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Thomas Frederick McElrath, MD, PhD
Associate Obstetrician & Gynecologist, Brigham and Women's Hospital
Associate Professor of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School

Brigham and Women's Hospital
Department of Obstetrics and Gynecology
75 Francis Street
Boston, MA 02115

Research Location: Mary Horrigan Connors Center


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Research Narrative:

I am PI on the LIFECODES birth cohort run by the Maternal-Fetal Medicine Division of the BWH. This is one of the largest prospectively collected biobanks for human pregnancy in North America. My personal research areas are divided into to primary interests:

1)  The development of biomarkers to predict adverse pregnancy outcome. Specifically, my work involved  the use of exosome associated proteins sampled at the beginning of gestation to predict the risk of spontaneous preterm birth in the third trimester.

2) The association between environmental exposures and pregnancy complication. Phthalate and other plasticizers are associated with a variety of adverse reproductive outcomes. Using the longitudinal samples and data available in the LIFECODES cohort, our group has been able to refine the effect of these exposures on the risk of preeclampsia, spontaneous preterm birth and intrauterine growth restriction.  


Education:
Harvard Medical School, 1996, M.D.
University of Pennsylvania, 1994, Ph.D.
MD
PhD

Honors/Awards:
Fulbright Scholar
Excellence in Teaching - Association of Professors of Gynecology and Obstetrics (APGO)
Outstanding Teacher of Obstetrics - Brigham & Women's Department of OB/GYN
Partners Service Award - Brigham & Women's Hospital
Paper of the Year Award 2014 - National Institute of Environmental Health Sciences
Boston Magazine Top Physician 2017 – present

Lab Members:
David Cantonwine, Ph.D.

Collaborators:
John Meeker ,PhD, University of Michigan, Phthalates research

Kelly Ferguson ,PhD, NIEHS, Phthalates research

Scott Weiss, MD, Channing Lab, Brigham & Womens, Birth outcomes research

Kevin Rosenblatt MD, PhD, University of Texas Health Science Center at Houston, Biomarker research

Zhen Zhang, PhD, Johns Hopkins, Biomarker research


Resources:
LIFECODES Longitudinal Birth Cohort

Other Professional Activities:
Scientific Advisory Board, NxPrenatal
Board Examiner, American Board of Obstetrics & Gynecology

Publications (Pulled from Harvard Catalyst Profiles):

1. Darling AM, Werler MM, Cantonwine DE, Fawzi WW, McElrath TF. Timing and Amount of Gestational Weight Gain in Association with Adverse Birth Outcomes. Epidemiology. 2019 Sep; 30(5):695-705.

2. Margulis AV, Hernandez-Diaz S, McElrath T, Rothman KJ, Plana E, Almqvist C, D'Onofrio BM, Oberg AS. Relation of in-utero exposure to antiepileptic drugs to pregnancy duration and size at birth. PLoS One. 2019; 14(8):e0214180.

3. MacDonald SC, Cohen JM, Panchaud A, McElrath TF, Huybrechts KF, Hernández-Díaz S. Identifying pregnancies in insurance claims data: Methods and application to retinoid teratogenic surveillance. Pharmacoepidemiol Drug Saf. 2019 Jul 22.

4. Bromage S, Enkhmaa D, Baatar T, Garmaa G, Bradwin G, Yondonsambuu B, Sengee T, Jamts E, Suldsuren N, McElrath TF, Cantonwine DE, Hoover RN, Troisi R, Ganmaa D. Comparison of seasonal serum 25-hydroxyvitamin D concentrations among pregnant women in Mongolia and Boston. J Steroid Biochem Mol Biol. 2019 Jul 16; 193:105427.

5. Bommarito PA, Kim SS, Meeker JD, Fry RC, Cantonwine DE, McElrath TF, Ferguson KK. Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach. Environ Health. 2019 Jul 12; 18(1):63.

6. Ferguson KK, Lan Z, Yu Y, Mukherjee B, McElrath TF, Meeker JD. Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates. Environ Int. 2019 Jul 06; 131:104903.

7. Sen S, Herlihy M, Hacker M, Mcelrath T, Cherkerzian S, Oken E, Meydani S. BMI-based Prenatal Vitamins to Ameliorate Oxidative Stress in Obese Pregnant Women: A Randomized Controlled Trial (P11-135-19). Curr Dev Nutr. 2019 Jun; 3(Suppl 1).

8. Ferguson KK, Rosario Z, McElrath TF, Vélez Vega C, Cordero JF, Alshawabkeh A, Meeker JD. Demographic risk factors for adverse birth outcomes in Puerto Rico in the PROTECT cohort. PLoS One. 2019; 14(6):e0217770.

9. Darling AM, Werler MM, Cantonwine DE, Fawzi WW, McElrath TF. Accuracy of a mixed effects model interpolation technique for the estimation of pregnancy weight values. J Epidemiol Community Health. 2019 Aug; 73(8):786-792.

10. De Tina A, Juang J, McElrath TF, Baty JD, Palanisamy A. Oxytocin and Oxytocinase in the Obese and Nonobese Parturients during Induction and Augmentation of Labor. AJP Rep. 2019 Apr; 9(2):e177-e184.