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Paul D. Allen, MD, PhD
Anesthesiologist, Brigham and Women's Hospital
Professor of Anaesthesia, Emeritus, Harvard Medical School

Brigham and Women's Hospital
Department of Anesthesiology, Perioperative and Pain Medicine
75 Francis Street
Boston, MA 02115

Research Location: Thorn Research Building


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Research Narrative:

Investigative Interests: Ryanodine Receptor, Calcium, Calcium Signaling, Calcium Channels, Gene Therapy


Education:
University of Florida, 1973, PhD
Boston University, 1967, MD

Honors/Awards:
Academy of Anesthesia Mentors
FAER Honorary Speaker
Paul D. Allen Chair in Anesthesia Research

Lab Members:
Jose Rafael Lopez, MD, Ph.D
Claudio Perez, PhD
Karen Westerman, PhD
James Fessenden, PhD
Yaming Wang , MD

Collaborators:
Isaac N Pessah, UC Davis, Shared Grants and PPG

Kurt G. Beam, University of Colorado Health Science CEnter, Shared Grants and PPG

Clara Franzini-Armstrong, University of Pennsylvania, Shared Grants and PPG


Resources:
Spinning disc confocal microscope
High Speed Ca2+ imaging system

Other Professional Activities:
Editorial Board, Journal of Biologic Chemistry
Reviewer and Chairperson, NIH Study Section, NIAMS

Publications (Pulled from Harvard Catalyst Profiles):

1. Manno C, Sztretye M, Figueroa L, Allen PD, Ríos E. Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle. J Physiol. 2013 Jan 15; 591(2):423-42.

2. Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam KG, Samsó M. Three-dimensional localization of the a and ß subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel. J Biol Chem. 2012 Dec 21; 287(52):43853-61.

3. Boncompagni S, Thomas M, Lopez JR, Allen PD, Yuan Q, Kranias EG, Franzini-Armstrong C, Perez CF. Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. PLoS One. 2012; 7(7):e39962.

4. Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN, Molinski TF, López JR, Beam KG, Allen PD. Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7923-8.

5. Cai WF, Pritchard T, Florea S, Lam CK, Han P, Zhou X, Yuan Q, Lehnart SE, Allen PD, Kranias EG. Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovasc Res. 2012 May 01; 94(2):333-41.

6. Olojo RO, Ziman AP, Hernández-Ochoa EO, Allen PD, Schneider MF, Ward CW. Mice null for calsequestrin 1 exhibit deficits in functional performance and sarcoplasmic reticulum calcium handling. PLoS One. 2011; 6(12):e27036.

7. Eltit JM, Li H, Ward CW, Molinski T, Pessah IN, Allen PD, Lopez JR. Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7046-51.

8. Eltit JM, Szpyt J, Li H, Allen PD, Perez CF. Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction. Cell Calcium. 2011 Feb; 49(2):128-35.

9. Feng W, Barrientos GC, Cherednichenko G, Yang T, Padilla IT, Truong K, Allen PD, Lopez JR, Pessah IN. Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice. Mol Pharmacol. 2011 Mar; 79(3):420-31.

10. Giulivi C, Ross-Inta C, Omanska-Klusek A, Napoli E, Sakaguchi D, Barrientos G, Allen PD, Pessah IN. Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice. J Biol Chem. 2011 Jan 07; 286(1):99-113.