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George R. Washko, Jr., MMSc, MD
Associate Physician, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Pulmonary
75 Francis Street
Boston, MA 02115


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Research Narrative:

I am a clinical investigator in Chronic Obstructive Pulmonary Disease with a focus in imaging and quantitative image analysis.  I have been on staff for approximately 6 years and have been awarded a K23 Mentored Career Development Award with the aims of developing image based biomarkers for airway disease in smokers.  In addition to my K23, I am one 10 national PIs of the NHLBI funded COPD Clinical Research Networks.    The goal of this network is to find therapies for the treatment and/or prevention of acute exacerbations of COPD.  We recently completed a multicenter randomized placebo controlled trial of azithromycin and published the results in the NEJM.  In addition to my clinical research, I maintain an imaging group focused on Computed Tomographic characterization of lung disease.  In addition to our role as one of the image analysis sites in the COPDGene Study, we are the image analysis center for the Framingham Heart Study Pulmonary Research Center.  To date we have processed over 30,000 CT scans of the chest between the COPDGene and FHS projects.  Finally, I have an ancillary clinical studies R01 whose aims are focused on the CT based assessment of smoking related lung disease in the COPD CRN statin trial and we are actively recruiting study subjects across North America.


Education:
Harvard Medical School, 2006, MMSc
Georgetown University School of Medicine, 1999, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Rahaghi FN, Winkler T, Kohli P, Nardelli P, Martí-Fuster B, Ross JC, Radhakrishnan R, Blackwater T, Ash SY, de La Bruere I, Diaz AA, Channick RN, Harris RS, Washko GR, San José Estépar R. Quantification of the Pulmonary Vascular Response to Inhaled Nitric Oxide Using Noncontrast Computed Tomography Imaging. Circ Cardiovasc Imaging. 2019 Dec; 12(1):e008338.

2. Rice MB, Li W, Schwartz J, Di Q, Kloog I, Koutrakis P, Gold DR, Hallowell RW, Zhang C, O'Connor G, Washko GR, Hunninghake GM, Mittleman MA. Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: the Framingham Heart Study. Thorax. 2019 Aug 07.

3. Washko GR, Colangelo LA, Estépar RSJ, Ash SY, Bhatt SP, Okajima Y, Liu K, Iribarren C, Thyagarajan BT, Lewis CE, Kumar R, Han MK, Dransfield MT, Kalhan R. Adult Life-Course Trajectories of Lung Function and the Development of Emphysema: The CARDIA Lung Study. Am J Med. 2019 Jul 29.

4. Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San José Estépar R, Zhou X, Castaldi PJ. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 Jul 25; 8.

5. Hobbs BD, Putman RK, Araki T, Nishino M, Gudmundsson G, Gudnason V, Eiriksdottir G, Zilhao Nogueira NR, Dupuis J, Xu H, O'Connor GT, Manichaikul A, Nguyen J, Podolanczuk AJ, Madahar P, Rotter JI, Lederer DJ, Barr RG, Rich SS, Ampleford EJ, Ortega VE, Peters SP, O'Neal WK, Newell JD, Bleecker ER, Meyers DA, Allen RJ, Oldham JM, Ma SF, Noth I, Jenkins RG, Maher TM, Hubbard RB, Wain LV, Fingerlin TE, Schwartz DA, Washko GR, Rosas IO, Silverman EK, Hatabu H, Cho MH, Hunninghake GM. Overlap of Genetic Risk Between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 Jul 24.

6. Putman RK, Gudmundsson G, Axelsson GT, Hida T, Honda O, Araki T, Yanagawa M, Nishino M, Miller ER, Eiriksdottir G, Gudmundsson EF, Tomiyama N, Honda H, Rosas IO, Washko GR, Cho MH, Schwartz DA, Gudnason V, Hatabu H, Hunninghake GM. Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality. Am J Respir Crit Care Med. 2019 Jul 15; 200(2):175-183.

7. Washko GR, Agusti A. Heart and lungs in a single breath. Respirology. 2019 Jul 11.

8. Synn AJ, Li W, San José Estépar R, Zhang C, Washko GR, O'Connor GT, Araki T, Hatabu H, Bankier AA, Mittleman MA, Rice MB. Radiographic Pulmonary Vessel Volume, Lung Function, and Airways Disease in the Framingham Heart Study. Eur Respir J. 2019 Jul 04.

9. Harmouche R, Ash SY, Putman RK, Hunninghake GM, San Jose Estepar R, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Han MK, Bowler RP, Kalhan R, Rosas IO, Washko GR, San Jose Estepar R. Objectively Measured Chronic Lung Injury on Chest CT. Chest. 2019 Jun 22.

10. Rahaghi FN, Argemí G, Nardelli P, Domínguez-Fandos D, Arguis P, Peinado VI, Ross JC, Ash S, de La Bruere I, Come CE, Diaz AA, Sánchez M, Washko GR, Barberà JA, San José Estépar R. Pulmonary Vascular Density: Comparison of Findings on CT Imaging with Histology. Eur Respir J. 2019 Jun 13.