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John Weyl Winkelman, MD PhD
Associate Physician, Brigham and Women's Hospital
Professor of Psychiatry, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Sleep Medicine
75 Francis Street
Boston, MA 02115


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Research Narrative:

My research involves study of patients with restless legs syndrome (RLS), insomnia, mood disorders, and sleep-related eating disorders.  In RLS, we are doing 3 separate clinical trials for potential and approved medications for the disorder, investigating rotigitine for ESRD-related RLS as well as its ability to treat daytime symptoms in primary RLS, and a novel medication for primary RLS.  We are also beginning a study of cardiovascular control in RLS given our data that the disorder is associated with cardiovascular disease.  My RO1 investigates spectroscopically-derived GABA levels in patients with major depression with and without insomnia, those with primary insomnia, and those without either depression or insomnia.  Secondary outcomes involve objectively recorded sleep and functional and structural MRI.  Finally, other studies involve outcomes in patients with periodic limb movements of sleep and medication treatment of sleep-related eating disorder.


Education:
Harvard School of Medicine, 1987, MD
Harvard Graduate School of Arts and Sciences, 1983, PhD Psychobiology

Publications (Pulled from Harvard Catalyst Profiles):

1. During EH, Winkelman JW. Drug Treatment of Restless Legs Syndrome in Older Adults. Drugs Aging. 2019 Jul 26.

2. Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, Greenblatt AD, Jacobson AE, Rice KC, Casadó V, Newman AH, Winkelman JW, Michaelides M, Weintraub E, Volkow ND, Belcher AM, Ferré S. Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids. J Clin Invest. 2019 03 26; 129(7):2730-2744.

3. Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Biological and clinical insights from genetics of insomnia symptoms. Nat Genet. 2019 03; 51(3):387-393.

4. Chen TY, Winkelman JW, Mao WC, Yeh CB, Huang SY, Kao TW, Yang CCH, Kuo TBJ, Chen WL. Short Sleep Duration Is Associated With Increased Serum Homocysteine: Insights From a National Survey. J Clin Sleep Med. 2019 Jan 15; 15(1):139-148.

5. Salminen AV, Allen RP, Högl B, Inoue Y, Oertel W, Winkelman JW, Trenkwalder C, Sampaio C, Winkelmann J. Reply to: Safety of dopamine agonists for treating restless legs syndrome. Mov Disord. 2019 01; 34(1):150-151.

6. Salminen AV, Allen RP, Högl B, Inoue Y, Oertel W, Winkelman JW, Trenkwalder C, Sampaio C, Winkelmann J. Reply to: A note on rotigotine for restless legs syndrome after renal transplantation. Mov Disord. 2019 01; 34(1):152-153.

7. McCall CA, Winkelman JW. Respiratory-Related Leg Movements of Sleep Are Associated With Serotonergic Antidepressants But Not Bupropion. J Clin Sleep Med. 2018 Sep 15; 14(9):1569-1576.

8. Silber MH, Becker PM, Buchfuhrer MJ, Earley CJ, Ondo WG, Walters AS, Winkelman JW. In Reply-Additional Safety Considerations Before Prescribing Opioids to Manage Restless Legs Syndrome. Mayo Clin Proc. 2018 07; 93(7):955-956.

9. Winkelmann J, Allen RP, Högl B, Inoue Y, Oertel W, Salminen AV, Winkelman JW, Trenkwalder C, Sampaio C. Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice (Revised 2017)§. Mov Disord. 2018 07; 33(7):1077-1091.

10. Winkelman JW, Jaros MJ. Predictors of clinical response in a double-blind placebo controlled crossover trial of gabapentin enacarbil for restless legs syndrome. Sleep Med. 2018 Aug; 48:1-7.