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William G. Richards, PhD
Associate Research Associate, Brigham and Women's Hospital
Assistant Professor of Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Surgery
75 Francis Street
Boston, MA 02115


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Research Narrative:
As the first dedicated non-clinician scientist hired into the Division of Thoracic Surgery, my professional development reflects having straddled between the Division’s basic and clinical science programs as they have evolved. Bench research has concerned neuronal control of esophageal peristalsis and molecular prognosis, classification and staging of lung cancer and mesothelioma. Clinical research has included retrospective case series analysis, in-house prospective clinical trials, and implementation of a patient data registry for the International Mesothelioma Program that prompted a comprehensive evaluation of prognostic and staging criteria for this rare disease. I have also participated in national multi-institutional clinical trials research through the Cancer and Leukemia Group B (presently Alliance for Clinical Trials in Oncology). In the context of genomic research and personalized medicine, biospecimen science has evolved as a distinct discipline, and I have been an active participant in the development of this new field. Early recognition of the need to stabilize, quality control, preserve and annotate specimens inspired an interest in developing and codifying protocols in these areas. Since 1990, I have operated a biorepository for thoracic surgical specimens that was expanded in 2000 as an institutional core service that remains in operation today. I currently co-chair the Best Practices and Operations subcommittee of the NCI’s National Clinical Trial Network Biospecimen Banks.

Education:
PhD

Publications (Pulled from Harvard Catalyst Profiles):

1. Chirieac LR, Hung YP, Foo WC, Hofer MD, VanderLaan PA, Richards WG, Sugarbaker DJ, Bueno R. Diagnostic value of biopsy sampling in predicting histology in patients with diffuse malignant pleural mesothelioma. Cancer. 2019 Aug 07.

2. Follo C, Cheng Y, Richards WG, Bueno R, Broaddus VC. Autophagy facilitates the release of immunogenic signals following chemotherapy in 3D models of mesothelioma. Mol Carcinog. 2019 Jun 19.

3. Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. Immunity. 2019 May 21; 50(5):1317-1334.e10.

4. Díaz-Tocados JM, Rodríguez-Ortiz ME, Almadén Y, Pineda C, Martínez-Moreno JM, Herencia C, Vergara N, Pendón-Ruiz de Mier MV, Santamaría R, Rodelo-Haad C, Casado-Díaz A, Lorenzo V, Carvalho C, Frazão JM, Felsenfeld AJ, Richards WG, Aguilera-Tejero E, Rodríguez M, López I, Muñoz-Castañeda JR. Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration. Kidney Int. 2019 May; 95(5):1064-1078.

5. Follo C, Barbone D, Richards WG, Bueno R, Courtney Broaddus V. Autophagy in 3D In Vitro and Ex Vivo Cancer Models. Methods Mol Biol. 2019; 1880:491-510.

6. Yu H, Chen Z, Ballman KV, Watson MA, Govindan R, Lanc I, Beer DG, Bueno R, Chirieac LR, Chui MH, Chen G, Franklin WA, Gandara DR, Genova C, Brovsky KA, Joshi MM, Merrick DT, Richards WG, Rivard CJ, Harpole DH, Tsao MS, van Bokhoven A, Shepherd FA, Hirsch FR. Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma. J Thorac Oncol. 2019 Jan; 14(1):25-36.

7. Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560.

8. Shi SY, Lu YW, Richardson J, Min X, Weiszmann J, Richards WG, Wang Z, Zhang Z, Zhang J, Li Y. A systematic dissection of sequence elements determining ß-Klotho and FGF interaction and signaling. Sci Rep. 2018 Jul 23; 8(1):11045.

9. Verkaik M, Juni RP, van Loon EPM, van Poelgeest EM, Kwekkeboom RFJ, Gam Z, Richards WG, Ter Wee PM, Hoenderop JG, Eringa EC, Vervloet MG. FGF23 impairs peripheral microvascular function in renal failure. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1414-H1424.

10. Bell R, Lipham J, Louie B, Williams V, Luketich J, Hill M, Richards W, Dunst C, Lister D, McDowell-Jacobs L, Reardon P, Woods K, Gould J, Buckley FP, Kothari S, Khaitan L, Smith CD, Park A, Smith C, Jacobsen G, Abbas G, Katz P. Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial. Gastrointest Endosc. 2019 01; 89(1):14-22.e1.