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Tanya M Laidlaw, MD
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Rheumatology, Immunology
75 Francis Street
Boston, MA 02115

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Research Narrative:
Our research is focused on understanding Aspirin Exacerbated Respiratory Disease (AERD), also known as Aspirin Sensitive Asthma or Samter’s Triad. We are investigating the causative mechanisms of AERD/Samter’s Triad, as well as exploring new treatments for the disease and working to understand how patients can become desensitized to aspirin. In recent work, we have studied the inflammatory role of the platelet in the overproduction of cysteinyl leukotrienes by patients with AERD/Samter’s Triad, and hope to determine whether platelets contribute to the aspirin-induced reactions.
Our group at the Brigham and Women’s Hospital’s Center for Allergic Disease Research follows over 150 patients with AERD/Samter’s Triad and have several ongoing research studies that are currently recruiting and enrolling patients.

University of Massachusetts Medical School, 2003, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Huang GX, Palumbo ML, Singer JI, Cahill KN, Laidlaw TM. Sinus surgery improves lower respiratory reactivity during aspirin desensitization for AERD. J Allergy Clin Immunol Pract. 2019 Mar 12.

2. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 Jan 21.

3. Laidlaw TM. Clinical updates in aspirin-exacerbated respiratory disease. Allergy Asthma Proc. 2019 Jan 01; 40(1):4-6.

4. Kiladejo A, Palumbo M, Laidlaw TM. Accidental ingestion of aspirin and nonsteroidal anti-inflammatory drugs is common in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2018 Nov 24.

5. DeGregorio GA, Singer J, Cahill KN, Laidlaw T. A 1-Day, 90-Minute Aspirin Challenge and Desensitization Protocol in Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2018 Nov 02.

6. Cahill KN, Murphy K, Singer J, Israel E, Boyce JA, Laidlaw TM. Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 Feb; 143(2):799-803.e2.

7. Laidlaw TM, Prussin C, Panettieri RA, Lee S, Ferguson BJ, Adappa ND, Lane AP, Palumbo ML, Sullivan M, Archibald D, Dworetzky SI, Hebrank GT, Bozik ME. Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size. Laryngoscope. 2019 Feb; 129(2):E61-E66.

8. Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Nizankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzynska A. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper. Allergy. 2019 Jan; 74(1):28-39.

9. Eid RC, Palumbo ML, Laidlaw TM, Buchheit KM, Cahill KN. A retrospective analysis of esophageal eosinophilia in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2018 Sep 25.

10. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654.