Skip to contents

Luminita Pojoga, MS, PhD
Associate Physiologist, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Endocrinology
75 Francis Street
Boston, MA 02115

Research Location: Eugene Braunwald Research Center


Edit Profile


Research Narrative:

The overall focus of our lab is to decipher molecular and physiological mechanisms of cardiovascular and metabolic dysfunction, and to identify novel therapeutic targets for these conditions. In a translational approach, we use cells, transgenic animals and naturally occurring genetic variations in humans to assess mechanisms of cardiometabolic disease. For example, we found that genetic variation in the human caveolin-1 (cav-1) gene (leading to cav-1 insufficiency) or cav-1 deficiency in mice associate with severe cardiometabolic impairments, due in part to excessive aldosterone signaling. Treatment with an MR blocker improves cardiovascular and metabolic function in cav-1 KO mice, and therefore may be particularly valuable in individuals with low cav-1 expression, as identified by cav-1 genotype. Another example from our translational research program is the study of beta-2 adrenergic receptor (B2AR) mechanisms of adrenal steroid production. Starting from a human B2AR risk allele that associates with salt sensitive hypertension and increased aldosterone levels - we have now found that dietary sodium selectively influences coupling between B2AR and G-protein subtypes in the adrenal, thus triggering activation of alternate salt-sensitive B2AR pathways. Our ongoing studies are aimed at understanding underlying mechanisms of CVM disease associated with variants and finally to identify personalized treatment strategies for individuals that carry variants such as the cav-1 and B2AR risk alleles.


Education:
Clemson University, 2003, Ph.D.
Claude Bernard University Lyon I, 1997, MS

Publications (Pulled from Harvard Catalyst Profiles):

1. Haas AV, Hopkins PN, Brown NJ, Pojoga LH, Williams JS, Adler GK, Williams GH. Higher urinary cortisol levels associate with increased cardiovascular risk. Endocr Connect. 2019 Jun 01; 8(6):634-640.

2. Brooks DL, Garza AE, Katayama IA, Romero JR, Adler GK, Pojoga LH, Williams GH. Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice. Endocrinology. 2019 Apr 01; 160(4):716-728.

3. Huang Y, Ting PY, Yao TM, Homma T, Brooks D, Katayama Rangel I, Adler GK, Romero JR, Williams JS, Pojoga LH, Williams GH. Histone demethylase LSD1 deficiency and biological sex: impact on blood pressure and aldosterone production. J Endocrinol. 2019 Feb 01; 240(2):111-122.

4. Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR. Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II. Hypertension. 2018 06; 71(6):1083-1090.

5. Mayurasakorn K, Hasanah N, Homma T, Homma M, Rangel IK, Garza AE, Romero JR, Adler GK, Williams GH, Pojoga LH. Caloric restriction improves glucose homeostasis, yet increases cardiometabolic risk in caveolin-1-deficient mice. Metabolism. 2018 06; 83:92-101.

6. Manosroi W, Tan JW, Rariy CM, Sun B, Goodarzi MO, Saxena AR, Williams JS, Pojoga LH, Lasky-Su J, Cui J, Guo X, Taylor KD, Chen YI, Xiang AH, Hsueh WA, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Seely EW. The Association of Estrogen Receptor-ß Gene Variation With Salt-Sensitive Blood Pressure. J Clin Endocrinol Metab. 2017 11 01; 102(11):4124-4135.

7. Homma T, Homma M, Huang Y, Mayurasakorn K, Rodi NM, Hamid AAA, Hurwitz S, Yao T, Adler GK, Pojoga LH, Williams GH, Romero JR. Combined Salt and Caloric Restrictions: Potential Adverse Outcomes. J Am Heart Assoc. 2017 Oct 11; 6(10).

8. Chong C, Hamid A, Yao T, Garza AE, Pojoga LH, Adler GK, Romero JR, Williams GH. Regulation of aldosterone secretion by mineralocorticoid receptor-mediated signaling. J Endocrinol. 2017 03; 232(3):525-534.

9. Baudrand R, Gupta N, Garza AE, Vaidya A, Leopold JA, Hopkins PN, Jeunemaitre X, Ferri C, Romero JR, Williams J, Loscalzo J, Adler GK, Williams GH, Pojoga LH. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016 09 28; 5(10).

10. Baudrand R, Pojoga L, Vaidya A, Garza A, Vöhringer P, Jeunemaitre X, Hopkins P, Yao T, Williams J, Adler G, Williams G. Response to Letter Regarding Article, "Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects". Circulation. 2016 Apr 19; 133(16):e606.