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Alexey V. Fedulov, MD, Ph.D.
Associate Immunologist, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

My laboratory studies epigenetic regulation and aims to design a molecular tool for epigenetic editing. Any cell in an organism includes all genes of that organism's genome. The difference in structure and function of cells results from epigenetic silencing of 'unnecessary genes' by DNA methylation. No effective approach currently exists to gene-specifically demethylate the gene promoters, and little is known about DNA demethylation mechanisms. The research aims to develop fusion molecules of putative DNA demethylases with sequence-specific DNA binding domains and use these tools to enable or enhance the function of silenced intrinsic genes in cells. The method will be useful to treat diseases with aberrant DNA hypermethylation, to confer unusual properties to cells including transdifferentiation; it would allow upregulation of defensive factors for immunotherapeutic purposes, it may assist in proliferation of non-dividing specialized cells like cardiomyocytes or neurons for regenerative purposes, and broadly will be useful anywhere enhancement of function of intrinsic genes is required.

St. Petersburg State Pavlov Medical University, 2003, Ph.D.
St. Petersburg State Pavlov Medical University, 2001, MD