Myron Spector, PhD
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Senior Scientist, Brigham and Women's Hospital
Professor of Orthopedic Surgery (Biomaterials), Harvard Medical School
Brigham and Women's Hospital
Department of Orthopedic Surgery
75 Francis Street
Boston, MA 02115
Research Location: Medical Research Building
Research Email: mspector@rics.bwh.harvard.edu
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| Research Narrative:
Myron Spector, Director of the Tissue Engineering Laboratories/Orthopaedic Research Laboratories has over 30 years of experience working in the biomaterials/tissue engineering field. He has directed his attention in recent years to the development of collagen-glycosaminoglycan sponge-like scaffolds and injectable biopolymer gels for musculoskeletal and nerve tissue engineering. He is the author of over 250 papers in peer-reviewed scientific journals, is Editor-in-Chielf of Biomedical Materials, and is a member of the Editorial Board of 8 journals.
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| Education: |
Carnegie-Mellon University, 1971, Ph.D.
PhD
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| Honors/Awards: |
2001 Elizabeth Winston-Lanier Kappa Delta Award from the American Academy of Orthopaedic Surgeons/Orthopaedic Research Society for the work entitled, “Expression of Muscle Actin in and Contraction of Chondrocytes, Osteoblasts, and Musculoskeletal Tissue Fibroblasts.”
2002 Clemson Award for Applied Biomaterials Research. Highest award in this category given by the Society for Biomaterials.
2004 John Charnley Award for 2004 from the Hip Society for the work entitled,
VA Research Career Scientist Award
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| Lab Members: |
Hu-Ping Hsu, M.D., Supervisor, Surgical Research
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| Courses Taught: |
Fall Terms, Harvard-MIT HST, Biomaterials-Tissue Interactions, 2.79J/3.96J/20.441J/HST.522J
Spring Terms, Haravrd-MIT HST, Cell-Matrix Mechanics, 2.785J/3.97J/20.411J/HST523J
Fall Terms, Harvard-MIT HST, Principles and Practice of Tissue Engineering, HST.535
Spring Terms, Harvard-MIT HST, Design of Medical Devices/Implants, 2.782J/3.961J/20.451J/HST.524J
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| Other Professional Activities: |
1998-2001 Guest Professor of the Department of Materials Science and Engineering, Tsinghua University, China
1991-1997 Food and Drug Administration General and Plastic Surgery Devices Advisory Panel, (Chairman, 1993-1997)
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| Keywords (MeSH): |
Glycosaminoglycans
Cartilage, Articular
Chondrocytes
Collagen
Tissue Engineering
Actins
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Publications (Pulled from Harvard Catalyst Profiles):
1. Macaya DJ, Hayakawa K, Arai K, Spector M. Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602.
2. Lim TC, Rokkappanavar S, Toh WS, Wang LS, Kurisawa M, Spector M. Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF-1a release and compatible structural support. FASEB J. 2013 Mar; 27(3):1023-33.
3. Lee IS, Spector M. The people behind the papers, and how much data is enough? Biomed Mater. 2012 Dec 1; 7(6):060201-60201.
4. Cheriyan T, Ready JE, Brick GW, Martin SD, Martin TL, Schmid TM, Padera RF, Spector M. Lubricin and smooth muscle a-actin-containing myofibroblasts in the pseudomembranes around loose hip and knee prostheses. Acta Biomater. 2013 Mar; 9(3):5751-8.
5. Cholas R, Hsu HP, Spector M. Collagen scaffolds incorporating select therapeutic agents to facilitate a reparative response in a standardized hemiresection defect in the rat spinal cord. Tissue Eng Part A. 2012 Oct; 18(19-20):2158-72.
6. Foldager CB, Kearney C, Spector M. Clinical application of extracorporeal shock wave therapy in orthopedics: focused versus unfocused shock waves. Ultrasound Med Biol. 2012 Oct; 38(10):1673-80.
7. Cheriyan T, Guo L, Orgill DP, Padera RF, Schmid TM, Spector M. Lubricin in human breast tissue expander capsules. J Biomed Mater Res B Appl Biomater. 2012 Oct; 100B(7):1961-9.
8. Elias PZ, Spector M. Characterization of a bilateral penetrating brain injury in rats and evaluation of a collagen biomaterial for potential treatment. J Neurotrauma. 2012 Jul 20; 29(11):2086-102.
9. Elias PZ, Spector M. Implantation of a collagen scaffold seeded with adult rat hippocampal progenitors in a rat model of penetrating brain injury. J Neurosci Methods. 2012 Jul 30; 209(1):199-211.
10. Kearney CJ, Hsu HP, Spector M. The use of extracorporeal shock wave-stimulated periosteal cells for orthotopic bone generation. Tissue Eng Part A. 2012 Jul; 18(13-14):1500-8.
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