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Samuel Patz, PhD
Associate Research Associate, Brigham and Women's Hospital
Professor of Radiology, Harvard Medical School

Brigham and Women's Hospital
Department of Radiology
75 Francis Street
Boston, MA 02115

Research Location: Richardson Fuller


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Research Narrative:
I’m a physicist working to develop new MRI methods. Currently, I’m doing research in three areas:

 1. Hyperpolarized gas MRI to produce maps of pulmonary function including ventilation, gas exchange and perfusion. The subject inhales xenon gas that we have previously magnetized with a laser. We detect the signal both in the gas phase to provide maps of ventilation and in tissue and blood to measure gas exchange and perfusion.

2. Development of a lightweight, portable MR device for the ICU. We are developing this to assist clinicians in setting optimal ventilator pressures for patients who are on assisted mechanical ventilation. By measuring the regional response of lung density to changes in ventilator pressures, one can minimize lung collapse or over distension and thereby reduce the very high mortality rate from ventilator induced lung injury. We are also working on a version of this device to detect cerebral perfusion in the neurosurgical ICU.

3. Magnetic Resonance Elastography (MRE) of the brain. MRE is a technique that allows one to produce spatial maps of tissue elasticity and viscosity. We are developing this method for the brain and examining its ability to (i) detect and stage gliomas and (ii) diagnose and stage Alzheimer’s disease because of the anticipated change in mechanical properties with deposition of amyloid plaque and/or tau protein.


Education:
Brandeis University, 1979, PhD
Emory University, 1971, B.S.

Publications (Pulled from Harvard Catalyst Profiles):

1. Patz S, Fovargue D, Schregel K, Nazari N, Palotai M, Barbone PE, Fabry B, Hammers A, Holm S, Kozerke S, Nordsletten D, Sinkus R. Imaging localized neuronal activity at fast time scales through biomechanics. Sci Adv. 2019 Apr; 5(4):eaav3816.

2. Bezuidenhout AF, Khatami D, Heilman CB, Kasper EM, Patz S, Madan N, Zhao Y, Bhadelia RA. Relationship between Cough-Associated Changes in CSF Flow and Disease Severity in Chiari I Malformation: An Exploratory Study Using Real-Time MRI. AJNR Am J Neuroradiol. 2018 07; 39(7):1267-1272.

3. Schregel K, Nazari N, Nowicki MO, Palotai M, Lawler SE, Sinkus R, Barbone PE, Patz S. Characterization of glioblastoma in an orthotopic mouse model with magnetic resonance elastography. NMR Biomed. 2018 10; 31(10):e3840.

4. Bhadelia RA, Patz S, Heilman C, Khatami D, Kasper E, Zhao Y, Madan N. Cough-Associated Changes in CSF Flow in Chiari I Malformation Evaluated by Real-Time MRI. AJNR Am J Neuroradiol. 2016 May; 37(5):825-30.

5. Gill RR, Patz S, Muradyan I, Seethamraju RT. Novel MR Imaging Applications for Pleural evaluation. Magn Reson Imaging Clin N Am. 2015 May; 23(2):179-95.

6. Dabaghyan M, Muradyan I, Hrovat A, Butler J, Frederick E, Zhou F, Kyriazis A, Hardin C, Patz S, Hrovat M. A portable single-sided magnet system for remote NMR measurements of pulmonary function. NMR Biomed. 2014 Dec; 27(12):1479-89.

7. Nikolaou P, Coffey AM, Walkup LL, Gust BM, Whiting N, Newton H, Muradyan I, Dabaghyan M, Ranta K, Moroz GD, Rosen MS, Patz S, Barlow MJ, Chekmenev EY, Goodson BM. XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use. Magn Reson Imaging. 2014 Jun; 32(5):541-50.

8. Nikolaou P, Coffey AM, Walkup LL, Gust BM, Whiting N, Newton H, Barcus S, Muradyan I, Dabaghyan M, Moroz GD, Rosen MS, Patz S, Barlow MJ, Chekmenev EY, Goodson BM. Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14150-5.

9. Bhadelia RA, Madan N, Zhao Y, Wagshul ME, Heilman C, Butler JP, Patz S. Physiology-based MR imaging assessment of CSF flow at the foramen magnum with a valsalva maneuver. AJNR Am J Neuroradiol. 2013 Sep; 34(9):1857-62.

10. Richdale K, Sinnott LT, Bullimore MA, Wassenaar PA, Schmalbrock P, Kao CY, Patz S, Mutti DO, Glasser A, Zadnik K. Quantification of age-related and per diopter accommodative changes of the lens and ciliary muscle in the emmetropic human eye. Invest Ophthalmol Vis Sci. 2013 Feb 07; 54(2):1095-105.