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Andrew Siedlecki, MD
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Renal
75 Francis Street
Boston, MA 02115

Research Location: Harvard Institute of Medicine

Research Email: http://siedleckilab.bwh.harvard.edu/

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Research Narrative:

The kidney is one of the most vascular organs in the human body.  Our laboratory is seeking to understand the mechanisms of vascular injury in the kidney and offer solutions to accelerate the repair process.  Our latest work analyzes the regenerative capacity of cells found in the renal artery of people at risk for kidney disease.  Cultivation of such cells offers a potential therapy to patients during a future period of declining renal function


Education:
University of South Florida, 2003, MD

Honors/Awards:
ABIM Nephrology certified
AST/ASN Transplant Medicine certified
ABIM Internal Medicine certified

Publications (Pulled from Harvard Catalyst Profiles):

1. Siedlecki AM, Benson C, Frates M, Azzi J, Hoffman RJ, Milford E, Weins A, Chandraker A, Mc Donald N, White JP, Abdi R. First Report of Perfluorobutane Microsphere Enhanced Ultrasound in the Transplant Kidney. Transplantation. 2019 Jun 27.

2. Zhang H, Song M, Ruan L, Zhang F, Zhang A, Siedlecki AM, Wan M. Von Mises Strain as a Risk Marker for Vulnerability of Carotid Plaque: Preliminary Clinical Evaluation of Cerebral Infarction. Ultrasound Med Biol. 2019 05; 45(5):1221-1233.

3. Siedlecki AM, Isbel N, Vande Walle J, James Eggleston J, Cohen DJ. Eculizumab Use for Kidney Transplantation in Patients With a Diagnosis of Atypical Hemolytic Uremic Syndrome. Kidney Int Rep. 2019 Mar; 4(3):434-446.

4. Postalcioglu M, Kaze AD, Byun BC, Siedlecki A, Tullius SG, Milford EL, Paik JM, Abdi R. Association of Cold Ischemia Time With Acute Renal Transplant Rejection. Transplantation. 2018 07; 102(7):1188-1194.

5. Pang P, Abbott M, Abdi M, Fucci QA, Chauhan N, Mistri M, Proctor B, Chin M, Wang B, Yin W, Lu TS, Halim A, Lim K, Handy DE, Loscalzo J, Siedlecki AM. Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant. 2018 06 01; 33(6):923-934.

6. Chin MS, Steigner M, Yin W, Kwong RY, Siedlecki AM. Intraluminal Assessment of Coronary Arteries With Ferumoxytol-Enhanced Magnetic Resonance Angiography. JACC Cardiovasc Imaging. 2018 Mar; 11(3):505-508.

7. Reddy YN, Siedlecki AM, Francis JM. Breaking down the complement system: a review and update on novel therapies. Curr Opin Nephrol Hypertens. 2017 03; 26(2):123-128.

8. Pang P, Abbott M, Chang SL, Abdi M, Chauhan N, Mistri M, Ghofrani J, Fucci QA, Walker C, Leonardi C, Grady S, Halim A, Hoffman R, Lu T, Cao H, Tullius SG, Malek S, Kumar S, Steele G, Kibel A, Freedman BS, Waikar SS, Siedlecki AM. Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks. Kidney Int. 2017 01; 91(1):129-143.

9. Mukundan S, Steigner ML, Hsiao LL, Malek SK, Tullius SG, Chin MS, Siedlecki AM. Ferumoxytol-Enhanced Magnetic Resonance Imaging in Late-Stage CKD. Am J Kidney Dis. 2016 Jun; 67(6):984-8.

10. Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat Commun. 2015 Oct 23; 6:8715.