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Mark Anthony Perrella, MD
Senior Research Associate, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Newborn Medicine
75 Francis Street
Boston, MA 02115


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Research Narrative:

Research Focus

The Perrella laboratory is interested in: 1) The regulation and biology of genes important for the modulation of inflammation and oxidative stress in systemic disease processes. A gene of particular interest is heme oxygenase-1, and its downstream product carbon monoxide, in mediating the pathobiology of sepsis and acute lung injury. 2) The regulation and biology of genes selectively expressed in muscle cells (smooth or striated). A recent focus has been the striated preferentially expressed gene (Speg) and its role in fetal heart development and function. 3) The commitment and differentiation of progenitor cells during the evolution of disease processes.

Research Goals

By investigating the molecular mechanisms regulating genes important in the pathogenesis of detrimental disease processes, the Perrella laboratory hopes to identify targets for more effective therapy. The ultimate goal is to develop novel strategies (including cell-based strategies) for the treatment of cardiopulmonary and vascular diseases for patients of all ages, from premature infants to adults.

Outcome/Application of Research

To translate our research into better care for patients of all ages, and to advance therapeutic strategies for disease processes with poor outcomes.


Education:
University of Nebraska Medical Center, 1986, MD
Chadron State College, 1982, BA