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Tanya M Laidlaw, MD
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Rheumatology, Immunology
75 Francis Street
Boston, MA 02115




Research Narrative:
Our research is focused on understanding Aspirin Exacerbated Respiratory Disease (AERD), also known as Aspirin Sensitive Asthma or Samter’s Triad. We are investigating the causative mechanisms of AERD/Samter’s Triad, as well as exploring new treatments for the disease and working to understand how patients can become desensitized to aspirin. In recent work, we have studied the inflammatory role of the platelet in the overproduction of cysteinyl leukotrienes by patients with AERD/Samter’s Triad, and hope to determine whether platelets contribute to the aspirin-induced reactions.
Our group at the Brigham and Women’s Hospital’s Center for Allergic Disease Research follows over 150 patients with AERD/Samter’s Triad and have several ongoing research studies that are currently recruiting and enrolling patients.

Education:
University of Massachusetts Medical School, 2003, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Hagan JB, Laidlaw TM, Divekar R, O'Brien EK, Kita H, Volcheck GW, Hagan CR, Lal D, Teaford HG, Erwin PJ, Zhang N, Rank MA. Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis. J Allergy Clin Immunol Pract. 2017 Feb 12.

2. Cahill KN, Laidlaw TM. Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am. 2016 Nov; 36(4):681-691.

3. Cahill KN, Johns CB, Cui J, Wickner P, Bates DW, Laidlaw TM, Beeler PE. Automated identification of an aspirin-exacerbated respiratory disease cohort. J Allergy Clin Immunol. 2017 Mar; 139(3):819-825.e6.

4. Shah NH, Schneider TR, DeFaria Yeh D, Cahill KN, Laidlaw TM. Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2016 Nov - Dec; 4(6):1215-1219.

5. Buchheit KM, Laidlaw TM. Update on the Management of Aspirin-Exacerbated Respiratory Disease. Allergy Asthma Immunol Res. 2016 Jul; 8(4):298-304.

6. Tuttle KL, Schneider TR, Henrickson SE, Morris D, Abonia JP, Spergel JM, Laidlaw TM. Aspirin-exacerbated respiratory disease: not always "adult-onset". J Allergy Clin Immunol Pract. 2016 Jul-Aug; 4(4):756-8.

7. Yamaguchi M, Zacharia J, Laidlaw TM, Balestrieri B. PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation. J Leukoc Biol. 2016 Jul; 100(1):131-41.

8. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504.

9. Laidlaw TM, Boyce JA. Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. N Engl J Med. 2016 Feb 04; 374(5):484-8.

10. Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):34-40.