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Samuel Zachary Goldhaber, MD
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Cardiovascular
75 Francis Street
Boston, MA 02115


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Research Narrative:

Samuel Z. Goldhaber, MD, Professor of Medicine at Harvard Medical School, is Director of the BWH Venous Thromboembolism Research Group. He has been the Principal Investigator for multiple deep vein thrombosis (DVT) and pulmonary embolism (PE) treatment trials, including 5 multicenter PE thrombolysis trials. He is Chair of the Steering Committee of the NIH-sponsored multicenter ATTRACT Trial, which is studying the optimal method to manage massive DVT. He is especially interested in improving venous thromboembolism prophylaxis of at-risk hospitalized patients. In the March 10, 2005 New England Journal of Medicine, he published a 2,500 patient randomized clinical trial which described a new physician alert strategy to reduce symptomatic DVT and PE by 41%. He is currently conducting another 2,500 patient randomized clinical trial at 26 institutions across the United States to determine whether these positive results are reproducible outside of Brigham and Women’s Hospital.

Dr. Goldhaber is Principal Investigator of about a dozen ongoing randomized clinical trials and observational studies related to the prevention, treatment, and epidemiology of PE and DVT. As Founder and Director of the BWH Anticoagulation Service, which cares for more than 2,100 active patients, he is also conducting research on optimal warfarin dosing. He is Chair of the Steering Committee of the ADOPT Trial, which is studying the safety and efficacy of a new oral anticoagulant for prophylaxis of venous thromboembolism in acutely ill medical subjects during and following hospitalization. Dr. Goldhaber is also Principal Investigator of an observational trial exploring new ways to foster venous thromboembolism prophylaxis at the time of hospital discharge. He encourages Vascular Medicine Fellows to participate in these research projects.

Dr. Goldhaber is committed to promoting outreach to other health care professionals as well as to the lay public. He helped found and is President of the North American Thrombosis Forum, a nonprofit organization. He chairs the Steering Committee of the Venous Disease Coalition, another nonprofit initiative, run by the Vascular Disease Foundation.