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Karen H. Costenbader, MD, MPH

Rheumatologist, Brigham and Women's Hospital
 Associate Professor of Medicine, Harvard Medical School
Brigham and Women's Hospital
Department of Medicine
Rheumatology, Immunology
75 Francis Street
Boston, MA 02115

Research Location: Boston Lying-In

Research Narrative:

Our research is focused on epidemiology and outcomes of rheumatic diseases, in particular Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE).  Our group has developed innovative epidemiologic tools for testing hypotheses in populations, investigated the epidemiology of rheumatic diseases in large cohorts of female health professionals, studied predictors of outcome in RA and SLE and established a large SLE Registry.  

In recent work, our group has studied associations between cigarette smoking and RA and SLE, postmenopausal hormones and oral contraceptive use and risk of SLE, antioxidants and vitamin D intake and the risks of RA and SLE. We are investigating novel biomarkers and causal pathways in the development of RA. Our group also studies predictors of outcomes, including cardiovascular disease, lymphoma, nephritis and end-stage renal disease, among patients with SLE, and sociodemographic disparities in the incidence and outcomes of SLE in the U.S.. The BWH Lupus Registryincludes >1700 SLE patients from BWH and the BWH Lupus Biobank, housed at the Broad Institute, contains stored samples on many of this cohort. We are currently investigating biomarkers of SLE activity and disease risk, whether high dose vitamin D and/or fish oil intake are effective in the prevention of autoimmune disease, and access to care and outcomes among patients with SLE.
 
Education: Harvard School of Public Health, 2002, MPH
Harvard Medical School, 1995, MD
Cambridge University, 1991, MA
 
Honors/Awards: Mary Betty Stevens Young Investigator, Lupus Foundation of America, 2009
Henry Kunkel Young Investigator, American College of Rheumatology,2011
 
Lab Members: Elizabeth Arkema, MPH
Joseph Merola, MD
Linda Hiraki, MD, MPH
Candace Feldman, MD, MPH
Jose Gomez Puerta, MD, PhD
Sara Tedeschi, MD
 
Collaborators: Immaculata DeVivo, PhD, HSPH

JoAnn Manson, MD, DrPH, BWH

Daniel Solomon, MD, MPH, BWH

Elizabeth Karlson, MD, BWH

Elena Massarotti, MD, BWH

Wolfgang Winkelmayer, MD, ScD, Stanford University

Peter Schur, MD, BWH

Bonnie Bermas, MD, BWH

I-Min Lee, MD, MPH, BWH

George Tsokos, MD, PhD, BIDMC
 
Keywords (MeSH): Autoantibodies
Antirheumatic Agents
Peptides, Cyclic
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Lupus Erythematosus, Systemic
Arthritis, Rheumatoid
Lupus Nephritis
Rheumatic Diseases
Smoking
 

Publications (Pulled from Harvard Catalyst Profiles):

1. Feldman CH, Hiraki LT, Liu J, Fischer MA, Solomon DH, Alarcón GS, Winkelmayer WC, Costenbader KH. Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004. Arthritis Rheum. 2013 Mar; 65(3):753-63.

2. Hiraki LT, Munger KL, Costenbader KH, Karlson EW. Reply. Arthritis Care Res (Hoboken). 2013 Mar; 65(3):491-2.

3. Arkema EV, Hart JE, Bertrand KA, Laden F, Grodstein F, Rosner BA, Karlson EW, Costenbader KH. Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study. Ann Rheum Dis. 2013 Apr; 72(4):506-11.

4. Hiraki LT, Munger KL, Costenbader KH, Karlson EW. Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012 Dec; 64(12):1829-36.

5. Clowse ME, Chakravarty E, Costenbader KH, Chambers C, Michaud K. Reply. Arthritis Care Res (Hoboken). 2012 Nov; 64(11):1785-6.

6. Hiraki LT, Feldman CH, Liu J, Alarcón GS, Fischer MA, Winkelmayer WC, Costenbader KH. Prevalence, incidence, and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US Medicaid beneficiary population. Arthritis Rheum. 2012 Aug; 64(8):2669-76.

7. Hart JE, Källberg H, Laden F, Bellander T, Costenbader KH, Holmqvist M, Klareskog L, Alfredsson L, Karlson EW. Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case-control study. Ann Rheum Dis. 2012 Jul 24.

8. Miller FW, Alfredsson L, Costenbader KH, Kamen DL, Nelson LM, Norris JM, De Roos AJ. Epidemiology of environmental exposures and human autoimmune diseases: Findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J Autoimmun. 2012 Dec; 39(4):259-71.

9. Clowse ME, Chakravarty E, Costenbader KH, Chambers C, Michaud K. Effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012 May; 64(5):668-74.

10. Devlin A, Waikar SS, Solomon DH, Lu B, Shaykevich T, Alarcón GS, Winkelmayer WC, Costenbader KH. Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States. Arthritis Care Res (Hoboken). 2011 Dec; 63(12):1642-53.

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