Piero Anversa, MD - Department of Anesthesiology, Perioperative and Pain Medicine

Piero Anversa, MD

Scientist, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Anesthesiology, Perioperative and Pain Medicine
75 Francis Street
Boston, MA 02115

Education:	MD

Keywords (MeSH):	Myocardium Regeneration Myocytes, Cardiac Cardiomegaly Heart

Publications (Pulled from Harvard Catalyst Profiles): 1. Schoenfeld M, Frishman WH, Leri A, Kajstura J, Anversa P. The existence of myocardial repair: mechanistic insights and enhancements. Cardiol Rev. 2013 May-Jun; 21(3):111-20. 2. Anversa P, Kajstura J, Rota M, Leri A. Regenerating new heart with stem cells. J Clin Invest. 2013 Jan 2; 123(1):62-70. 3. Leri A, Anversa P. Stem cells and myocardial regeneration: cooperation wins over competition. Circulation. 2013 Jan 15; 127(2):165-8. 4. Welt FG, Gallegos R, Connell J, Kajstura J, D'Amario D, Kwong RY, Coelho-Filho O, Shah R, Mitchell R, Leri A, Foley L, Anversa P, Pfeffer MA. Effect of cardiac stem cells on left-ventricular remodeling in a canine model of chronic myocardial infarction. Circ Heart Fail. 2013 Jan 1; 6(1):99-106. 5. Chugh AR, Beache GM, Loughran JH, Mewton N, Elmore JB, Kajstura J, Pappas P, Tatooles A, Stoddard MF, Lima JA, Slaughter MS, Anversa P, Bolli R. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation. 2012 Sep 11; 126(11 Suppl 1):S54-64. 6. Kajstura J, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y, Ferreira-Martins J, Signore S, Sanada F, Matsuda A, Kostyla J, Caballero MV, Fiorini C, D'Alessandro DA, Michler RE, del Monte F, Hosoda T, Perrella MA, Leri A, Buchholz BA, Loscalzo J, Anversa P. Cardiomyogenesis in the aging and failing human heart. Circulation. 2012 Oct 9; 126(15):1869-81. 7. Burt RK, Chen YH, Verda L, Lucena C, Navale S, Johnson J, Han X, Lomasney J, Baker JM, Ngai KL, Kino A, Carr J, Kajstura J, Anversa P. Mitotically inactivated embryonic stem cells can be used as an in vivo feeder layer to nurse damaged myocardium after acute myocardial infarction: a preclinical study. Circ Res. 2012 Oct 26; 111(10):1286-96. 8. Kajstura J, Bai Y, Cappetta D, Kim J, Arranto C, Sanada F, D'Amario D, Matsuda A, Bardelli S, Ferreira-Martins J, Hosoda T, Leri A, Rota M, Loscalzo J, Anversa P. Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium. Circ Res. 2012 Sep 14; 111(7):894-906. 9. Anversa P, Leri A, Kajstura J. Biased DNA segregation during stem cell division. Circ Res. 2012 May 25; 110(11):1403-7. 10. Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J. Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012 Aug; 42(8):900-13. show all 11. Ferreira-Martins J, Ogórek B, Cappetta D, Matsuda A, Signore S, D'Amario D, Kostyla J, Steadman E, Ide-Iwata N, Sanada F, Iaffaldano G, Ottolenghi S, Hosoda T, Leri A, Kajstura J, Anversa P, Rota M. Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells. Circ Res. 2012 Mar 2; 110(5):701-15. 12. Zhang Y, Yuan M, Bradley KM, Dong F, Anversa P, Ren J. Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function. Hypertension. 2012 Mar; 59(3):680-93. 13. Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, Beache GM, Wagner SG, Leri A, Hosoda T, Sanada F, Elmore JB, Goichberg P, Cappetta D, Solankhi NK, Fahsah I, Rokosh DG, Slaughter MS, Kajstura J, Anversa P. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011 Nov 26; 378(9806):1847-57. 14. Frati C, Savi M, Graiani G, Lagrasta C, Cavalli S, Prezioso L, Rossetti P, Mangiaracina C, Ferraro F, Madeddu D, Musso E, Stilli D, Rossini A, Falco A, Angelis AD, Rossi F, Urbanek K, Leri A, Kajstura J, Anversa P, Quaini E, Quaini F. Resident cardiac stem cells. Curr Pharm Des. 2011 Oct; 17(30):3252-7. 15. Leri A, Kajstura J, Anversa P. Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ Res. 2011 Sep 30; 109(8):941-61. 16. Anversa P, Kajstura J, Leri A, Loscalzo J. Tissue-specific adult stem cells in the human lung. Nat Med. 2011 Sep; 17(9):1038-9. 17. Hosoda T, Rota M, Kajstura J, Leri A, Anversa P. Role of stem cells in cardiovascular biology. J Thromb Haemost. 2011 Jul; 9 Suppl 1:151-61. 18. Leri A, Hosoda T, Kajstura J, Anversa P, Rota M. Identification of a coronary stem cell in the human heart. J Mol Med (Berl). 2011 Oct; 89(10):947-59. 19. Cesselli D, Beltrami AP, D'Aurizio F, Marcon P, Bergamin N, Toffoletto B, Pandolfi M, Puppato E, Marino L, Signore S, Livi U, Verardo R, Piazza S, Marchionni L, Fiorini C, Schneider C, Hosoda T, Rota M, Kajstura J, Anversa P, Beltrami CA, Leri A. Effects of age and heart failure on human cardiac stem cell function. Am J Pathol. 2011 Jul; 179(1):349-66. 20. Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogórek B, Rondon-Clavo C, Ferreira-Martins J, Matsuda A, Arranto C, Goichberg P, Giordano G, Haley KJ, Bardelli S, Rayatzadeh H, Liu X, Quaini F, Liao R, Leri A, Perrella MA, Loscalzo J, Anversa P. Evidence for human lung stem cells. N Engl J Med. 2011 May 12; 364(19):1795-806. 21. D'Amario D, Cabral-Da-Silva MC, Zheng H, Fiorini C, Goichberg P, Steadman E, Ferreira-Martins J, Sanada F, Piccoli M, Cappetta D, D'Alessandro DA, Michler RE, Hosoda T, Anastasia L, Rota M, Leri A, Anversa P, Kajstura J. Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration. Circ Res. 2011 Jun 10; 108(12):1467-81. 22. Goichberg P, Bai Y, D'Amario D, Ferreira-Martins J, Fiorini C, Zheng H, Signore S, del Monte F, Ottolenghi S, D'Alessandro DA, Michler RE, Hosoda T, Anversa P, Kajstura J, Rota M, Leri A. The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction. Circ Res. 2011 Apr 29; 108(9):1071-83. 23. Hosoda T, Zheng H, Cabral-da-Silva M, Sanada F, Ide-Iwata N, Ogórek B, Ferreira-Martins J, Arranto C, D'Amario D, del Monte F, Urbanek K, D'Alessandro DA, Michler RE, Anversa P, Rota M, Kajstura J, Leri A. Human cardiac stem cell differentiation is regulated by a mircrine mechanism. Circulation. 2011 Mar 29; 123(12):1287-96. 24. D'Amario D, Fiorini C, Campbell PM, Goichberg P, Sanada F, Zheng H, Hosoda T, Rota M, Connell JM, Gallegos RP, Welt FG, Givertz MM, Mitchell RN, Leri A, Kajstura J, Pfeffer MA, Anversa P. Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ Res. 2011 Apr 1; 108(7):857-61. 25. Leri A, Kajstura J, Anversa P. Mechanisms of myocardial regeneration. Trends Cardiovasc Med. 2011 Feb; 21(2):52-8. 26. Kajstura J, Gurusamy N, Ogórek B, Goichberg P, Clavo-Rondon C, Hosoda T, D'Amario D, Bardelli S, Beltrami AP, Cesselli D, Bussani R, del Monte F, Quaini F, Rota M, Beltrami CA, Buchholz BA, Leri A, Anversa P. Myocyte turnover in the aging human heart. Circ Res. 2010 Nov 26; 107(11):1374-86. 27. Zhang B, Turdi S, Li Q, Lopez FL, Eason AR, Anversa P, Ren J. Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: Roles of Akt, mTOR, GSK3beta, and PTEN. Free Radic Biol Med. 2010 Oct 15; 49(7):1238-53. 28. Urbanek K, Cabral-da-Silva MC, Ide-Iwata N, Maestroni S, Delucchi F, Zheng H, Ferreira-Martins J, Ogórek B, D'Amario D, Bauer M, Zerbini G, Rota M, Hosoda T, Liao R, Anversa P, Kajstura J, Leri A. Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart. Circ Res. 2010 Aug 6; 107(3):429-41. 29. Kajstura J, Urbanek K, Perl S, Hosoda T, Zheng H, Ogórek B, Ferreira-Martins J, Goichberg P, Rondon-Clavo C, Sanada F, D'Amario D, Rota M, Del Monte F, Orlic D, Tisdale J, Leri A, Anversa P. Cardiomyogenesis in the adult human heart. Circ Res. 2010 Jul 23; 107(2):305-15. 30. Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, del Monte F. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 2010 Mar 16; 121(10):1216-26. 31. Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, Dai S, Li C, Chen N, Peng Y, Dawn B, Hunt G, Leri A, Kajstura J, Tiwari S, Shirk G, Anversa P, Bolli R. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation. 2010 Jan 19; 121(2):293-305. 32. De Angelis A, Piegari E, Cappetta D, Marino L, Filippelli A, Berrino L, Ferreira-Martins J, Zheng H, Hosoda T, Rota M, Urbanek K, Kajstura J, Leri A, Rossi F, Anversa P. Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation. 2010 Jan 19; 121(2):276-92. 33. Hosoda T, Kajstura J, Leri A, Anversa P. Mechanisms of myocardial regeneration. Circ J. 2010 Jan; 74(1):13-7. 34. D'Alessandro DA, Kajstura J, Hosoda T, Gatti A, Bello R, Mosna F, Bardelli S, Zheng H, D'Amario D, Padin-Iruegas ME, Carvalho AB, Rota M, Zembala MO, Stern D, Rimoldi O, Urbanek K, Michler RE, Leri A, Anversa P. Progenitor cells from the explanted heart generate immunocompatible myocardium within the transplanted donor heart. Circ Res. 2009 Nov 20; 105(11):1128-40. 35. Hosoda T, D'Amario D, Cabral-Da-Silva MC, Zheng H, Padin-Iruegas ME, Ogorek B, Ferreira-Martins J, Yasuzawa-Amano S, Amano K, Ide-Iwata N, Cheng W, Rota M, Urbanek K, Kajstura J, Anversa P, Leri A. Clonality of mouse and human cardiomyogenesis in vivo. Proc Natl Acad Sci U S A. 2009 Oct 6; 106(40):17169-74. 36. Ferreira-Martins J, Rondon-Clavo C, Tugal D, Korn JA, Rizzi R, Padin-Iruegas ME, Ottolenghi S, De Angelis A, Urbanek K, Ide-Iwata N, D'Amario D, Hosoda T, Leri A, Kajstura J, Anversa P, Rota M. Spontaneous calcium oscillations regulate human cardiac progenitor cell growth. Circ Res. 2009 Oct 9; 105(8):764-74. 37. Bearzi C, Leri A, Lo Monaco F, Rota M, Gonzalez A, Hosoda T, Pepe M, Qanud K, Ojaimi C, Bardelli S, D'Amario D, D'Alessandro DA, Michler RE, Dimmeler S, Zeiher AM, Urbanek K, Hintze TH, Kajstura J, Anversa P. Identification of a coronary vascular progenitor cell in the human heart. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15885-90. 38. Padin-Iruegas ME, Misao Y, Davis ME, Segers VF, Esposito G, Tokunou T, Urbanek K, Hosoda T, Rota M, Anversa P, Leri A, Lee RT, Kajstura J. Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation. 2009 Sep 8; 120(10):876-87. 39. Cesselli D, Beltrami AP, Rigo S, Bergamin N, D'Aurizio F, Verardo R, Piazza S, Klaric E, Fanin R, Toffoletto B, Marzinotto S, Mariuzzi L, Finato N, Pandolfi M, Leri A, Schneider C, Beltrami CA, Anversa P. Multipotent progenitor cells are present in human peripheral blood. Circ Res. 2009 May 22; 104(10):1225-34. 40. Srinivas G, Anversa P, Frishman WH. Cytokines and myocardial regeneration: a novel treatment option for acute myocardial infarction. Cardiol Rev. 2009 Jan-Feb; 17(1):1-9. 41. Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA. Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20; 119(2):261-8. 42. Boni A, Urbanek K, Nascimbene A, Hosoda T, Zheng H, Delucchi F, Amano K, Gonzalez A, Vitale S, Ojaimi C, Rizzi R, Bolli R, Yutzey KE, Rota M, Kajstura J, Anversa P, Leri A. Notch1 regulates the fate of cardiac progenitor cells. Proc Natl Acad Sci U S A. 2008 Oct 7; 105(40):15529-34. 43. Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, Magnuson N, Houser SR, Anversa P, Sussman MA. Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13889-94. 44. Kajstura J, Urbanek K, Rota M, Bearzi C, Hosoda T, Bolli R, Anversa P, Leri A. Cardiac stem cells and myocardial disease. J Mol Cell Cardiol. 2008 Oct; 45(4):505-13. 45. Rota M, Padin-Iruegas ME, Misao Y, De Angelis A, Maestroni S, Ferreira-Martins J, Fiumana E, Rastaldo R, Arcarese ML, Mitchell TS, Boni A, Bolli R, Urbanek K, Hosoda T, Anversa P, Leri A, Kajstura J. Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res. 2008 Jul 3; 103(1):107-16. 46. Siddiqi S, Gude N, Hosoda T, Muraski J, Rubio M, Emmanuel G, Fransioli J, Vitale S, Parolin C, D'Amario D, Schaefer E, Kajstura J, Leri A, Anversa P, Sussman MA. Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res. 2008 Jul 3; 103(1):89-97. 47. Kajstura J, Hosoda T, Bearzi C, Rota M, Maestroni S, Urbanek K, Leri A, Anversa P. The human heart: a self-renewing organ. Clin Transl Sci. 2008 May; 1(1):80-6. 48. Leri A, Kajstura J, Anversa P, Frishman WH. Myocardial regeneration and stem cell repair. Curr Probl Cardiol. 2008 Mar; 33(3):91-153. 49. Tillmanns J, Rota M, Hosoda T, Misao Y, Esposito G, Gonzalez A, Vitale S, Parolin C, Yasuzawa-Amano S, Muraski J, De Angelis A, Lecapitaine N, Siggins RW, Loredo M, Bearzi C, Bolli R, Urbanek K, Leri A, Kajstura J, Anversa P. Formation of large coronary arteries by cardiac progenitor cells. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1668-73. 50. Gonzalez A, Rota M, Nurzynska D, Misao Y, Tillmanns J, Ojaimi C, Padin-Iruegas ME, Müller P, Esposito G, Bearzi C, Vitale S, Dawn B, Sanganalmath SK, Baker M, Hintze TH, Bolli R, Urbanek K, Hosoda T, Anversa P, Kajstura J, Leri A. Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan. Circ Res. 2008 Mar 14; 102(5):597-606. 51. Ren J, Duan J, Thomas DP, Yang X, Sreejayan N, Sowers JR, Leri A, Kajstura J, Gao F, Anversa P. IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction. Am J Physiol Regul Integr Comp Physiol. 2008 Mar; 294(3):R793-802. 52. Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA. Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med. 2007 Dec; 13(12):1467-75. 53. Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, Bolli R, Houser SR, Leri A, Sussman MA, Anversa P. Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A. 2007 Nov 6; 104(45):17783-8. 54. Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A, Yasuzawa-Amano S, Trofimova I, Siggins RW, Lecapitaine N, Cascapera S, Beltrami AP, D'Alessandro DA, Zias E, Quaini F, Urbanek K, Michler RE, Bolli R, Kajstura J, Leri A, Anversa P. Human cardiac stem cells. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14068-73. 55. Rota M, Hosoda T, De Angelis A, Arcarese ML, Esposito G, Rizzi R, Tillmanns J, Tugal D, Musso E, Rimoldi O, Bearzi C, Urbanek K, Anversa P, Leri A, Kajstura J. The young mouse heart is composed of myocytes heterogeneous in age and function. Circ Res. 2007 Aug 17; 101(4):387-99. 56. Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F. Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5217-22. 57. Anversa P, Kajstura J, Leri A. If I can stop one heart from breaking. Circulation. 2007 Feb 20; 115(7):829-32. 58. Chen X, Wilson RM, Kubo H, Berretta RM, Harris DM, Zhang X, Jaleel N, MacDonnell SM, Bearzi C, Tillmanns J, Trofimova I, Hosoda T, Mosna F, Cribbs L, Leri A, Kajstura J, Anversa P, Houser SR. Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circ Res. 2007 Mar 2; 100(4):536-44. 59. Anversa P, Leri A, Rota M, Hosoda T, Bearzi C, Urbanek K, Kajstura J, Bolli R. Concise review: stem cells, myocardial regeneration, and methodological artifacts. Stem Cells. 2007 Mar; 25(3):589-601. 60. Li Q, Wu S, Li SY, Lopez FL, Du M, Kajstura J, Anversa P, Ren J. Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1398-403. 61. Kajstura J, Rota M, Urbanek K, Hosoda T, Bearzi C, Anversa P, Bolli R, Leri A. The telomere-telomerase axis and the heart. Antioxid Redox Signal. 2006 Nov-Dec; 8(11-12):2125-41. 62. Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA. Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):11946-51. 63. Leri A, Kajstura J, Anversa P. [Bone marrow cells and cardiac repair]. Arq Bras Cardiol. 2006 Aug; 87(2):71-2. 64. Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA. Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res. 2006 Aug 18; 99(4):381-8. 65. Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin-Iruegas ME, Esposito G, Vitale S, Urbanek K, Casarsa C, Giorgio M, Lüscher TF, Pelicci PG, Anversa P, Leri A, Kajstura J. Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ Res. 2006 Jul 7; 99(1):42-52. 66. Urbanek K, Cesselli D, Rota M, Nascimbene A, De Angelis A, Hosoda T, Bearzi C, Boni A, Bolli R, Kajstura J, Anversa P, Leri A. Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9226-31. 67. Davis ME, Hsieh PC, Takahashi T, Song Q, Zhang S, Kamm RD, Grodzinsky AJ, Anversa P, Lee RT. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8155-60. 68. Anversa P, Leri A, Kajstura J. Cardiac regeneration. J Am Coll Cardiol. 2006 May 2; 47(9):1769-76. 69. Dawn B, Guo Y, Rezazadeh A, Huang Y, Stein AB, Hunt G, Tiwari S, Varma J, Gu Y, Prabhu SD, Kajstura J, Anversa P, Ildstad ST, Bolli R. Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circ Res. 2006 Apr 28; 98(8):1098-105. 70. Anversa P, Kajstura J, Leri A, Bolli R. Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation. 2006 Mar 21; 113(11):1451-63. 71. Leri A, Hosoda T, Kajstura J, Anversa P. Heart failure and regenerative cardiology. Regen Med. 2006 Mar; 1(2):153-9. 72. Kajstura J, Bolli R, Sonnenblick EH, Anversa P, Leri A. Cause of death: suicide. J Mol Cell Cardiol. 2006 Apr; 40(4):425-37. 73. Kajstura J, Leri A, Bolli R, Anversa P. Endothelial progenitor cells: neovascularization or more? J Mol Cell Cardiol. 2006 Jan; 40(1):1-8. 74. Rota M, Boni A, Urbanek K, Padin-Iruegas ME, Kajstura TJ, Fiore G, Kubo H, Sonnenblick EH, Musso E, Houser SR, Leri A, Sussman MA, Anversa P. Nuclear targeting of Akt enhances ventricular function and myocyte contractility. Circ Res. 2005 Dec 9; 97(12):1332-41. 75. Anversa P, Rota M, Urbanek K, Hosoda T, Sonnenblick EH, Leri A, Kajstura J, Bolli R. Myocardial aging--a stem cell problem. Basic Res Cardiol. 2005 Nov; 100(6):482-93. 76. Leri A, Kajstura J, Anversa P. Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev. 2005 Oct; 85(4):1373-416. 77. Limana F, Germani A, Zacheo A, Kajstura J, Di Carlo A, Borsellino G, Leoni O, Palumbo R, Battistini L, Rastaldo R, Müller S, Pompilio G, Anversa P, Bianchi ME, Capogrossi MC. Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res. 2005 Oct 14; 97(8):e73-83. 78. Anversa P. Aging and longevity: the IGF-1 enigma. Circ Res. 2005 Sep 2; 97(5):411-4. 79. Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana F, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res. 2005 Sep 30; 97(7):663-73. 80. Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings BA, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 2005 Aug; 115(8):2128-38. 81. Linke A, Müller P, Nurzynska D, Casarsa C, Torella D, Nascimbene A, Castaldo C, Cascapera S, Böhm M, Quaini F, Urbanek K, Leri A, Hintze TH, Kajstura J, Anversa P. Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8966-71. 82. Urbanek K, Torella D, Sheikh F, De Angelis A, Nurzynska D, Silvestri F, Beltrami CA, Bussani R, Beltrami AP, Quaini F, Bolli R, Leri A, Kajstura J, Anversa P. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8692-7. 83. Leri A, Kajstura J, Anversa P. Identity deception: not a crime for a stem cell. Physiology (Bethesda). 2005 Jun; 20:162-8. 84. Leri A, Kajstura J, Anversa P. Regenerating the myocardium: a reality today. Can J Cardiol. 2005 Mar 15; 21(4):361-2. 85. Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, Torella D, Tang XL, Rezazadeh A, Kajstura J, Leri A, Hunt G, Varma J, Prabhu SD, Anversa P, Bolli R. Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci U S A. 2005 Mar 8; 102(10):3766-71. 86. Nadal-Ginard B, Anversa P, Kajstura J, Leri A. Cardiac stem cells and myocardial regeneration. Novartis Found Symp. 2005; 265:142-54; discussion 155-7, 204-11. 87. 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Lab Invest. 1978 May; 38(5):586-96. 320. Olivetti G, Anversa P, Rigamonti W, Vitali-Mazza L, Loud AV. Morphometry of the renal corpuscle during normal postnatal growth and compensatory hypertrophy. A light microscope study. J Cell Biol. 1977 Nov; 75(2 Pt 1):573-85. 321. Wiener J, Loud AV, Giacomelli F, Anversa P. Morphometric analysis of hypertension-induced hypertrophy of rat thoracic aorta. Am J Pathol. 1977 Sep; 88(3):619-34. 322. Vitali-Mazza L, Anversa P, Gandolfi A, Loud AV. Protein synthesis in the atrioventricular node during acute experimental cardiac hypertrophy in the rat. J Mol Cell Cardiol. 1976 Dec; 8(12):981-5. 323. Anversa P, Loud AV, Vitali-Mazza L. Morphometry and autoradiography of early hypertrophic changes in the ventricular myocardium of adult rat: an electron microscopic study. Lab Invest. 1976 Nov; 35(5):475-83. 324. Giacomelli F, Anversa P, Wiener J. Effect of angiotensin-induced hypertension on rat coronary arteries and myocardium. Am J Pathol. 1976 Jul; 84(1):111-38. 325. Anversa P, Vitali-Mazza L, Loud AV. Morphometric and autoradiographic study of developing ventricular and atrial myocardium in fetal rats. Lab Invest. 1975 Dec; 33(6):696-705. 326. Anversa P, Giacomelli J, Wiener J. Intercellular junctions of rat endocardium. Anat Rec. 1975 Nov; 183(3):477-83. 327. Anversa P, Vitali-Mazza L, Gandolfi A, Loud AV. Morphometry and autoradiography of early hypertrophic changes in the ventricular myocardium of adult rat. A light microscopic study. Lab Invest. 1975 Aug; 33(2):125-9. 328. Giacomelli F, Anversa P, Wiener J. Interendothelial gap size of subendocardial vs subepicardial capillaries. Microvasc Res. 1975 Jul; 10(1):38-42. 329. Hagopian M, Anversa P, Loud AV. Quantitative radioautographic localization of newly synthesized protein in the postnatal rat heart. J Mol Cell Cardiol. 1975 May; 7(5):357-67. 330. Hagopian M, Anversa P, Nunez EA. Specialized intercellular junctions in the intercalated disc of the bat heart. Anat Rec. 1974 Mar; 178(3):599-615. 331. Anversa P, Giacomelli F, Wiener J. Regional variation in capillary permeability of ventricular myocardium. Microvasc Res. 1973 Nov; 6(3):273-85. 332. Anversa P, Hagopian M, Loud AV. Quantitative radioautographic localization of protein synthesis in experimental cardiac hypertrophy. Lab Invest. 1973 Sep; 29(3):282-92. 333. Anversa P, Giacomelli F, Wiener J, Spiro D. Permeability properties of ventricular endocardium. Lab Invest. 1973 Jun; 28(6):728-34. 334. Vitali-Mazza L, Anversa P, Tedeschi F, Mastandrea R, Mavilla V, Visioli O. Ultrastructural basis of acute left ventricular failure from severe acute aortic stenosis in the rabbit. J Mol Cell Cardiol. 1972 Dec; 4(6):661-71. 335. Bordi C, Anversa P, Vitali-Mazza L. Ultrastructural study of a calcitonin-secreting tumor. Typhology of the tumor cells and origin of amyloid. Virchows Arch A Pathol Pathol Anat. 1972; 357(2):145-61. 336. Anversa P, Vitali-Mazza L, Visioli O, Marchetti G. Experimental cardiac hypertrophy: a quantitative ultrastructural study in the compensatory stage. J Mol Cell Cardiol. 1971 Dec; 3(3):213-27. 337. Astorri E, Chizzola A, Visioli O, Anversa P, Olivetti G, Vitali-Mazza L. Right ventricular hypertrophy--a cytometric study on 55 human hearts. J Mol Cell Cardiol. 1971 Jun; 2(2):99-110. 338. Tardini A, Anversa P, Bordi C, Bertaccini G, Impicciatore M. Ultrastructural and biochemical changes after marked caerulein stimulation of the exocrine pancreas in the dog. Am J Pathol. 1971 Jan; 62(1):35-56. 339. Tardini A, Anversa P, Bordi C. Ultrastructure of multiple pancreatic tumors in a case of Zollinger-Ellison syndrome. Am J Clin Pathol. 1969 Jul; 52(1):25-36. 340. Vitali Mazza L, Anversa P, Morgutti L, Toso A. Changes of the myocardial ultrastructure during open heart surgery with extracorporeal circulation. J Cardiovasc Surg (Torino). 1969 May-Jun; 10(3):212-28. 341. Anversa P, Dall'Orso E, Vitali-Mazza L, Mastandrea R, Visioli O. [Ultrastructural bases of myocardial contractility: the passive distensibility of the sarcomere, as an index of ventricular function. Description of the method of biometrical analysis of the left ventricle of the rabbit]. Z Zellforsch Mikrosk Anat. 1969; 94(2):181-93. 342. Chizzola A, Astorri E, Bini L, Visioli O, Anversa P, Dall'Orso E, Vitali-Mazza L. [The structural bases of left ventricular hypertrophy. Cytometric studies]. Folia Cardiol. 1968 Sep-Oct; 27(5):254-69. 343. Astorri E, Bini L, Chizzola A, Visioli O, Anversa P, Dall'Orso E, Vitali-Mazza L. [Histocytometric study of the subepicardial layer of the left ventricle of heart of progressively increasing weights]. Riv Anat Patol Oncol. 1967 Jul-Aug; 32(1):1-12. 344. Dall'Orso E, Anversa P. [Cardiac sarcoidosis (report of an anatomo-clinical case)]. Riv Anat Patol Oncol. 1967 Apr; 31(4):417-31. 345. Chizzola A, Astorri E, Bini L, Visioli O, Anversa P, Dall'Orso E, Vitali-Mazza L. [Methodological premises in the cytometric study of the myocardium]. Riv Anat Patol Oncol. 1967 Apr; 31(4):345-67. 346. Vitali-Mazza L, Anversa P, Visioli O. [Ultrastructural changes in the myocardium of rats on a polyunsaturated fatty acid deficient diet]. Virchows Arch Pathol Anat Physiol Klin Med. 1967 Jan 11; 342(1):38-49.

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