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Thomas Mark Michel, MD, PhD
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Cardiovascular
75 Francis Street
Boston, MA 02115

Research Location: Thorn Research Building

Research Email: thomas_michel@hms.harvard.edu

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Research Narrative:

Dr. Thomas Michel's laboratory studies signal transduction pathways in the cardiovascular system, with a particular focus on nitric oxide synthases and intracellular oxidant pathways. Nitric oxide (NO) has been studied for many years as the active compound that is formed from important cardiovascular drugs such as nitroglycerin,  More recently it was discovered that a family of nitric oxide synthases catalyze the formation of NO in diverse tissues. His lab has studied the endothelial isoform of nitric oxide synthase (eNOS), a key signaling enzyme that is activated by a variety of cell surface receptors and is involved in the control of vascular smooth muscle relaxation and platelet aggregation. Endothelium-dependent vascular smooth muscle relaxation is altered or impaired in models of atherosclerosis, hypertension, diabetes and hypercholesterolemia. Insights into these disease states may be gained by a thorough understanding of the structural and regulatory features of the endothelial cell nitric oxide synthase signaling system.

Dr. Michel's laboratory applies a broad range of experimental approaches to characterize intracellular signaling pathways in vascular endothelial cells and cardiac myocytes, from analyses of subcellular targeting to explorations of novel protein modifications.  His lab also studies the interplay among protein kinases, intracellular oxidants, eNOS and other signaling proteins using biochemical, biophysical, and cellular imaging approaches.  In addition, his laboratory has developed novel chemogenetic approaches and exploited informative biosensors to study the interplay of intracellular oxidants and NO-modulated pathways in the control of cell signaling  in normal cardiovascular tissues and in pathophysiological states caused by oxidative stress.

 


Education:
Duke University, 1984, MD
Duke University, 1983, PhD (Biochemistry)
Harvard Colege, 1977, A.B.

Courses Taught:
Spring semester, annually, HMS, BCMP234, Cellular metabolism and human disease

annually in July, BWH/HMS Catalyst, Models of Disease Boot Camp, 3 week boot camp for physician-scientists completing their clinical subspecialty training and returning to the lab for a basic/translational research fellowship