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Benjamin Raby, MD, MPH
Associate Physician, Brigham and Women's Hospital
Leila and Irving Perlmutter Associate Professor of Pediatrics, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Channing Division of Network Medicine
75 Francis Street
Boston, MA 02115

Email: braby@partners.org
Research Email: rebar@channing.harvard.edu

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Research Narrative:

I am a pulmonologist and genetic epidemiologist with an interest in the genetics of lung disease. I am Director of the BWH Pulmonary Genetics Center, a first-of-its kind clinical and research center that serves patients with suspected genetic pulmonary disorders. My research focuses primarily on identifying the molecular determinants of asthma in human populations. I have developed four NIH-funded studies that use genome-wide approaches. “Genetics and Gene Expression Profiling in Asthmaaims to identify asthma-associated regulatory genetic variants. I have developed gene expression signatures for asthma-associated traits and methods to facilitate expression quantitative trait locus mapping studies. These efforts resulted in identification of regulatory variants that influence the expression of 1,585 genes, including novel asthma susceptibility variants, and have developed a pipeline to functionally characterize the identified asthma genes. The second project, “The Asthma BioRepository for Integrative Genomics Research”, is a nation-wide effort to establish a publicly accessible repository of cell lines from 1,500 asthmatic and healthy subjects, accompanied by genome-wide genotype, gene expression and methylation profiles for all 1,500 subjects to facilitate integrative, systems-based approaches for the study of asthma and other traits. The third project, “Structural Genetic Variation in Asthma”, is supporting a genome-wide association study of copy number variation (CNVs) in asthma. The fourth, "Integrative Genomics of Acute Asthma Control" focuses on leveraging clinical, genomic and environmental data to understand the molecular determinants of suboptimal asthma control. I am also a founding member of the EVE Asthma Consortium, and collaborate on a variety of asthma and COPD projects.



Education:
Harvard School of Public Health, 2003, MPH
McGill University Faculty of Medicine, 1995, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Wang AL, Gruzieva O, Qiu W, Merid SK, Celedón JC, Raby BA, Söderhäll C, DeMeo DL, Weiss ST, Melén E, Tantisira KG. DNA methylation is associated with inhaled corticosteroid response in persistent childhood asthmatics. Clin Exp Allergy. 2019 Jun 12.

2. Boone PM, Scott RM, Marciniak SJ, Henske EP, Raby BA. The Genetics of Pneumothorax. Am J Respir Crit Care Med. 2019 Jun 01; 199(11):1344-1357.

3. Raby BA. Asthma severity, nature or nurture: genetic determinants. Curr Opin Pediatr. 2019 Jun; 31(3):340-348.

4. Stone G, Choi A, Meritxell O, Gorham J, Heydarpour M, Seidman CE, Seidman JG, Aranki SF, Body SC, Carey VJ, Raby BA, Stranger BE, Muehlschlegel JD. Sex differences in gene expression in response to ischemia in the human left ventricular myocardium. Hum Mol Genet. 2019 May 15; 28(10):1682-1693.

5. Cahill KN, Cui J, Kothari P, Murphy K, Raby BA, Singer J, Israel E, Boyce JA, Laidlaw TM. Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial. Am J Respir Crit Care Med. 2019 Apr 12.

6. D'Andrea E, Choudhry NK, Raby B, Weinhouse GL, Najafzadeh M. A bronchial-airway gene-expression classifier to improve the diagnosis of lung cancer: Clinical outcomes and cost-effectiveness analysis. Int J Cancer. 2019 Apr 11.

7. Wang AL, Qiu W, DeMeo DL, Raby BA, Weiss ST, Tantisira KG. DNA methylation is associated with improvement in lung function on inhaled corticosteroids in pediatric asthmatics. Pharmacogenet Genomics. 2019 Apr; 29(3):65-68.

8. Raby BA. Asthma severity, nature or nurture: genetic determinants. Curr Opin Pediatr. 2019 Mar 20.

9. Stubbs BJ, Gopaulakrishnan S, Glass K, Pochet N, Everaert C, Raby B, Carey V. TFutils: Data structures for transcription factor bioinformatics. F1000Res. 2019; 8:152.

10. Kogan V, Millstein J, London SJ, Ober C, White SR, Naureckas ET, Gauderman WJ, Jackson DJ, Barraza-Villarreal A, Romieu I, Raby BA, Breton CV. Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search. Hum Hered. 2018; 83(3):130-152.