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Jonathan S. Williams, MD, MMSc
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Endocrinology
75 Francis Street
Boston, MA 02115

Phone: 617-278-0882
Fax: 617-732-5764
Email: jwilliams5@partners.org

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Research Narrative:

Our research group seeks to understand the interplay between environmental factors and genetics and their contribution to cardiometabolic diseases.  We have active, federally funded, research protocols exploring the effect of dietary salt on insulin resistance, obesity, hypertension, and heart failure using both human subjects and laboratory animal model research platforms. Ultimatley, our efforts aim to minimize human suffering by identifying factors that place individuals at risk for developing complex heritable diseases (prevention) and also improving treatment programs once disease is detected (precision medicine).  


Education:
Harvard Medical Schoool, 2004, MMSc
Hahnemann University, 1998, MD
Brigham Young University, 1992, BS

Honors/Awards:
Alpha Omega Alpha Medical Honor Society
Brigham and Women's Hospital, Early Career Mentoring Award

Other Professional Activities:
Associate Editor 2011-2015, Metabolism: Clinical and Experimental
NIH Study Section reviewer 2010, 2014, NIDDK
Board Member, Association for Patient-oriented Research

Publications (Pulled from Harvard Catalyst Profiles):

1. Haas AV, Hopkins PN, Brown NJ, Pojoga LH, Williams JS, Adler GK, Williams GH. Higher urinary cortisol levels associate with increased cardiovascular risk. Endocr Connect. 2019 Jun 01; 8(6):634-640.

2. Huang Y, Ting PY, Yao TM, Homma T, Brooks D, Katayama Rangel I, Adler GK, Romero JR, Williams JS, Pojoga LH, Williams GH. Histone demethylase LSD1 deficiency and biological sex: impact on blood pressure and aldosterone production. J Endocrinol. 2019 Feb 01; 240(2):111-122.

3. Zitting KM, Vujovic N, Yuan RK, Isherwood CM, Medina JE, Wang W, Buxton OM, Williams JS, Czeisler CA, Duffy JF. Human Resting Energy Expenditure Varies with Circadian Phase. Curr Biol. 2018 Nov 19; 28(22):3685-3690.e3.

4. Zhang X, Frame AA, Williams JS, Wainford RD. GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study. Physiol Genomics. 2018 09 01; 50(9):724-725.

5. Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR. Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II. Hypertension. 2018 06; 71(6):1083-1090.

6. Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZ. Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion. TH Open. 2018 Jan; 2(1):e49-e53.

7. Zaheer S, Taquechel K, Brown JM, Adler GK, Williams JS, Vaidya A. A randomized intervention study to evaluate the effect of calcitriol therapy on the renin-angiotensin system in diabetes. J Renin Angiotensin Aldosterone Syst. 2018 Jan-Mar; 19(1):1470320317754178.

8. Gupta T, Connors M, Tan JW, Manosroi W, Ahmed N, Ting PY, Garza AE, Romero JR, Hopkins PN, Williams JS, Williams GH. Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens. 2017 Dec 08; 31(1):124-131.

9. Tan JW, Gupta T, Manosroi W, Yao TM, Hopkins PN, Williams JS, Adler GK, Romero JR, Williams GH. Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight. 2017 12 07; 2(23).

10. Manosroi W, Tan JW, Rariy CM, Sun B, Goodarzi MO, Saxena AR, Williams JS, Pojoga LH, Lasky-Su J, Cui J, Guo X, Taylor KD, Chen YI, Xiang AH, Hsueh WA, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Seely EW. The Association of Estrogen Receptor-ß Gene Variation With Salt-Sensitive Blood Pressure. J Clin Endocrinol Metab. 2017 11 01; 102(11):4124-4135.