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Nancy Berliner, MD
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Hematology
75 Francis Street
Boston, MA 02115


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Research Narrative:

The main focus of the research in Dr. Berliner’s laboratory has been on the dissection of the molecular pathways involved in differentiation of granulocytes. Early studies focused on understanding the transcriptional regulation of neutrophil-specific gene expression. This has expanded into studies of the disruption of myeloid gene expression in specific granule deficiency, myelodysplasia (MDS), and acute myeloid leukemia (AML), as well as dissection of the abnormalities of neutrophil function seen in a variety of neutrophil disorders. These studies have been facilitated by the development of factor-dependent cell lines that can be used to model normal and abnormal neutrophil maturation. More recent studies are also focusing on the role of cellular stress responses in the disruption of hematopoietic cell differentiation in myelodysplasia.

Another set of studies focus on the role of inflammatory cytokines in the anemia of the elderly and in modulating the natural history of MDS. Although it is clear that anemia is an independent risk factor associated with reduced survival in patients over age 65, the etiology of anemia in at least one third of these patients is unknown, as is the pathogenesis by which it leads to physical decline and death. The central hypothesis of these studies is that in the absence of nutritional deficiency, anemia in the elderly usually reflects a proinflammatory state with an associated anemia of inflammation. Furthermore, these inflammatory changes also have an impact on the degree of anemia seen in patients with MDS.

Recent Publications:

Zou S, Glynn S, Kuritzkes D, Shah M, Cook N, Berliner N. Hematopoietic cell transplantation and HIV cure: where we are and what next? Blood. 2013 Oct 31; 122(18):3111-5.

Rego EM, Kim HT, Ruiz-Argüelles GJ, Undurraga MS, Uriarte Mdel R, Jacomo RH, Gutiérrez-Aguirre H, Melo RA, Bittencourt R, Pasquini R, Pagnano K, Fagundes EM, Chauffaille Mde L, Chiattone CS, Martinez L, Meillón LA, Gómez-Almaguer D, Kwaan HC, Garcés-Eisele J, Gallagher R, Niemeyer CM, Schrier SL, Tallman M, Grimwade D, Ganser A, Berliner N, Ribeiro RC, Lo-Coco F, Löwenberg B, Sanz MA. Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL. Blood. 2013 Mar 14; 121(11):1935-43.

Redig AJ, Berliner N. Pathogenesis and clinical implications of HIV-related anemia in 2013. Hematology Am Soc Hematol Educ Program. 2013; 2013:377-81.

Khanna-Gupta A, Abayasekara N, Levine M, Sun H, Virgilio M, Nia N, Halene S, Sportoletti P, Jeong JY, Pandolfi PP, Berliner N. Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein a activity: implications in myelodysplastic syndrome and acute myeloid leukemia. J Biol Chem. 2012 Sep 21; 287(39):32728-37.

Payne EM, Virgilio M, Narla A, Sun H, Levine M, Paw BH, Berliner N, Look AT, Ebert BL, Khanna-Gupta A. L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood. 2012 Sep 13; 120(11):2214-24.


Education:
Yale University School of Medicine, 1979, MD

Honors/Awards:
Fellow, American College of Physicians, 2009
President, American Society of Hematology, 2009
Institute of Medicine, 2010
American Clinical and Climatological Association, 2012
American Society for Clinical Investigation, 1994
Association of American Physicians, 2004
Stohlman Prize, Leukemia Society of America, 1997

Publications (Pulled from Harvard Catalyst Profiles):

1. Lucena-Araujo AR, Coelho-Silva JL, Pereira-Martins DA, Silveira DR, Koury LCA, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria AB, Kerbauy FR, Chauffaille ML, Bendit I, Rocha V, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo Coco F, Sanz MA, Berliner N, Rego EM. Combining gene mutation with gene expression analysis improves outcomes prediction in acute promyelocytic leukemia. Blood. 2019 Jul 10.

2. La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan MB, Kumar A, van Laar JAM, Lachmann G, Nichols KE, Ramanan AV, Wang Y, Wang Z, Janka G, Henter JI. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood. 2019 Jun 06; 133(23):2465-2477.

3. Berliner N, Coates TD. Introduction to a review series on human neutrophils. Blood. 2019 May 16; 133(20):2111-2112.

4. Connell NT, Berliner N. Fostamatinib for the treatment of chronic immune thrombocytopenia. Blood. 2019 May 09; 133(19):2027-2030.

5. Rahmani M, Fortin BM, Berliner N, Issa N, Neuberg D, Kaufman RM, Gansner JM. CD4+ T-cell lymphopenia in frequent platelet donors who have ceased platelet donation for at least 1 year. Transfusion. 2019 May; 59(5):1644-1647.

6. Gansner JM, Berliner N. The rheumatology/hematology interface: CAPS and MAS diagnosis and management. Hematology Am Soc Hematol Educ Program. 2018 11 30; 2018(1):313-317.

7. Gansner JM, Rahmani M, Jonsson AH, Fortin BM, Brimah I, Ellis M, Smeland-Wagman R, Li ZJ, Schenkel JM, Brenner MB, Yefidoff-Freedman R, Sloan SR, Berliner N, Issa NC, Baden LR, Longo DL, Wesemann DR, Neuberg D, Rao DA, Kaufman RM. Plateletpheresis-associated lymphopenia in frequent platelet donors. Blood. 2019 Feb 07; 133(6):605-614.

8. Lucena-Araujo AR, Pereira-Martins DA, Koury LC, Franca-Neto PL, Coelho-Silva JL, de Deus Wagatsuma VM, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Chiattone CS, Fagundes EM, Chauffaille ML, Schrier SL, Tallman MS, Ribeiro RC, Grimwade D, Ganser A, Löwenberg B, Lo-Coco F, Sanz MA, Berliner N, Rego EM. Clinical impact of BAALC expression in high-risk acute promyelocytic leukemia. Blood Adv. 2017 Sep 26; 1(21):1807-1814.

9. Al-Samkari H, Berliner N. Hemophagocytic Lymphohistiocytosis. Annu Rev Pathol. 2018 01 24; 13:27-49.

10. Gansner JM, Achebe MM, Gray KJ, Yefidoff-Freedman R, Labovitis E, Parnes A, Connors JM, Connell NT, Discenza MN, Handin RI, Berliner N, Shimamura A, Ginsburg ES, Smith NA. Pregnancy outcomes in inherited bone marrow failure syndromes. Blood. 2017 10 05; 130(14):1671-1674.