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Elisabeth M. Battinelli, MD
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

Dr. Battinelli joined the Hematology Division in 2008 after completing her fellowship at the Beth Israel Deaconess Medical Center. Her research focuses on the role of the platelet in the process of angiogenesis. It is estimated that more than 500 million people worldwide could benefit from treatments that regulate angiogenesis. Platelets contain many pro- and anti-angiogenic factors; however, their role in angiogenesis is not well characterized. Recently, Dr. Battinelli and her colleagues have shown that platelets store these pro- and anti-angiogenic regulatory proteins in separate distinct alpha granules that are differentially released. These observations have broad implications for platelet biology, suggesting an important role for platelets beyond their well-recognized contribution to hemostasis. Dr. Battinelli is interested in defining how platelets acquire, store, transport, and deliver these angiogenic regulatory proteins and how anti-angiogenic therapies influence this process.

Recent Publications:

Battinelli EM, Hartwig JH, Italiano JE. Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis. Curr Opin Hematol. 2007, 14:419-26.

Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S,Folkman J, Klement GL. Angiogenesis is regulated by a novel mechanism: Pro- and antiangiogenic proteins are organized into separate platelet {alpha}-granules and differentially released. Blood. 2008,111:1227-1233.

Boston University School of Medicine, 2001, MD
Oxford University, 1992, MSc

Publications (Pulled from Harvard Catalyst Profiles):

1. Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE, Battinelli EM. Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Adv. 2019 01 22; 3(2):198-211.

2. Hall KT, Buring JE, Mukamal KJ, Vinayaga Moorthy M, Wayne PM, Kaptchuk TJ, Battinelli EM, Ridker PM, Sesso HD, Weinstein SJ, Albanes D, Cook NR, Chasman DI. COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials. J Natl Cancer Inst. 2019 Jan 08.

3. Simmons DP, Herskovits AZ, Battinelli EM, Schur PH, Lemire SJ, Dorfman DM. Lupus anticoagulant testing using two parallel methods detects additional cases and predicts persistent positivity. Clin Chem Lab Med. 2018 07 26; 56(8):1289-1296.

4. Takagi S, Tsukamoto S, Park J, Johnson KE, Kawano Y, Moschetta M, Liu CJ, Mishima Y, Kokubun K, Manier S, Salem KZ, Huynh D, Sacco A, Forward J, Roccaro AM, Battinelli EM, Ghobrial IM. Platelets Enhance Multiple Myeloma Progression via IL-1ß Upregulation. Clin Cancer Res. 2018 05 15; 24(10):2430-2439.

5. Machlus KR, Battinelli EM. RBCs pin platelets against the (thrombus) wall. Blood. 2017 05 04; 129(18):2460-2461.

6. Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE, Battinelli EM. Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis. Arterioscler Thromb Vasc Biol. 2017 04; 37(4):664-674.

7. Hollenhorst MA, Battinelli EM. Thrombosis, Hypercoagulable States, and Anticoagulants. Prim Care. 2016 Dec; 43(4):619-635.

8. Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE, Battinelli EM. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. 2016 Feb 18; 127(7):921-6.

9. Battinelli EM. Procoagulant Platelets: Not Just Full of Hot Air. Circulation. 2015 Oct 13; 132(15):1374-6.

10. Battinelli EM. TTP and pregnancy. Blood. 2014 Mar 13; 123(11):1624-5.