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Claudio Fernando Perez, PhD
Assistant Professor of Anaesthesia, Harvard Medical School

Brigham and Women's Hospital
Department of Anesthesiology, Perioperative and Pain Medicine
75 Francis Street
Boston, MA 02115

Research Location: Thorn Research Building

Research Email: cperez@bwh.harvard.edu

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Research Narrative:

Investigative Interests: Calcium Homeostasis, Calcium Imaging, Molecular Biology, Electrophysiology


Education:
University of Chile, 1999, Ph.D.
PhD

Publications (Pulled from Harvard Catalyst Profiles):

1. Perez CF, Eltit JM, Lopez JR, Bodnár D, Dulhunty AF, Aditya S, Casarotto MG. Functional and structural characterization of a novel malignant hyperthermia-susceptible variant of DHPR-ß1a subunit (CACNB1). Am J Physiol Cell Physiol. 2018 03 01; 314(3):C323-C333.

2. Cho CH, Woo JS, Perez CF, Lee EH. A focus on extracellular Ca2+ entry into skeletal muscle. Exp Mol Med. 2017 09 15; 49(9):e378.

3. Mahalingam M, Perez CF, Fessenden JD. Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor a1S Subunit Reveals Conformational Differences Induced by Binding of the ß1a Subunit. J Biol Chem. 2016 Jun 24; 291(26):13762-70.

4. Eltit JM, Franzini-Armstrong C, Perez CF. Amino acid residues 489-503 of dihydropyridine receptor (DHPR) ß1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor. J Biol Chem. 2014 Dec 26; 289(52):36116-24.

5. Altamirano F, Perez CF, Liu M, Widrick J, Barton ER, Allen PD, Adams JA, Lopez JR. Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. PLoS One. 2014; 9(9):e106590.

6. Chen Y, Xue S, Zou J, Lopez JR, Yang JJ, Perez CF. Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor. Biochem J. 2014 Jun 01; 460(2):261-71.

7. Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam KG, Samsó M. Three-dimensional localization of the a and ß subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel. J Biol Chem. 2012 Dec 21; 287(52):43853-61.

8. Boncompagni S, Thomas M, Lopez JR, Allen PD, Yuan Q, Kranias EG, Franzini-Armstrong C, Perez CF. Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. PLoS One. 2012; 7(7):e39962.

9. Perez CF. On the footsteps of Triadin and its role in skeletal muscle. World J Biol Chem. 2011 Aug 26; 2(8):177-83.

10. Eltit JM, Szpyt J, Li H, Allen PD, Perez CF. Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction. Cell Calcium. 2011 Feb; 49(2):128-35.