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Stephen Elledge, PhD
Gregor Mendel Professor of Genetics and of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
75 Francis Street
Boston, MA 02115

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Research Narrative:

Stephen Elledge, PhD, is interested in understanding cell cycle control, the cellular response to DNA damage and how the proteome is remodeled by ubiquitin-mediated proteolysis. He also develops genetic technologies to aid in gene and drug discovery. He developed new methods to identify targets of autoimmunity. Recently he has applied genetic and computational strategies to understand how aneuploidy drives tumorigenesis and how genetics can uncover vulnerabilities in cancer cells.

Publications (Pulled from Harvard Catalyst Profiles):

1. Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ. T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 2019 Aug 08; 178(4):1016-1028.e13.

2. Harrison GF, Sanz J, Boulais J, Mina MJ, Grenier JC, Leng Y, Dumaine A, Yotova V, Bergey CM, Nsobya SL, Elledge SJ, Schurr E, Quintana-Murci L, Perry GH, Barreiro LB. Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists. Nat Ecol Evol. 2019 Aug; 3(8):1253-1264.

3. Irving AT, Rozario P, Kong PS, Luko K, Gorman JJ, Hastie ML, Chia WN, Mani S, Lee BP, Smith GJD, Mendenhall IH, Larman HB, Elledge SJ, Wang LF. Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia. Cell Mol Life Sci. 2019 Jul 27.

4. Timms RT, Zhang Z, Rhee DY, Harper JW, Koren I, Elledge SJ. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science. 2019 07 05; 365(6448).

5. Zirin J, Ni X, Sack LM, Yang-Zhou D, Hu Y, Brathwaite R, Bulyk ML, Elledge SJ, Perrimon N. Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Proc Natl Acad Sci U S A. 2019 Jul 16; 116(29):14614-14619.

6. Bender Ignacio RA, Dasgupta S, Stevens-Ayers T, Kula T, Hill JA, Lee SJ, Mielcarek M, Duerr A, Elledge SJ, Boeckh M. Comprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation. Blood. 2019 Aug 08; 134(6):503-514.

7. Isnard P, Kula T, Avettand Fenoel V, Anglicheau D, Terzi F, Legendre C, Elledge SJ, Canaud G. Temporal virus serological profiling of kidney graft recipients using VirScan. Proc Natl Acad Sci U S A. 2019 May 28; 116(22):10899-10904.

8. Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, Ruczinski I, Larman HB. Comprehensive Profiling of HIV Antibody Evolution. Cell Rep. 2019 Apr 30; 27(5):1422-1433.e4.

9. Haigis KM, Cichowski K, Elledge SJ. Tissue-specificity in cancer: The rule, not the exception. Science. 2019 Mar 15; 363(6432):1150-1151.

10. Barber KW, Elledge SJ. Sequencer Hacking Unlocks Quantitative Protein Studies. Mol Cell. 2019 03 07; 73(5):863-865.