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Lauren J. O'Donnell, PhD
Associate Research Associate, Brigham and Women's Hospital
Assistant Professor of Radiology, Harvard Medical School

Brigham and Women's Hospital
Department of Radiology
75 Francis Street
Boston, MA 02115

Research Location: 1249 Boylston Street

Research Email:

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Research Narrative:

I develop methods for studying the white matter tracts, or brain connections, using diffusion imaging. My work has focused on quantitative analysis and modeling of white matter tractography in groups of subjects, as well as modeling of the structure-function relationship in healthy subjects and tumor patients.

MIT, 2006, PhD

Publications (Pulled from Harvard Catalyst Profiles):

1. Zhang F, Ning L, O'Donnell LJ, Pasternak O. MK-curve - Characterizing the relation between mean kurtosis and alterations in the diffusion MRI signal. Neuroimage. 2019 08 01; 196:68-80.

2. Zhang F, Wu Y, Norton I, Rathi Y, Golby AJ, O'Donnell LJ. Test-retest reproducibility of white matter parcellation using diffusion MRI tractography fiber clustering. Hum Brain Mapp. 2019 Jul; 40(10):3041-3057.

3. Lyall AE, Savadjiev P, Del Re EC, Seitz J, O'Donnell LJ, Westin CF, Mesholam-Gately RI, Petryshen T, Wojcik JD, Nestor P, Niznikiewicz M, Goldstein J, Seidman LJ, McCarley RW, Shenton ME, Kubicki M. Utilizing Mutual Information Analysis to Explore the Relationship Between Gray and White Matter Structural Pathologies in Schizophrenia. Schizophr Bull. 2019 Mar 07; 45(2):386-395.

4. Dalamagkas K, Tsintou M, Rathi Y, O'Donnell LJ, Pasternak O, Gong X, Zhu A, Savadjiev P, Papadimitriou GM, Kubicki M, Yeterian EH, Makris N. Individual variations of the human corticospinal tract and its hand-related motor fibers using diffusion MRI tractography. Brain Imaging Behav. 2019 Jan 08.

5. Stojanovski S, Felsky D, Viviano JD, Shahab S, Bangali R, Burton CL, Devenyi GA, O'Donnell LJ, Szatmari P, Chakravarty MM, Ameis S, Schachar R, Voineskos AN, Wheeler AL. Polygenic Risk and Neural Substrates of Attention-Deficit/Hyperactivity Disorder Symptoms in Youths With a History of Mild Traumatic Brain Injury. Biol Psychiatry. 2019 Mar 01; 85(5):408-416.

6. Wu Y, Zhang F, Makris N, Ning Y, Norton I, She S, Peng H, Rathi Y, Feng Y, Wu H, O'Donnell LJ. Investigation into local white matter abnormality in emotional processing and sensorimotor areas using an automatically annotated fiber clustering in major depressive disorder. Neuroimage. 2018 11 01; 181:16-29.

7. Zhang F, Wu Y, Norton I, Rigolo L, Rathi Y, Makris N, O'Donnell LJ. An anatomically curated fiber clustering white matter atlas for consistent white matter tract parcellation across the lifespan. Neuroimage. 2018 10 01; 179:429-447.

8. Hong Y, O'Donnell LJ, Savadjiev P, Zhang F, Wassermann D, Pasternak O, Johnson H, Paulsen J, Vonsattel JP, Makris N, Westin CF, Rathi Y. Genetic load determines atrophy in hand cortico-striatal pathways in presymptomatic Huntington's disease. Hum Brain Mapp. 2018 10; 39(10):3871-3883.

9. Sydnor VJ, Rivas-Grajales AM, Lyall AE, Zhang F, Bouix S, Karmacharya S, Shenton ME, Westin CF, Makris N, Wassermann D, O'Donnell LJ, Kubicki M. A comparison of three fiber tract delineation methods and their impact on white matter analysis. Neuroimage. 2018 09; 178:318-331.

10. Gong S, Zhang F, Norton I, Essayed WI, Unadkat P, Rigolo L, Pasternak O, Rathi Y, Hou L, Golby AJ, O'Donnell LJ. Free water modeling of peritumoral edema using multi-fiber tractography: Application to tracking the arcuate fasciculus for neurosurgical planning. PLoS One. 2018; 13(5):e0197056.