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Jacob Joseph, MD, MBBS
Associate Physician, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

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University of Kerala, 1991, MD
University of Kerala, 1988, MBBS

Lab Members:
Liangliang Zhang, PhD, Postdoctoral fellow

Publications (Pulled from Harvard Catalyst Profiles):

1. Joseph J. Orchestrating Metabolic Flexibility: PGC-1a and Clinical Heart Failure. Am J Med Sci. 2019 Apr; 357(4):273-274.

2. Zhang L, Joseph L, Joseph J. In Vivo and In Vitro Effects of Vasopressin V2 Receptor Antagonism on Myocardial Fibrosis in Rats. Am J Med Sci. 2019 Feb; 357(2):151-159.

3. Patel YR, Robbins JM, Kurgansky KE, Imran T, Orkaby AR, McLean RR, Ho YL, Cho K, Michael Gaziano J, Djousse L, Gagnon DR, Joseph J. Development and validation of a heart failure with preserved ejection fraction cohort using electronic medical records. BMC Cardiovasc Disord. 2018 06 28; 18(1):128.

4. Patel YR, Kurgansky KE, Imran TF, Orkaby AR, McLean RR, Ho YL, Cho K, Gaziano JM, Djousse L, Gagnon DR, Joseph J. Prognostic Significance of Baseline Serum Sodium in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2018 Jun 13; 7(12).

5. Vardeny O, Udell JA, Joseph J, Farkouh ME, Hernandez AF, McGeer AJ, Talbot HK, Bhatt DL, Cannon CP, Goodman SG, Anand I, DeMets DL, Temte J, Wittes J, Nichol K, Yancy CW, Gaziano JM, Cooper LS, Kim K, Solomon SD. High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial. Am Heart J. 2018 08; 202:97-103.

6. Tong S, Zhang L, Joseph J, Jiang X. Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway. Biochem Biophys Res Commun. 2018 03 11; 497(3):843-849.

7. Srivastava A, Do JM, Sales VL, Ly S, Joseph J. Impact of patient-centred home telehealth programme on outcomes in heart failure. J Telemed Telecare. 2018 Jan 01; 1357633X18775852.

8. Imran TF, Shin HJ, Mathenge N, Wang F, Kim B, Joseph J, Gaziano JM, Djoussé L. Meta-Analysis of the Usefulness of Plasma Galectin-3 to Predict the Risk of Mortality in Patients With Heart Failure and in the General Population. Am J Cardiol. 2017 Jan 01; 119(1):57-64.

9. Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart. Radiother Oncol. 2016 05; 119(2):259-64.

10. McMurray JJ, Krum H, Abraham WT, Dickstein K, Køber LV, Desai AS, Solomon SD, Greenlaw N, Ali MA, Chiang Y, Shao Q, Tarnesby G, Massie BM. Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure. N Engl J Med. 2016 Apr 21; 374(16):1521-32.