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Charles Keith Ozaki, MD
Associate Surgeon, Brigham and Women's Hospital
Professor of Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Surgery
Vascular Surgery
75 Francis Street
Boston, MA 02115

Research Location: Thorn Research Building

Phone: 857-307-1920
Fax: 857-307-1922

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Research Narrative:
The Ozaki Laboratory ( of the Division of Vascular and Endovascular Surgery broadly aims to delineate the mechanisms by which physical forces alter the morphology of the blood vessel wall.  The team holds expertise specifically in the adaptations of the vein bypass graft, an extreme example of acute perturbation of the hemodynamic environment combined with vascular trauma.  Recent investigative efforts have focused on inflammatory driven mechanisms of these adaptations.  Ongoing research directions will expand (in both animal models and humans) this foundation of knowledge via enhanced in vivo imaging of the blood vessel wall, and studies into the role of adipose related signaling networks in the longitudinal interplay between local hemodynamic factors and biologic mediators as blood vessels remodel.

Duke University, 1988, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Kip P, Trocha KM, Tao M, O'leary JJ, Ruske J, Giulietti JM, Trevino-Villareal JH, MacArthur MR, Bolze A, Burak MF, Patterson S, Ho KJ, Carmody RN, Guzman RJ, Mitchell JR, Ozaki CK. Insights From a Short-Term Protein-Calorie Restriction Exploratory Trial in Elective Carotid Endarterectomy Patients. Vasc Endovascular Surg. 2019 Aug; 53(6):470-476.

2. Trocha KM, Kip P, Tao M, MacArthur MR, Treviño-Villarreal H, Longchamp A, Toussaint W, Lambrecht BN, de Vries MR, Quax PHA, Mitchell JR, Ozaki CK. Short-Term Preoperative Protein Restriction Attenuates Vein Graft Disease via Induction of Cystathionine ?-Lyase. Cardiovasc Res. 2019 Mar 29.

3. McGlynn PK, Arnaoutakis KD, Deroo EP, Ozaki CK, Forman JP, Hentschel DM. Postanesthesia ultrasound facilitates creation of more preferred accesses without affecting access survival. J Vasc Surg. 2019 Mar; 69(3):898-905.

4. Bleyer AJ, Scavo VA, Wilson SE, Browne BJ, Ferris BL, Ozaki CK, Lee T, Peden EK, Dixon BS, Mishler R, O'Connor TP, Kidd K, Burke SK. A randomized trial of vonapanitase (PATENCY-1) to promote radiocephalic fistula patency and use for hemodialysis. J Vasc Surg. 2019 02; 69(2):507-515.

5. Ozaki CK. Invited commentary. J Vasc Surg. 2018 12; 68(6S):220S-221S.

6. Trocha K, Kip P, MacArthur MR, Mitchell SJ, Longchamp A, Treviño-Villarreal JH, Tao M, Bredella MA, De Amorim Bernstein K, Mitchell JR, Ozaki CK. Preoperative Protein or Methionine Restriction Preserves Wound Healing and Reduces Hyperglycemia. J Surg Res. 2019 Mar; 235:216-222.

7. Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms. JCI Insight. 2018 11 02; 3(21).

8. de Vries MR, Parma L, Peters HAB, Schepers A, Hamming JF, Jukema JW, Goumans MJTH, Guo L, Finn AV, Virmani R, Ozaki CK, Quax PHA. Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels. J Intern Med. 2019 Jan; 285(1):59-74.

9. Leak RK, Calabrese EJ, Kozumbo WJ, Gidday JM, Johnson TE, Mitchell JR, Ozaki CK, Wetzker R, Bast A, Belz RG, Bøtker HE, Koch S, Mattson MP, Simon RP, Jirtle RL, Andersen ME. Enhancing and Extending Biological Performance and Resilience. Dose Response. 2018 Jul-Sep; 16(3):1559325818784501.

10. Sharma G, Scully RE, Shah SK, Madenci AL, Arnaoutakis DJ, Menard MT, Ozaki CK, Belkin M. Thirty-year trends in aortofemoral bypass for aortoiliac occlusive disease. J Vasc Surg. 2018 12; 68(6):1796-1804.e2.