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Dennis Paul Orgill, MD, PhD
Senior Surgeon, Brigham and Women's Hospital
Professor of Surgery, Harvard Medical School

Brigham and Women's Hospital
Department of Surgery
Plastic Surgery
75 Francis Street
Boston, MA 02115

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Research Narrative:

Dr. Orgill's research team members include Matthew Carty M.D., Kendra Bowman M.D., James Watkins, M.D. as well as Daniel Snow, Ph.D. and Robert Huckman, Ph.D. of the Harvard Business School. They are also collaborating with Dr. Caprice Greenberg to quantitatively analyze videos of young attendings, residents and students doing surgery to provide time-motion analysis of surgical techniques.

Electronic medical records and in process clinical data provide an untapped resource to improve quality and efficiency in surgery. Although large amounts of data are collected, these are most often not looked at with a critical eye for process improvement. His team believes that advanced mathematical analysis applied to these data sets will allow a robust method for improvement of quality and efficiency.

They are currently using Statistical Process Control methodology to study learning curves in surgery. Last year Dr. Orgill's team published a paper in Plastic and Reconstructive Surgery, where they showed that over about a 12 year time period, surgeons could improve their variance in operative time and efficiency in the operating room while having less complications. They are currently applying this learning model to other procedures including laparoscopic cholecystectomy, coronary artery bypass grafting, total knee replacement and septoplasty.


Publications (Pulled from Harvard Catalyst Profiles):

1. Giatsidis G, Succar J, Waters TD, Liu W, Rhodius P, Wang C, Nilsen TJ, Chnari E, Orgill DP. Tissue Engineered Soft Tissue Reconstruction Using Non-invasive Mechanical Preconditioning and a Shelf-ready Allograft Adipose Matrix. Plast Reconstr Surg. 2019 Jul 03.

2. Christensen JM, Orgill DP. Discussion: The Interplay of Mechanical Stress, Strain, and Stiffness at the Keloid Periphery Correlates with Increased Caveolin-1/ROCK Signaling and Scar Progression. Plast Reconstr Surg. 2019 Jul; 144(1):68e-69e.

3. Orgill DP. Response to Drs. Hua and Wei. Plast Reconstr Surg. 2019 Jul 01.

4. Icli B, Wu W, Ozdemir D, Li H, Cheng HS, Haemmig S, Liu X, Giatsidis G, Avci SN, Lee N, Guimaraes RB, Manica A, Marchini JF, Rynning SE, Risnes I, Hollan I, Croce K, Yang X, Orgill DP, Feinberg MW. MicroRNA-615-5p Regulates Angiogenesis and Tissue Repair by Targeting AKT/eNOS (Protein Kinase B/Endothelial Nitric Oxide Synthase) Signaling in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2019 Jul; 39(7):1458-1474.

5. Sood RF, Orgill DP. Discussion: An Assessment of Bleeding Complications Necessitating Blood Transfusion across Inpatient Plastic Surgery Procedures: A Nationwide Analysis Using the National Surgical Quality Improvement Program Database. Plast Reconstr Surg. 2019 05; 143(5):1118e-1119e.

6. Uehara M, Li X, Sheikhi A, Zandi N, Walker B, Saleh B, Banouni N, Jiang L, Ordikhani F, Dai L, Yonar M, Vohra I, Kasinath V, Orgill DP, Khademhosseini A, Annabi N, Abdi R. Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival. Sci Rep. 2019 Apr 25; 9(1):6535.

7. Kim PJ, Attinger CE, Orgill D, Galiano RD, Steinberg JS, Evans KK, Lavery LA. Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry. Plast Reconstr Surg Glob Open. 2019 Apr; 7(4):e2129.

8. Roh DS, Orgill DP. Discussion: The Preparation of the Recipient Site in Fat Grafting: A Comprehensive Review of the Preclinical Evidence. Plast Reconstr Surg. 2019 04; 143(4):1108-1110.

9. Taylor EM, Orgill DP. Discussion: Quality and Quantity-Cultured Murine Endothelial Progenitor Cells Increase Vascularization and Decrease Fibrosis in the Fat Graft. Plast Reconstr Surg. 2019 04; 143(4):756e-757e.

10. Tappenbeck N, Schröder HM, Niebergall-Roth E, Hassinger F, Dehio U, Dieter K, Kraft K, Kerstan A, Esterlechner J, Frank NY, Scharffetter-Kochanek K, Murphy GF, Orgill DP, Beck J, Frank MH, Ganss C, Kluth MA. In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials. Cytotherapy. 2019 May; 21(5):546-560.