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Peter H. Stone, MD
Senior Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Cardiovascular
75 Francis Street
Boston, MA 02115


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Research Narrative:

Dr. Peter Stone 's research interests focus on a variety of aspects concerning coronary artery disease, from understanding the basic and clinical vascular biology of atherosclerosis progression in animals and in man, to investigating new pharmacologic and device therapies for patients with acute and chronic coronary artery disease.

A major focus of his work has been to understand the hemodynamic influences on vascular biology responsible for the progression of coronary atherosclerosis in man, to develop in-vivo methodologies to enable the identification of the sites where coronary atherosclerosis and “vulnerable plaque” will progress, and to investigate the clinical benefits resulting from early identification of high-risk lesions. The ultimate goal of these investigations is to create a new paradigm for management of coronary artery disease, whereby individual high-risk coronary lesions will be identified early in their natural history by vascular profiling of local endothelial shear stress and patterns of vascular remodeling. Identification of these high-risk lesions would enable utilization of highly selective pre-emptive interventions to avert subsequent adverse cardiac events.

He has also been pursuing clinical investigations of new anti-ischemic therapies for patients with coronary artery disease as well as investigating the use of ambulatory ECG (AECG or Holter) monitoring to evaluate transient episodes of ST-segment deviation.

Dr. Stone has been the Director of the AECG Core Laboratory for a number of multicenter clinical trials sponsored by the NHLBI or by industry. He has been investigating the significance of T-wave alternans during ischemic episodes identified from AECG monitoring.  These electrophysiologic phenomena may identify patients at increased risk of arrhythmic events associated with ischemia.  His AECG Laboratory is also evaluating the cardiac effects of air pollution on high-risk coronary patients using measures of heart rate variability and myocardial ischemia.


Education:
Cornell University Medical College, 1974, MD

Publications (Pulled from Harvard Catalyst Profiles):

1. Stone PH. The Hazardous Longitudinal Heterogeneity of Plaques: A Complex Mountain Range, Not a Single Volcano. JACC Cardiovasc Imaging. 2019 Jul 11.

2. Won KB, Lee SE, Lee BK, Park HB, Heo R, Rizvi A, Hadamitzky M, Kim YJ, Sung JM, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Choi JH, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ. Longitudinal quantitative assessment of coronary plaque progression related to body mass index using serial coronary computed tomography angiography. Eur Heart J Cardiovasc Imaging. 2019 May 01; 20(5):591-599.

3. Andreou I, Stone PH, Ikonomidis I, Alexopoulos D, Sabaté M. Recurrent atherosclerosis complications as a mechanism for stent failure. Hellenic J Cardiol. 2019 Apr 26.

4. Stone PH. Evaluation of individual plaque risk based on plaque anatomic and biomechanical characteristics: methodologies and clinical applications are approaching an inflection point. Eur Heart J. 2019 Apr 21.

5. Stone PH, Fotiadis DI. Enhanced Multifactorial Biomechanical Stress Metrics to Predict Plaque Rupture: Rapid Assessment of Morphology and Plaque Structural Stress. JACC Cardiovasc Imaging. 2019 Apr 10.

6. Lee SE, Sung JM, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Kumar A, Lee BK, Leipsic JA, Maffei E, Marques H, Pontone G, Raff G, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ. Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study. Eur Heart J Cardiovasc Imaging. 2019 Feb 20.

7. Won KB, Lee SE, Lee BK, Park HB, Heo R, Rizvi A, Lin FY, Kumar A, Hadamitzky M, Kim YJ, Sung JM, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Raff GL, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ. Longitudinal assessment of coronary plaque volume change related to glycemic status using serial coronary computed tomography angiography: A PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) substudy. J Cardiovasc Comput Tomogr. 2019 Mar - Apr; 13(2):142-147.

8. Siasos G, Tsigkou V, Zaromytidou M, Sara JD, Varshney A, Coskun AU, Lerman A, Stone PH. Role of local coronary blood flow patterns and shear stress on the development of microvascular and epicardial endothelial dysfunction and coronary plaque. Curr Opin Cardiol. 2018 11; 33(6):638-644.

9. Stone PH, Coskun AU, Croce KJ. Evolving insights into the role of local shear stress in late stent failure from neoatherosclerosis formation and plaque destabilization. Int J Cardiol. 2018 12 01; 272:45-46.

10. Lee SE, Sung JM, Rizvi A, Lin FY, Kumar A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Hyun Choi J, Chinnaiyan K, Raff G, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ. Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease. Circ Cardiovasc Imaging. 2018 07; 11(7):e007562.