Brigham and Women's Hospital: A Teaching Affiliate of Harvard Medical School
FIND A DOCTOR
REQUEST AN APPOINTMENT

TEXT SIZE: Increase Font Size / Decrease Font Size
PRINT
TRANSLATE:
What is this?
In:
  •  
  •  
  •  
  •  
  •  
  •  
  •  
Find A Researcher
  Previous  |  New Search  |  Return to Search Results  |  Next  

Yonatan Hagai Grad


  View Physician Profile

Associate Physician, Brigham and Women's Hospital
Instructor in Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Infectious Diseases
75 Francis Street
Boston, MA 02115



Research Narrative:

Yonatan Grad is an Assistant Professor in the Department of Immunology and Infectious Diseases at the Harvard TH Chan School of Public Health (HSPH) and an attending physician in the Division of Infectious Diseases at Brigham and Women’s Hospital (BWH) and Harvard Medical School. He earned his MD and PhD degrees at Harvard Medical School with his doctoral research in bioinformatics and genomics, and completed his internal medicine residency at Brigham and Women’s Hospital and clinical infectious diseases fellowship in the MGH/BWH combined program. Prior to joining the faculty at HSPH, he was a research fellow with Marc Lipsitch in the Center for Communicable Disease Dynamics at HSPH. Dr. Grad’s research investigates how pathogens evolve and spread using a combination of genomics, mathematical modeling, and epidemiological tools, and includes projects investigating the population genomics and emergence and spread of antibiotic resistance of Neisseria gonorrhoeae, the causative agent of gonorrhea.

 

Publications (Pulled from Harvard Catalyst Profiles):

1. Peak CM, Childs LM, Grad YH, Buckee CO. Comparing nonpharmaceutical interventions for containing emerging epidemics. Proc Natl Acad Sci U S A. 2017 Apr 11; 114(15):4023-4028.

2. Eyre DW, De Silva D, Cole K, Peters J, Cole MJ, Grad YH, Demczuk W, Martin I, Mulvey MR, Crook DW, Walker AS, Peto TE, Paul J. WGS to predict antibiotic MICs for Neisseria gonorrhoeae. J Antimicrob Chemother. 2017 Mar 10.

3. Grad YH, Lipsitch M. Reply to Allan-Blitz and Klausner. J Infect Dis. 2017 Feb 01; 215(3):491-492.

4. Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP. Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks. Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5):1135-1140.

5. Johnson SR, Grad Y, Abrams AJ, Pettus K, Trees DL. Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance. Int J Antimicrob Agents. 2017 Feb; 49(2):252-254.

6. Grad YH, Harris SR, Kirkcaldy RD, Green AG, Marks DS, Bentley SD, Trees D, Lipsitch M. Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000-2013. J Infect Dis. 2016 Nov 15; 214(10):1579-1587.

7. Harrison OB, Clemence M, Dillard JP, Tang CM, Trees D, Grad YH, Maiden MC. Genomic analyses of Neisseria gonorrhoeae reveal an association of the gonococcal genetic island with antimicrobial resistance. J Infect. 2016 Dec; 73(6):578-587.

8. Unemo M, Golparian D, Sánchez-Busó L, Grad Y, Jacobsson S, Ohnishi M, Lahra MM, Limnios A, Sikora AE, Wi T, Harris SR. The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization. J Antimicrob Chemother. 2016 Nov; 71(11):3096-3108.

9. De Silva D, Peters J, Cole K, Cole MJ, Cresswell F, Dean G, Dave J, Thomas DR, Foster K, Waldram A, Wilson DJ, Didelot X, Grad YH, Crook DW, Peto TE, Walker AS, Paul J, Eyre DW. Whole-genome sequencing to determine transmission of Neisseria gonorrhoeae: an observational study. Lancet Infect Dis. 2016 Nov; 16(11):1295-1303.

10. Grad YH, Fortune SM. Biodiversity and hypervirulence of Listeria monocytogenes. Nat Genet. 2016 Mar; 48(3):229-30.

show all
11. Grad YH, Goldstein E, Lipsitch M, White PJ. Improving Control of Antibiotic-Resistant Gonorrhea by Integrating Research Agendas Across Disciplines: Key Questions Arising From Mathematical Modeling. J Infect Dis. 2016 Mar 15; 213(6):883-90.

12. Pessia A, Grad Y, Cobey S, Puranen JS, Corander J. K-Pax2: Bayesian identification of cluster-defining amino acid positions in large sequence datasets. Microb Genom. 2015 Jul; 1(1):e000025.

13. Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch M. Origin and proliferation of multiple-drug resistance in bacterial pathogens. Microbiol Mol Biol Rev. 2015 Mar; 79(1):101-16.

14. Grad YH, Lipsitch M. Epidemiologic data and pathogen genome sequences: a powerful synergy for public health. Genome Biol. 2014 Nov 18; 15(11):538.

15. Watkins ER, Grad YH, Gupta S, Buckee CO. Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires. Sci Rep. 2014 Oct 09; 4:6554.

16. Johnson SR, Grad Y, Ganakammal SR, Burroughs M, Frace M, Lipsitch M, Weil R, Trees D. In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins. Antimicrob Agents Chemother. 2014 Nov; 58(11):6986-9.

17. Grad YH, Newman R, Zody M, Yang X, Murphy R, Qu J, Malboeuf CM, Levin JZ, Lipsitch M, DeVincenzo J. Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure. J Virol. 2014 Jul; 88(13):7286-93.

18. Grad YH, Kirkcaldy RD, Trees D, Dordel J, Harris SR, Goldstein E, Weinstock H, Parkhill J, Hanage WP, Bentley S, Lipsitch M. Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study. Lancet Infect Dis. 2014 Mar; 14(3):220-6.

19. Grad YH, Waldor MK. Deciphering the origins and tracking the evolution of cholera epidemics with whole-genome-based molecular epidemiology. MBio. 2013 Sep 10; 4(5):e00670-13.

20. Wei K, Vaidya A, Rohloff P, Sun YP, Grad Y. Interactive medical case. A patient with fevers and fatigue. N Engl J Med. 2013 Feb 14; 368(7):e9.

21. Croucher NJ, Harris SR, Grad YH, Hanage WP. Bacterial genomes in epidemiology--present and future. Philos Trans R Soc Lond B Biol Sci. 2013 Mar 19; 368(1614):20120202.

22. Grad YH, Godfrey P, Cerquiera GC, Mariani-Kurkdjian P, Gouali M, Bingen E, Shea TP, Haas BJ, Griggs A, Young S, Zeng Q, Lipsitch M, Waldor MK, Weill FX, Wortman JR, Hanage WP. Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. MBio. 2013 Jan 22; 4(1):e00452-12.

23. Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP. Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):E3629-30.

24. Grad YH, Miller JC, Lipsitch M. Cholera modeling: challenges to quantitative analysis and predicting the impact of interventions. Epidemiology. 2012 Jul; 23(4):523-30.

25. Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, Abouelleil A, Bochicchio J, Chauvin S, Desmet T, Gujja S, McCowan C, Montmayeur A, Steelman S, Frimodt-Møller J, Petersen AM, Struve C, Krogfelt KA, Bingen E, Weill FX, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3065-70.

26. Grad YH, Lipsitch M, Aiello AE. Secular trends in Helicobacter pylori seroprevalence in adults in the United States: evidence for sustained race/ethnic disparities. Am J Epidemiol. 2012 Jan 01; 175(1):54-9.

27. Grad YH, Seifter JL, Levy BD, Loscalzo J. Clinical problem-solving. Bitter pills. N Engl J Med. 2010 Nov 04; 363(19):1847-51.

28. Schaffer AC, Grad Y, Ross JJ. Interactive medical case. Bitter pills. N Engl J Med. 2010 Oct 14; 363(16):e26.

29. Grad YH, Roth FP, Halfon MS, Church GM. Prediction of similarly acting cis-regulatory modules by subsequence profiling and comparative genomics in Drosophila melanogaster and D.pseudoobscura. Bioinformatics. 2004 Nov 01; 20(16):2738-50.

30. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):360-5.

31. Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Mol Cell. 2003 May; 11(5):1253-63.

32. Halfon MS, Grad Y, Church GM, Michelson AM. Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Genome Res. 2002 Jul; 12(7):1019-28.


Send Feedback to the BWH Biomedical Research Institute.

Quick Links Find a Researcher Home
EDIT YOUR PROFILE

Related Links

Department
  • View all Research Faculty in the Department of Medicine
Division
  • View all Research Faculty: Infectious Diseases
BRI Research Center/Program Affiliation(s)
  • Genomics Center
  • Infectious and Immunologic Diseases Research Center
  • Bioinformatics Program


 

 

  • Follow Us On:
  • Facebook
  • Twitter
  • Health Hub
  • Pinterest
  • Googleplus
  • YouTube
  • RSS
  • Bookmark and Share
  • BWH Information
  • About BWH
  • Accessibility
  • BWH News
  • Careers
  • Contact Us
  • Giving to BWH
  • Patient Gateway
  • Quality and Safety
  • Resources A-L
  • Resources M-Z
  • Visiting BWH
  • Website Disclaimer
  • Website Privacy Policy
  • Web Site Map
  • Clinical Departments
  • Anesthesia
  • Cancer
  • Dermatology
  • Emergency Medicine
  • Medicine
  • Neurology
  • Neurosurgery
  • Newborn Medicine
  • Obstetrics and Gynecology
  • Orthopedic Surgery
  • Pathology
  • Physical Medicine and Rehabilitation
  • Psychiatry
  • Radiation Oncology
  • Radiology
  • Surgery
  • Women's Health
  • Centers of Excellence
  • Cancer Center
  • Heart and Vascular Center
  • Lung Center
  • Neurosciences Institute
  • Orthopedics and Arthritis Center
  • Women's Health
© Brigham and Women's Hospital 2015 | 75 Francis Street, Boston MA 02115 | 617-732-5500
Harvard Medical School logo Partners Healthcare logo