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Edward E. Whang, MD
Associate Surgeon, Brigham and Women's Hospital
Associate Professor of Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Surgery
75 Francis Street
Boston, MA 02115


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Research Narrative:

My laboratory research focuses on pancreatic adenocarcinoma.  Among the deadliest of all human malignancies, pancreatic cancer is associated with the propensity for metastasis and resistance to therapeutic interventions.  Our goal has been to develop strategies for inhibiting metastasis and chemoresistance in patients with pancreatic cancer.  This work has led to the identification of novel effectors (eg, CEACAM6) that promote both metastasis and chemoresistance in pancreatic cancer cells.  We have shown that targeted therapy directed at CEACAM6 increases anticancer efficacy of the chemotherapeutic agent gemcitabine, inhibits metastasis, and prolongs survival in a preclinical model of pancreatic cancer.  Further, using samples derived from patients having undergone surgical resection of pancreatic cancers at BWH, we have shown that CEACAM6 is abundantly expressed in > 90% of human pancreatic adenocarcinomas and that patients with CEACAM6-expressing cancers have significantly shorter postoperative survival durations than those with CEACAM6-negative cancers.  These findings subsequently have been confirmed by others and have been shown to be of relevance to a broad range of cancers (not just pancreatic cancer).  Additional work has focused on characterizing mechanisms of action of CEACAM6 and on identification of other mediators of metastasis and chemoresistance in pancreatic cancer.

Clinical research projects relate to surgical therapy for benign and malignant conditions of the gastrointestinal tract.  This work has been based on database reviews, decision analysis, and one RCT. 


Education:
MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Gustafsson UO, Scott MJ, Hubner M, Nygren J, Demartines N, Francis N, Rockall TA, Young-Fadok TM, Hill AG, Soop M, de Boer HD, Urman RD, Chang GJ, Fichera A, Kessler H, Grass F, Whang EE, Fawcett WJ, Carli F, Lobo DN, Rollins KE, Balfour A, Baldini G, Riedel B, Ljungqvist O. Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018. World J Surg. 2019 Mar; 43(3):659-695.

2. Nelson B, Na Eun K, Sullivan B, O'Neal P, Sanchez V, Whang E, Kristo G. Playing the Surgical Technologist Role by Surgery Residents Improves Their Technical and Nontechnical Skills. J Surg Res. 2019 Feb 06; 238:57-63.

3. Mahvi DA, Pak LM, Bose SK, Urman RD, Gold JS, Whang EE. Fast-Track Pancreaticoduodenectomy: Factors Associated with Early Discharge. World J Surg. 2019 Jan 24.

4. Saadat LV, Fields AC, Lyu H, Urman RD, Whang EE, Goldberg J, Bleday R, Melnitchouk N. National Surgical Quality Improvement Program analysis of unplanned reoperation in patients undergoing low anterior resection or abdominoperineal resection for rectal cancer. Surgery. 2019 Mar; 165(3):602-607.

5. Brovman EY, Foley CA, Shen AH, Whang EE, Urman RD. Intraoperative Ventilation Patterns in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery. J Laparoendosc Adv Surg Tech A. 2018 Jun 05.

6. Yost MT, Jolissaint JS, Fields AC, Whang EE. Mechanical and Oral Antibiotic Bowel Preparation in the Era of Minimally Invasive Surgery and Enhanced Recovery. J Laparoendosc Adv Surg Tech A. 2018 May; 28(5):491-495.

7. Lyu HG, Sharma G, Brovman EY, Ejiofor J, Urman RD, Gold JS, Whang EE. Unplanned reoperation after hepatectomy: an analysis of risk factors and outcomes. HPB (Oxford). 2018 07; 20(7):591-596.

8. Whang EE, Stopfkuchen-Evans MF. Enhanced Recovery After Surgery: A New Standard for Perioperative Care. J Laparoendosc Adv Surg Tech A. 2017 09; 27(9):859.

9. Senturk JC, Kristo G, Gold J, Bleday R, Whang E. The Development of Enhanced Recovery After Surgery Across Surgical Specialties. J Laparoendosc Adv Surg Tech A. 2017 Sep; 27(9):863-870.

10. Helander EM, Webb MP, Bias M, Whang EE, Kaye AD, Urman RD. Use of Regional Anesthesia Techniques: Analysis of Institutional Enhanced Recovery After Surgery Protocols for Colorectal Surgery. J Laparoendosc Adv Surg Tech A. 2017 Sep; 27(9):898-902.