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Kathryn Gray, MD, PhD
Associate Obstetrician, Brigham and Women's Hospital
Assistant Professor, Harvard Medical School

Brigham and Women's Hospital
Department of Obstetrics and Gynecology
Maternal-Fetal Medicine
75 Francis Street
Boston, MA 02115

Research Email: kgray6@bwh.harvard.edu

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Research Narrative:

As a physician-scientist with fellowship training in maternal-fetal medicine and clinical genetics, I am interested in using multi-omic approaches to understand the pathophysiology of adverse obstetric outcomes, in particular preeclampsia and postpartum hemorrhage. Under the direction of Dr. Richa Saxena (Center for Genomic Medicine, Massachusetts General Hospital), our lab has developed several key resources for advancing understanding of preeclampsia. We collected a well-phenotyped, multi-ethnic collection of maternal DNAs from women at the Partners Hospitals with a history of preeclampsia. A subset of this cohort was used as part of a multi-site genome-wide association study (GWAS) of maternal preeclampsia that identified a new hypertension-associated genetic locus for further investigation. We are currently establishing a preeclampsia consortium with both maternal and fetal samples for a larger genotyping and sequencing studies to identify additional genetic loci that predispose to preeclampsia.

In parallel to this work, we have utilized metabolomics in the BWH pregnancy cohort (LIFECODES) to define maternal plasma and urine metabolites longitudinally throughout pregnancy that are associated with later development of preeclampsia.  For postpartum hemorrhage, we are currently planning similar genomic and metabolomic analyses. Collectively, the goal of these investigations is to define causative pathways leading to preeclampsia and postpartum hemorrhage to improve predictive algorithms and catalyze the development of novel therapeutics.

During the COVID-19 pandemic as part of a Boston-wide effort, we established a SARS-CoV-2 infection and COVID-19 vaccination biorepository for pregnancy to understand consequences of viral infection and vaccination during pregnancy both for mothers and babies.


Education:
University of Michigan Medical School, 2007, MD PhD
University of Wisconsin-Madison, 1999, BS

Honors/Awards:
BIRCWH Scholar, 2017-2019
ACOG Mentor of the Year, 2017
Obstetrics and Gynecology Foundation Fellowship, 2017