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Shuichi Mizuno, PhD
Scientist, Brigham and Women's Hospital
Assistant Professor of Orthopedic Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Orthopedic Surgery
75 Francis Street
Boston, MA 02115


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Research Narrative:

Investigative Interests: Tissue Engineering, mechnophysiology, physiome


Education:
PhD

Publications (Pulled from Harvard Catalyst Profiles):

1. Ogura T, Minas T, Tsuchiya A, Mizuno S. Effects of hydrostatic pressure and deviatoric stress on human articular chondrocytes for designing neo-cartilage construct. J Tissue Eng Regen Med. 2019 Apr 09.

2. Mizuno S, Kashiwa K, Kang JD. Molecular and histological characteristics of bovine caudal nucleus pulposus by combined changes in hydrostatic and osmotic pressures in vitro. J Orthop Res. 2019 Feb; 37(2):466-476.

3. Takada E, Mizuno S. Reproduction of Characteristics of Extracellular Matrices in Specific Longitudinal Depth Zone Cartilage within Spherical Organoids in Response to Changes in Osmotic Pressure. Int J Mol Sci. 2018 May 18; 19(5).

4. Ogura T, Tsuchiya A, Minas T, Mizuno S. Optimization of Extracellular Matrix Synthesis and Accumulation by Human Articular Chondrocytes in 3-Dimensional Construct with Repetitive Hydrostatic Pressure. Cartilage. 2018 04; 9(2):192-201.

5. Mizuno S, Takada E, Fukai N. Spheroidal Organoids Reproduce Characteristics of Longitudinal Depth Zones in Bovine Articular Cartilage. Cells Tissues Organs. 2016; 202(5-6):382-392.

6. Ogura T, Tsuchiya A, Minas T, Mizuno S. Methods of high integrity RNA extraction from cell/agarose construct. BMC Res Notes. 2015 Nov 04; 8:644.

7. Ogawa R, Orgill DP, Murphy GF, Mizuno S. Hydrostatic pressure-driven three-dimensional cartilage induction using human adipose-derived stem cells and collagen gels. Tissue Eng Part A. 2015 Jan; 21(1-2):257-66.

8. Tatsumura M, Sakane M, Ochiai N, Mizuno S. Off-loading of cyclic hydrostatic pressure promotes production of extracellular matrix by chondrocytes. Cells Tissues Organs. 2013; 198(6):405-13.

9. Glowacki J, Mizuno S, Kung J, Goff J, Epperly M, Dixon T, Wang H, Greenberger JS. Effects of mouse genotype on bone wound healing and irradiation-induced delay of healing. In Vivo. 2014 Mar-Apr; 28(2):189-96.

10. Zhou S, Mizuno S, Glowacki J. Wnt pathway regulation by demineralized bone is approximated by both BMP-2 and TGF-ß1 signaling. J Orthop Res. 2013 Apr; 31(4):554-60.