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Craig Palmer Hersh, MD
Assistant Professor, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Channing and Pulmonary
75 Francis Street
Boston, MA 02115

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Research Narrative:

Dr. Hersh is a faculty member in the Channing Laboratory and in the Pulmonary Division at Brigham and Women’s Hospital.  His research focuses on human studies of chronic obstructive pulmonary disease (COPD), using the tools of genetics, genomics and epidemiology to improve precision in diagnosis and treatment. He is the Principal Investigator of a pharmacogenomics ancillary study to the NHLBI-sponsored Long-term Oxygen Treatment Trial, which aims to use gene expression profiling and genotyping to identify predictors of response to oxygen therapy in COPD.  He is also the PI of a pharmacogenomics ancillary study to a clinical trial of inhaled corticosteroids in airway-predominant COPD, in order to identify genetic, genomic, and epigenetic factors associated with response to treatment, in terms of preventing COPD exacerbations.  These and other studies involve integration of various data types -- such clinical and imaging data, gene expression, and genetic variation -- to identify novel genes and pathways which affect COPD and related traits.  He serves as the co-director of the BWH clinical center in the nationwide COPDGene Study as well as a member of the genetics analysis core and the leader of the clinical subtypes working group in COPDGene.