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Karen H. Costenbader, MD, MPH
Rheumatologist, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Rheumatology, Immunology and Allergy
75 Francis Street
Boston, MA 02115

Research Location: Peter Bent Brigham

Phone: 617-732-5325
Fax: 617-732-5505
Email: kcostenbader@bwh.harvard.edu
Research Email: kcostenbader@bwh.harvard.edu

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Research Narrative:

 

Dr. Costenbader’s research investigates the epidemiology and pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). She has studied associations between cigarette smoking and RA and SLE, postmenopausal hormones and oral contraceptive use and risk of SLE, antioxidants and vitamin D intake and the risks of RA and SLE. With her research group, she also studies predictors of outcomes, including cardiovascular disease, lymphoma, nephritis and end-stage renal disease, among patients with SLE, and sociodemographic disparities in the incidence and outcomes of SLE in the U.S.. She is also currently investigating biomarkers of SLE activity and disease risk, whether high dose vitamin D or fish oil intake are effective in the prevention of autoimmune disease, and disparities in access to care and outcomes among patients with SLE. Dr. Costenbader is an active clinical research mentor for medical students, residents, graduate students in epidemiology, and rheumatology fellows and junior faculty.  She has trained over 30 doctoral and post-doctoral fellows. She is PI of the BWH Lupus Registry containing data on over 2300 patients with SLE, and has established the BWH Lupus Biobank, used for studies investigating biomarkers, molecular signatures and genetics.


Education:
Harvard School of Public Health, 2002, MPH
Harvard Medical School, 1995, MD
Cambridge University, 1991, MA

Honors/Awards:
Mary Betty Stevens Young Investigator, Lupus Foundation of America, 2009
Henry Kunkel Young Investigator, American College of Rheumatology,2011

Collaborators:
Candace Feldman, MD, ScD

May Choi, MD

Elizabeth Karlson, MD

JoAnn Manson, MD, DrPH

Elena Massarotti, MD

Brittany Weber, MD, PhD

Jeffrey Sparks, MD, MS

Medha Barbhaiya, MD, MPH


Publications (Pulled from Harvard Catalyst Profiles):

1. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 Aug 06.

2. Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman R, Smolen JS, Wofsy D, Boumpas DT, Kamen DL, Jayne D, Cervera R, Costedoat-Chalumeau N, Diamond B, Gladman DD, Hahn B, Hiepe F, Jacobsen S, Khanna D, Lerstrøm K, Massarotti E, McCune J, Ruiz-Irastorza G, Sanchez-Guerrero J, Schneider M, Urowitz M, Bertsias G, Hoyer BF, Leuchten N, Tani C, Tedeschi SK, Touma Z, Schmajuk G, Anic B, Assan F, Chan TM, Clarke AE, Crow MK, Czirják L, Doria A, Graninger W, Halda-Kiss B, Hasni S, Izmirly PM, Jung M, Kumánovics G, Mariette X, Padjen I, Pego-Reigosa JM, Romero-Diaz J, Rúa-Figueroa Fernández Í, Seror R, Stummvoll GH, Tanaka Y, Tektonidou MG, Vasconcelos C, Vital EM, Wallace DJ, Yavuz S, Meroni PL, Fritzler MJ, Naden R, Dörner T, Johnson SR. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019 Sep; 78(9):1151-1159.

3. Li D, Yoshida K, Feldman CH, Speyer C, Barbhaiya M, Guan H, Solomon DH, Everett BM, Costenbader KH. Initial disease severity, cardiovascular events and all-cause mortality among patients with systemic lupus erythematosus. Rheumatology (Oxford). 2019 Jul 18.

4. Feldman CH, Costenbader KH, Solomon DH, Subramanian SV, Kawachi I. Area-Level Predictors of Medication Nonadherence Among US Medicaid Beneficiaries With Lupus: A Multilevel Study. Arthritis Care Res (Hoboken). 2019 Jul; 71(7):903-913.

5. Liu X, Tedeschi SK, Barbhaiya M, Leatherwood CL, Speyer CB, Lu B, Costenbader KH, Karlson EW, Sparks JA. Impact and Timing of Smoking Cessation on Reducing Risk of Rheumatoid Arthritis Among Women in the Nurses' Health Studies. Arthritis Care Res (Hoboken). 2019 Jul; 71(7):914-924.

6. Malik VS, Guasch-Ferre M, Hu FB, Townsend MK, Zeleznik OA, Eliassen AH, Tworoger SS, Karlson EW, Costenbader KH, Ascherio A, Wilson KM, Mucci LA, Giovannucci EL, Fuchs CS, Bao Y. Identification of Plasma Lipid Metabolites Associated with Nut Consumption in US Men and Women. J Nutr. 2019 Jul 01; 149(7):1215-1221.

7. Leatherwood C, Speyer CB, Feldman CH, D'Silva K, Gómez-Puerta JA, Hoover PJ, Waikar SS, McMahon GM, Rennke HG, Costenbader KH. Clinical characteristics and renal prognosis associated with interstitial fibrosis and tubular atrophy (IFTA) and vascular injury in lupus nephritis biopsies. Semin Arthritis Rheum. 2019 Jun 11.

8. Chen SK, Barbhaiya M, Fischer MA, Guan H, Yoshida K, Feldman CH, Costenbader KH, Everett BM. Heart failure risk in systemic lupus erythematosus compared to diabetes mellitus and general medicaid patients. Semin Arthritis Rheum. 2019 Jun 11.

9. Tedeschi SK, Kim SC, Guan H, Grossman JM, Costenbader KH. Comparative Fracture Risks Among United States Medicaid Enrollees With and Those Without Systemic Lupus Erythematosus. Arthritis Rheumatol. 2019 Jul; 71(7):1141-1146.

10. Elman SA, Joyce C, Costenbader KH, Merola JF. Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study. Clin Exp Dermatol. 2019 May 23.