Yonatan Hagai Grad
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Associate Physician, Brigham and Women's Hospital
Instructor in Medicine, Harvard Medical School
Brigham and Women's Hospital
Department of Medicine
Infectious Diseases
75 Francis Street
Boston, MA 02115
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| Research Narrative:
Yonatan Grad is an Assistant Professor in the Department of Immunology and Infectious Diseases at the Harvard TH Chan School of Public Health (HSPH) and an attending physician in the Division of Infectious Diseases at Brigham and Women’s Hospital (BWH) and Harvard Medical School. He earned his MD and PhD degrees at Harvard Medical School with his doctoral research in bioinformatics and genomics, and completed his internal medicine residency at Brigham and Women’s Hospital and clinical infectious diseases fellowship in the MGH/BWH combined program. Prior to joining the faculty at HSPH, he was a research fellow with Marc Lipsitch in the Center for Communicable Disease Dynamics at HSPH. Dr. Grad’s research investigates how pathogens evolve and spread using a combination of genomics, mathematical modeling, and epidemiological tools, and includes projects investigating the population genomics and emergence and spread of antibiotic resistance of Neisseria gonorrhoeae, the causative agent of gonorrhea.
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Publications (Pulled from Harvard Catalyst Profiles):
1. Peak CM, Childs LM, Grad YH, Buckee CO. Comparing nonpharmaceutical interventions for containing emerging epidemics. Proc Natl Acad Sci U S A. 2017 Apr 11; 114(15):4023-4028.
2. Eyre DW, De Silva D, Cole K, Peters J, Cole MJ, Grad YH, Demczuk W, Martin I, Mulvey MR, Crook DW, Walker AS, Peto TE, Paul J. WGS to predict antibiotic MICs for Neisseria gonorrhoeae. J Antimicrob Chemother. 2017 Mar 10.
3. Grad YH, Lipsitch M. Reply to Allan-Blitz and Klausner. J Infect Dis. 2017 Feb 01; 215(3):491-492.
4. Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP. Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks. Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5):1135-1140.
5. Johnson SR, Grad Y, Abrams AJ, Pettus K, Trees DL. Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance. Int J Antimicrob Agents. 2017 Feb; 49(2):252-254.
6. Grad YH, Harris SR, Kirkcaldy RD, Green AG, Marks DS, Bentley SD, Trees D, Lipsitch M. Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000-2013. J Infect Dis. 2016 Nov 15; 214(10):1579-1587.
7. Harrison OB, Clemence M, Dillard JP, Tang CM, Trees D, Grad YH, Maiden MC. Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance. J Infect. 2016 Dec; 73(6):578-587.
8. Unemo M, Golparian D, Sánchez-Busó L, Grad Y, Jacobsson S, Ohnishi M, Lahra MM, Limnios A, Sikora AE, Wi T, Harris SR. The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization. J Antimicrob Chemother. 2016 Nov; 71(11):3096-3108.
9. De Silva D, Peters J, Cole K, Cole MJ, Cresswell F, Dean G, Dave J, Thomas DR, Foster K, Waldram A, Wilson DJ, Didelot X, Grad YH, Crook DW, Peto TE, Walker AS, Paul J, Eyre DW. Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae: an observational study. Lancet Infect Dis. 2016 Nov; 16(11):1295-1303.
10. Grad YH, Fortune SM. Biodiversity and hypervirulence of Listeria monocytogenes. Nat Genet. 2016 Mar; 48(3):229-30.
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