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Paul B. Shyn, MD


  View Physician Profile

Associate Radiologist, Brigham and Women's Hospital
Associate Professor of Radiology, Harvard Medical School

Brigham and Women's Hospital
Department of Radiology
75 Francis Street
Boston, MA 02115



Research Narrative:

I am an Abdominal Radiologist and am involved in both diagnostic imaging and interventional radiology procedures. My research interests focus primarily on image-guided interventions such as biopsy, drainage and tumor ablation procedures. The use of PET/CT to guide interventions and the use of PET/CT to improve the intraprocedural assessment of tumor ablation procedures is a particular interest. Most of my studies have been retrospective, clinical research projects, but I have a prospective study with industry funding that will begin this fall. Another ongoing project is a collaborative effort with initial seed funding from the BWH/Innovation Hub to develop a needle track cautery device to minimize bleeding risk and tumor seeding along the needle biopsy track.

 
Education: Ochsner Clinic, Diagnostic Radiolog
University of California, San Francisco, Abdominal Imaging
University of Texas Medical Branch, MD
 

Publications (Pulled from Harvard Catalyst Profiles):

1. Young AS, Shyn PB, Johnson OW, Sainani NI, Nawfel RD, Silverman SG. Bending percutaneous drainage catheters to facilitate CT-guided insertion using curved trocar technique. Abdom Radiol (NY). 2017 Mar 30.

2. Shyn PB, O'Neill AC, Wiggins WF, Sainani NI, Tatli S, Tuncali K, Levesque VM, Silverman SG. Hepatobiliary phase MRI: impact on planning image-guided liver tumor ablations. Abdom Radiol (NY). 2017 Mar 27.

3. Bhagavatula SK, Chick JF, Chauhan NR, Shyn PB. Artificial ascites and pneumoperitoneum to facilitate thermal ablation of liver tumors: a pictorial essay. Abdom Radiol (NY). 2017 Feb; 42(2):620-630.

4. Bhagavatula SK, Shyn PB. Image-Guided Renal Interventions. Radiol Clin North Am. 2017 Mar; 55(2):359-371.

5. Shyn PB, Tremblay-Paquet S, Palmer K, Tatli S, Tuncali K, Olubiyi OI, Hata N, Silverman SG. Breath-hold PET/CT-guided tumour ablation under general anaesthesia: accuracy of tumour image registration and projected ablation zone overlap. Clin Radiol. 2017 Mar; 72(3):223-229.

6. Guenette JP, Tuncali K, Himes N, Shyn PB, Lee TC. Percutaneous Image-Guided Cryoablation of Head and Neck Tumors for Local Control, Preservation of Functional Status, and Pain Relief. AJR Am J Roentgenol. 2017 Feb; 208(2):453-458.

7. Burch EA, Shyn PB, Chick JF, Chauhan NR. Auditing an Online Self-reported Interventional Radiology Adverse Event Database for Compliance and Accuracy. J Am Coll Radiol. 2017 Apr; 14(4):494-498.

8. Burch EA, Shyn PB. Developing an Interventional Radiology Online Quality Assurance Database. J Am Coll Radiol. 2017 Mar; 14(3):383-385.

9. Shyn PB, Bird JR, Koch RM, Tatli S, Levesque VM, Catalano PJ, Silverman SG. Hepatic Microwave Ablation Zone Size: Correlation with Total Energy, Net Energy, and Manufacturer-Provided Chart Predictions. J Vasc Interv Radiol. 2016 Sep; 27(9):1389-96.

10. Kelil T, Shyn PB, Wu LE, Levesque VM, Kacher D, Khorasani R, Silverman SG. Wall suction-assisted image-guided therapeutic paracentesis: a safe and less expensive alternative to evacuated bottles. Abdom Radiol (NY). 2016 Jul; 41(7):1333-7.

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11. Sainani NI, Silverman SG, Tuna IS, Aghayev A, Shyn PB, Tuncali K, Kadiyala V, Tatli S. Incidence and clinical sequelae of portal and hepatic venous thrombosis following percutaneous cryoablation of liver tumors. Abdom Radiol (NY). 2016 May; 41(5):970-7.

12. Fintelmann FJ, Tuncali K, Puchner S, Gervais DA, Thabet A, Shyn PB, Arellano RS, Tatli S, Mueller PR, Silverman SG, Uppot RN. Catecholamine Surge during Image-Guided Ablation of Adrenal Gland Metastases: Predictors, Consequences, and Recommendations for Management. J Vasc Interv Radiol. 2016 Mar; 27(3):395-402.

13. Levesque VM, Shyn PB, Tuncali K, Tatli S, Nawfel RD, Olubiyi O, Silverman SG. Radiation dose during CT-guided percutaneous cryoablation of renal tumors: Effect of a dose reduction protocol. Eur J Radiol. 2015 Nov; 84(11):2218-21.

14. Sarma A, Shyn PB, Vivian MA, Ng JM, Tuncali K, Lorch JH, Zaheer SN, Gordon MS, Silverman SG. Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome. Cardiovasc Intervent Radiol. 2015 Oct; 38(5):1335-8.

15. Lemay A, Shyn PB, Foley R, Beutler SS, Silverman SG, Urman RD. A procedural sedation quality improvement audit form tool for interventional radiology. J Med Pract Manage. 2015 Mar-Apr; 30(6 Spec No):44-7.

16. Hong TS, Bosch WR, Krishnan S, Kim TK, Mamon HJ, Shyn P, Ben-Josef E, Seong J, Haddock MG, Cheng JC, Feng MU, Stephans KL, Roberge D, Crane C, Dawson LA. Interobserver variability in target definition for hepatocellular carcinoma with and without portal vein thrombus: radiation therapy oncology group consensus guidelines. Int J Radiat Oncol Biol Phys. 2014 Jul 15; 89(4):804-13.

17. Colak E, Tatli S, Shyn PB, Tuncali K, Silverman SG. CT-guided percutaneous cryoablation of central lung tumors. Diagn Interv Radiol. 2014 Jul-Aug; 20(4):316-22.

18. Fairchild AH, Tatli S, Dunne RM, Shyn PB, Tuncali K, Silverman SG. Percutaneous cryoablation of hepatic tumors adjacent to the gallbladder: assessment of safety and effectiveness. J Vasc Interv Radiol. 2014 Sep; 25(9):1449-55.

19. Shyn PB, Mauri G, Alencar RO, Tatli S, Shah SH, Morrison PR, Catalano PJ, Silverman SG. Percutaneous imaging-guided cryoablation of liver tumors: predicting local progression on 24-hour MRI. AJR Am J Roentgenol. 2014 Aug; 203(2):W181-91.

20. Dunne RM, Shyn PB, Sung JC, Tatli S, Morrison PR, Catalano PJ, Silverman SG. Percutaneous treatment of hepatocellular carcinoma in patients with cirrhosis: a comparison of the safety of cryoablation and radiofrequency ablation. Eur J Radiol. 2014 Apr; 83(4):632-8.

21. Shyn PB, Tatli S, Sahni VA, Sadow CA, Forgione K, Mauri G, Morrison PR, Catalano PJ, Silverman SG. PET/CT-guided percutaneous liver mass biopsies and ablations: targeting accuracy of a single 20 s breath-hold PET acquisition. Clin Radiol. 2014 Apr; 69(4):410-5.

22. Sainani NI, Tatli S, Anthony SG, Shyn PB, Tuncali K, Silverman SG. Successful percutaneous radiologic management of renal cell carcinoma tumor seeding caused by percutaneous biopsy performed before ablation. J Vasc Interv Radiol. 2013 Sep; 24(9):1404-8.

23. Shyn PB. Interventional positron emission tomography/computed tomography: state-of-the-art. Tech Vasc Interv Radiol. 2013 Sep; 16(3):182-90.

24. Sainani NI, Arellano RS, Shyn PB, Gervais DA, Mueller PR, Silverman SG. The challenging image-guided abdominal mass biopsy: established and emerging techniques 'if you can see it, you can biopsy it'. Abdom Imaging. 2013 Aug; 38(4):672-96.

25. Wasser EJ, Shyn PB, Riveros-Angel M, Sadow CA, Steele GS, Silverman SG. Renal cell carcinoma containing abundant non-calcified fat. Abdom Imaging. 2013 Jun; 38(3):598-602.

26. Javery O, Shyn P, Mortele K. FDG PET or PET/CT in patients with pancreatic cancer: when does it add to diagnostic CT or MRI? Clin Imaging. 2013 Mar-Apr; 37(2):295-301.

27. Shinagare AB, Shyn PB, Sadow CA, Wasser EJ, Catalano P. Incidence, appropriateness, and consequences of recommendations for additional imaging tests in oncological PET/CT reports. Clin Radiol. 2013 Feb; 68(2):155-61.

28. Liszewski MC, Sahni VA, Shyn PB, Friedman S, Hornick JL, Erturk SM, Mortele KJ. Multidetector-row computed tomography enterographic assessment of the ileal-anal pouch: descriptive radiologic analysis with endoscopic and pathologic correlation. J Comput Assist Tomogr. 2012 Jul-Aug; 36(4):394-9.

29. Shyn PB. 18F-FDG positron emission tomography: potential utility in the assessment of Crohn's disease. Abdom Imaging. 2012 Jun; 37(3):377-86.

30. Fernandes DD, Shyn PB, Silverman SG. Gallbladder needle decompression during radiofrequency ablation of an adjacent liver tumour. Can Assoc Radiol J. 2012 Aug; 63(3 Suppl):S37-40.

31. Shyn PB, Oliva MR, Shah SH, Tatli S, Catalano PJ, Silverman SG. MRI contrast enhancement of malignant liver tumours following successful cryoablation. Eur Radiol. 2012 Feb; 22(2):398-403.

32. Shyn PB, Tatli S, Sainani NI, Morrison PR, Habbab F, Catalano P, Silverman SG. Minimizing image misregistration during PET/CT-guided percutaneous interventions with monitored breath-hold PET and CT acquisitions. J Vasc Interv Radiol. 2011 Sep; 22(9):1287-92.

33. Park BK, Morrison PR, Tatli S, Govindarajulu U, Tuncali K, Judy P, Shyn PB, Silverman SG. Estimated effective dose of CT-guided percutaneous cryoablation of liver tumors. Eur J Radiol. 2012 Aug; 81(8):1702-6.

34. Tatli S, Gerbaudo VH, Feeley CM, Shyn PB, Tuncali K, Silverman SG. PET/CT-guided percutaneous biopsy of abdominal masses: initial experience. J Vasc Interv Radiol. 2011 Apr; 22(4):507-14.

35. Sainani NI, Shyn PB, Tatli S, Morrison PR, Tuncali K, Silverman SG. PET/CT-guided radiofrequency and cryoablation: is tumor fluorine-18 fluorodeoxyglucose activity dissipated by thermal ablation? J Vasc Interv Radiol. 2011 Mar; 22(3):354-60.

36. Sahni VA, Shyn PB. Predicting the need for surgery in obstructive Crohn's disease: how hot is PET/CT? Inflamm Bowel Dis. 2010 Dec; 16(12):2182-3.

37. Shyn PB, Mortele KJ, Britz-Cunningham SH, Friedman S, Odze RD, Burakoff R, Goldberg JE, Erturk M, Silverman SG. Low-dose 18F-FDG PET/CT enterography: improving on CT enterography assessment of patients with Crohn disease. J Nucl Med. 2010 Dec; 51(12):1841-8.

38. Elhawary H, Oguro S, Tuncali K, Morrison PR, Tatli S, Shyn PB, Silverman SG, Hata N. Multimodality non-rigid image registration for planning, targeting and monitoring during CT-guided percutaneous liver tumor cryoablation. Acad Radiol. 2010 Nov; 17(11):1334-44.

39. Tatli S, Gerbaudo VH, Mamede M, Tuncali K, Shyn PB, Silverman SG. Abdominal masses sampled at PET/CT-guided percutaneous biopsy: initial experience with registration of prior PET/CT images. Radiology. 2010 Jul; 256(1):305-11.

40. Shyn PB, Madan R, Wu C, Erturk SM, Silverman SG. PET/CT pattern analysis for surgical staple line recurrence in patients with colorectal cancer. AJR Am J Roentgenol. 2010 Feb; 194(2):414-21.

41. Oei TN, Shyn PB, Govindarajulu U, Flint R. Diagnostic medical radiation dose in patients after laparoscopic bariatric surgery. Obes Surg. 2010 May; 20(5):569-73.

42. Schenker MP, Martin R, Shyn PB, Baum RA. Interventional radiology and anesthesia. Anesthesiol Clin. 2009 Mar; 27(1):87-94.

43. Elhawary H, Oguro S, Tuncali K, Morrison PR, Shyn PB, Tatli S, Silverman SG, Hat N. Intra-operative multimodal non-rigid registration of the liver for navigated tumor ablation. Med Image Comput Comput Assist Interv. 2009; 12(Pt 1):837-44.

44. Shyn PB. Diagnostic medical radiation in IBD. Inflamm Bowel Dis. 2008 Oct; 14(10):1455-6.

45. Shyn PB. Protocol considerations for thoracic positron emission tomography-computed tomography. Semin Ultrasound CT MR. 2008 Aug; 29(4):242-50.

46. Thoeni RF, Mueller-Lisse UG, Chan R, Do NK, Shyn PB. Detection of small, functional islet cell tumors in the pancreas: selection of MR imaging sequences for optimal sensitivity. Radiology. 2000 Feb; 214(2):483-90.

47. Shyn PB, Goldberg HI. Abdominal CT following liver transplantation. Gastrointest Radiol. 1992; 17(3):231-6.

48. Shyn PB, Bell KA. Transient cortical blindness following cerebral angiography. J La State Med Soc. 1989 Nov; 141(11):35-7.

49. Bluth EI, Shyn PB, Sullivan MA, Merritt CR. Doppler color flow imaging of carotid artery dissection. J Ultrasound Med. 1989 Mar; 8(3):149-53.

50. Shyn PB, Campbell GA, Guinto FC, Crofford MJ. Primary intracranial ependymoblastoma presenting as spinal cord compression due to metastasis. Childs Nerv Syst. 1986; 2(6):323-5.


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