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Edward E. Whang, MD
Associate Surgeon, Brigham and Women's Hospital
Associate Professor of Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Surgery
75 Francis Street
Boston, MA 02115

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Research Narrative:

My laboratory research focuses on pancreatic adenocarcinoma.  Among the deadliest of all human malignancies, pancreatic cancer is associated with the propensity for metastasis and resistance to therapeutic interventions.  Our goal has been to develop strategies for inhibiting metastasis and chemoresistance in patients with pancreatic cancer.  This work has led to the identification of novel effectors (eg, CEACAM6) that promote both metastasis and chemoresistance in pancreatic cancer cells.  We have shown that targeted therapy directed at CEACAM6 increases anticancer efficacy of the chemotherapeutic agent gemcitabine, inhibits metastasis, and prolongs survival in a preclinical model of pancreatic cancer.  Further, using samples derived from patients having undergone surgical resection of pancreatic cancers at BWH, we have shown that CEACAM6 is abundantly expressed in > 90% of human pancreatic adenocarcinomas and that patients with CEACAM6-expressing cancers have significantly shorter postoperative survival durations than those with CEACAM6-negative cancers.  These findings subsequently have been confirmed by others and have been shown to be of relevance to a broad range of cancers (not just pancreatic cancer).  Additional work has focused on characterizing mechanisms of action of CEACAM6 and on identification of other mediators of metastasis and chemoresistance in pancreatic cancer.

Clinical research projects relate to surgical therapy for benign and malignant conditions of the gastrointestinal tract.  This work has been based on database reviews, decision analysis, and one RCT. 


Publications (Pulled from Harvard Catalyst Profiles):

1. Stolarski AE, Kim NE, O'Neal P, Sanchez V, Whang E, Kristo G. Implementation of an Intraoperative Instructional Timeout Just Prior to Stapler Use Improves Proficiency of Surgical Stapler Usage by Surgery Residents. J Surg Educ. 2019 Jun 22.

2. Mahvi DA, Pak LM, Bose SK, Urman RD, Gold JS, Whang EE. Fast-Track Pancreaticoduodenectomy: Factors Associated with Early Discharge. World J Surg. 2019 May; 43(5):1332-1341.

3. Mahvi DA, Pak LM, Fields AC, Urman RD, Gold JS, Whang EE. Prediction of Discharge Destination Following Major Hepatectomy. HPB (Oxford). 2019 Apr 04.

4. Kim NE, Moseley JM, O'Neal P, Whang E, Itani KMF, Kristo G. Retired Surgeons as Mentors for Surgical Training Graduates Entering Practice: An Underutilized Resource. Ann Surg. 2019 Mar 19.

5. Gustafsson UO, Scott MJ, Hubner M, Nygren J, Demartines N, Francis N, Rockall TA, Young-Fadok TM, Hill AG, Soop M, de Boer HD, Urman RD, Chang GJ, Fichera A, Kessler H, Grass F, Whang EE, Fawcett WJ, Carli F, Lobo DN, Rollins KE, Balfour A, Baldini G, Riedel B, Ljungqvist O. Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018. World J Surg. 2019 Mar; 43(3):659-695.

6. Nelson B, Na Eun K, Sullivan B, O'Neal P, Sanchez V, Whang E, Kristo G. Playing the Surgical Technologist Role by Surgery Residents Improves Their Technical and Nontechnical Skills. J Surg Res. 2019 Jun; 238:57-63.

7. Mahvi DA, Pak LM, Urman RD, Gold JS, Whang EE. Discharge destination following pancreaticoduodenectomy: A NSQIP analysis of predictive factors and post-discharge outcomes. Am J Surg. 2019 Aug; 218(2):342-348.

8. Saadat LV, Fields AC, Lyu H, Urman RD, Whang EE, Goldberg J, Bleday R, Melnitchouk N. National Surgical Quality Improvement Program analysis of unplanned reoperation in patients undergoing low anterior resection or abdominoperineal resection for rectal cancer. Surgery. 2019 Mar; 165(3):602-607.

9. Brovman EY, Foley CA, Shen AH, Whang EE, Urman RD. Intraoperative Ventilation Patterns in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery. J Laparoendosc Adv Surg Tech A. 2018 Dec; 28(12):1463-1470.

10. Yost MT, Jolissaint JS, Fields AC, Whang EE. Mechanical and Oral Antibiotic Bowel Preparation in the Era of Minimally Invasive Surgery and Enhanced Recovery. J Laparoendosc Adv Surg Tech A. 2018 May; 28(5):491-495.