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JoAnn Elisabeth Manson, MD. DrPH
Physician, Brigham and Women's Hospital
Michael and Lee Bell Professor of Women's Health, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Preventive Medicine
75 Francis Street
Boston, MA 02115

Research Location: 900-930 Commonwealth Avenue


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Research Narrative:

The focus of Dr. Manson’s research has been women's health, randomized clinical trials in cardiovascular disease prevention, and population health/translational research.  She has studied the role of lifestyle factors, diet, micronutrient supplementation, and reproductive and hormonal factors as predictors of chronic disease in women.  Other major interests include the role of vitamin D, omega-3s, and folate in the prevention of CVD, diabetes, and cancer. She has studied extensively the role of moderate-intensity exercise as compared with vigorous exercise in the prevention of heart disease, stroke, type 2 diabetes, and breast cancer in women.  She has also been actively involved in studies of biomarker and genetic predictors of cardiovascular disease and diabetes.  She is one of the lead investigators on several landmark women’s health studies, including the Women’s Health Initiative, the Nurses’ Health Study, the Women’s Antioxidant and Folic Acid Cardiovascular Study, and others. 


Honors/Awards:
“Woman in Science” Award from the American Medical Women’s Association in 2003, election to membership in the Association of American Physicians in 2005, the Harvard College Women’s Professional Achievement Award in 2006, fellowship in the American Association for the Advancement of Science (AAAS) in 2007, the American Heart Association’s Population Research Prize in 2010 and Distinguished Scientist Award in 2011, election to the Institute of Medicine (IOM) in 2011.

Publications (Pulled from Harvard Catalyst Profiles):

1. Jiang X, Nudy M, Aragaki AK, Robbins JA, Manson JE, Stefanick ML, O'Sullivan DM, Shikany JM, LeBlanc ES, Kelsey AM, Cauley J, Martin LW, Payne ME, Johnson KC, Howard B, Schnatz PF. Women's Health Initiative clinical trials: potential interactive effect of calcium and vitamin D supplementation with hormonal therapy on cardiovascular disease. Menopause. 2019 Aug; 26(8):841-849.

2. Liu Q, Matthan NR, Manson JE, Howard BV, Tinker LF, Neuhouser ML, Van Horn LV, Rossouw JE, Allison MA, Martin LW, Li W, Snetselaar LG, Wang L, Lichtenstein AH, Eaton CB. Plasma Phospholipid Fatty Acids and Coronary Heart Disease Risk: A Matched Case-Control Study within the Women's Health Initiative Observational Study. Nutrients. 2019 Jul 21; 11(7).

3. Armstrong NM, Espeland MA, Chen JC, Masaki K, Wactawski-Wende J, Li W, Gass MLS, Stefanick ML, Manson JE, Deal JA, Rapp SR, Lin FR, Resnick SM. Associations of Hearing Loss and Menopausal Hormone Therapy with Change in Global Cognition and Incident Cognitive Impairment among Postmenopausal Women. J Gerontol A Biol Sci Med Sci. 2019 Jul 20.

4. Duran EK, Cook NR, Bobadilla M, Kim E, Manson JE, Buring JE, Ridker PM, Pradhan AD. Plasma Placental Growth Factor Concentrations Are Elevated Well in Advance of Type 2 Diabetes Mellitus Onset: Prospective Data From the WHS. J Am Heart Assoc. 2019 Aug 06; 8(15):e012790.

5. Kim ES, Fong K, Lee L, Spiro A, Schwartz J, Whitsel E, Horvath S, Wang C, Hou L, Baccarelli AA, Li Y, Stewart J, Manson JE, Grodstein F, DeMeo DL, Kubzansky LD. Optimism is not associated with two indicators of DNA methylation aging. Aging (Albany NY). 2019 Jul 18; 11(14):4970-4989.

6. Wang T, Heianza Y, Sun D, Zheng Y, Huang T, Ma W, Rimm EB, Manson JE, Hu FB, Willett WC, Qi L. Improving fruit and vegetable intake attenuates the genetic association with long-term weight gain. Am J Clin Nutr. 2019 Jul 13.

7. Sun Y, Liu B, Snetselaar LG, Wallace RB, Caan BJ, Rohan TE, Neuhouser ML, Shadyab AH, Chlebowski RT, Manson JE, Bao W. Association of Normal-Weight Central Obesity With All-Cause and Cause-Specific Mortality Among Postmenopausal Women. JAMA Netw Open. 2019 Jul 03; 2(7):e197337.

8. Baker LD, Rapp SR, Shumaker SA, Manson JE, Sesso HD, Gaussoin SA, Harris D, Caudle B, Pleasants D, Espeland MA. Design and baseline characteristics of the cocoa supplement and multivitamin outcomes study for the Mind: COSMOS-Mind. Contemp Clin Trials. 2019 Aug; 83:57-63.

9. Jiao J, Liu G, Shin HJ, Hu FB, Rimm EB, Rexrode KM, Manson JE, Zong G, Sun Q. Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies. BMJ. 2019 07 02; 366:l4009.

10. Freeborne N, Simmens SJ, Manson JE, Howard BV, Cené CW, Allison MA, Corbie-Smith G, Bell CL, Denburg NL, Martin LW. Perceived social support and the risk of cardiovascular disease and all-cause mortality in the Women's Health Initiative Observational Study. Menopause. 2019 Jul; 26(7):698-707.