Skip to contents

Charles Keith Ozaki, MD
Associate Surgeon, Brigham and Women's Hospital
Professor of Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Surgery
Vascular Surgery
75 Francis Street
Boston, MA 02115

Research Location: Thorn Research Building

Phone: 857-307-1920
Fax: 857-307-1922

Research Narrative:
The Ozaki Laboratory ( of the Division of Vascular and Endovascular Surgery broadly aims to delineate the mechanisms by which physical forces alter the morphology of the blood vessel wall.  The team holds expertise specifically in the adaptations of the vein bypass graft, an extreme example of acute perturbation of the hemodynamic environment combined with vascular trauma.  Recent investigative efforts have focused on inflammatory driven mechanisms of these adaptations.  Ongoing research directions will expand (in both animal models and humans) this foundation of knowledge via enhanced in vivo imaging of the blood vessel wall, and studies into the role of adipose related signaling networks in the longitudinal interplay between local hemodynamic factors and biologic mediators as blood vessels remodel.

Duke University, 1988, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Arnaoutakis DJ, Scully RE, Sharma G, Shah SK, Ozaki CK, Belkin M, Nguyen LL. Impact of body mass index and gender on wound complications after lower extremity arterial surgery. J Vasc Surg. 2017 Mar 01.

2. Longchamp A, Harputlugil E, Corpataux JM, Ozaki CK, Mitchell JR. Is Overnight Fasting before Surgery Too Much or Not Enough? How Basic Aging Research Can Guide Preoperative Nutritional Recommendations to Improve Surgical Outcomes: A Mini-Review. Gerontology. 2017; 63(3):228-237.

3. Ozaki CK. Invited commentary. J Vasc Surg. 2017 Jan; 65(1):206.

4. Sharma G, Wong D, Arnaoutakis DJ, Shah SK, O'Brien A, Ashley SW, Ozaki CK. Systematic identification and management of barriers to vascular surgery patient discharge time of day. J Vasc Surg. 2017 Jan; 65(1):172-178.

5. McGillicuddy EA, Ozaki CK, Shah SK, Belkin M, Hamdan A, Barshes N, Wyers M, Nguyen L. The impact of vascular surgery wound complications on quality of life. J Vasc Surg. 2016 Dec; 64(6):1780-1788.

6. Sharma G, Kulkarni R, Shah SK, King WW, Longchamp A, Tao M, Ding K, Ozaki CK. Local perivascular adiponectin associates with lower extremity vascular operative wound complications. Surgery. 2016 Jul; 160(1):204-10.

7. Madenci AL, Ozaki CK, Gupta N, Raffetto JD, Belkin M, McPhee JT. Perioperative outcomes of elective inflow revascularization for lower extremity claudication in the American College of Surgeons National Surgical Quality Improvement Program database. Am J Surg. 2016 Sep; 212(3):461-467.e2.

8. Longchamp A, Tao M, Bartelt A, Ding K, Lynch L, Hine C, Corpataux JM, Kristal BS, Mitchell JR, Ozaki CK. Surgical injury induces local and distant adipose tissue browning. Adipocyte. 2016 Apr-Jun; 5(2):163-74.

9. Koga J, Nakano T, Dahlman JE, Figueiredo JL, Zhang H, Decano J, Khan OF, Niida T, Iwata H, Aster JC, Yagita H, Anderson DG, Ozaki CK, Aikawa M. Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2343-53.

10. Longchamp A, Allagnat F, Alonso F, Kuppler C, Dubuis C, Ozaki CK, Mitchell JR, Berceli S, Corpataux JM, Déglise S, Haefliger JA. Connexin43 Inhibition Prevents Human Vein Grafts Intimal Hyperplasia. PLoS One. 2015; 10(9):e0138847.