stirling L. Strategy Development Pilot Study of Sleep-Restricted Operators Using Small Satellites with Displays. Aerosp Med Hum Perform. 2018 12 01; 89(12):1036-1044.