Gad Asher Marshall, MD
|
|
 |
Associate Neurologist, Brigham and Women's Hospital
Assistant Professor of Neurology, Harvard Medical School
Brigham and Women's Hospital Department of Neurology 75 Francis Street Boston, MA 02115
|
|
Research Narrative:
I received my medical degree from Boston University School of Medicine in 2000. I subsequently developed my interest in Alzheimer’s disease during neurology residency in Pittsburgh, under the guidance of Drs. Daniel Kaufer, Nicolaas Bohnen, and Steven DeKosky, and dementia fellowship in Los Angeles, with Drs. Jeffrey Cummings and Harry Vinters as my mentors. This has led me to my current faculty position at Brigham and Women’s Hospital and Massachusetts General Hospital, where I have had the fortune of working with Drs. Reisa Sperling and Keith Johnson, focusing on clinical trials and neuroimaging biomarkers in the Alzheimer’s disease spectrum.
I am currently Associate Medical Director of Clinical Trials at the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital; Associate Neurologist at Brigham and Women’s Hospital; Assistant in Neurology at Massachusetts General Hospital; and Assistant Professor of Neurology at Harvard Medical School. I have been site principal investigator for multiple clinical trials of amyloid-modifying drugs in Alzheimer’s disease. My research has focused on clinical correlates of activities of daily living, apathy, and executive function with PiB and FDG PET and CSF biomarkers. Most recently, I have been exploring the association between instrumental activities of daily living, executive function, and PiB PET in mild cognitive impairment. Building on my previous work, I am now developing a new scale of complex activities of daily living that will detect the earliest functional deficits at the stage of preclinical Alzheimer’s disease.
|
|
Education: |
MD
|
|
Publications (Pulled from Harvard Catalyst Profiles):
1. Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology. 2017 May 02; 88(18):1759-1767.
2. Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid-ß. Alzheimers Dement. 2017 Feb 28.
3. Gatchel JR, Donovan NJ, Locascio JJ, Becker JA, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease. Am J Geriatr Psychiatry. 2017 Jan 04.
4. Hsu D, Marshall GA. Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward. Curr Alzheimer Res. 2017; 14(4):426-440.
5. Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA. Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults. JAMA Psychiatry. 2016 Dec 01; 73(12):1230-1237.
6. Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA. Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals. JAMA Neurol. 2016 Oct 01; 73(10):1185-1191.
7. Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. 2016 Aug 30; 87(9):920-6.
8. Hsu DC, Mormino EC, Schultz AP, Amariglio RE, Donovan NJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly. J Alzheimers Dis. 2016 Jun 18; 53(3):1097-105.
9. Donovan NJ, Wu Q, Rentz DM, Sperling RA, Marshall GA, Glymour MM. Loneliness, depression and cognitive function in older U.S. adults. Int J Geriatr Psychiatry. 2017 May; 32(5):564-573.
10. Marshall GA. Meet Our Associate Editor. Curr Alzheimer Res. 2016; 13(8):845.
|
|