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Richard Leslie Stevens
Senior Immunologist, Brigham and Women's Hospital
Professor of Medicine, Emeritus, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Rheumatology, Immunology
75 Francis Street
Boston, MA 02115


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Research Narrative:

Investigative Interests: Mast Cell, Protease, Proteoglycans, Inflammation, Connective Tissue Remodeling


Resources:
Mast Cell Specific Assays, Phage Display Technology

Publications (Pulled from Harvard Catalyst Profiles):

1. Stevens RL, McNeil HP, Wensing LA, Shin K, Wong GW, Hansbro PM, Krilis SA. Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5. J Biol Chem. 2017 03 31; 292(13):5392-5404.

2. Sheppard JP, Stevens R, Gill P, Martin U, Godwin M, Hanley J, Heneghan C, Hobbs FD, Mant J, McKinstry B, Myers M, Nunan D, Ward A, Williams B, McManus RJ. Predicting Out-of-Office Blood Pressure in the Clinic (PROOF-BP): Derivation and Validation of a Tool to Improve the Accuracy of Blood Pressure Measurement in Clinical Practice. Hypertension. 2016 May; 67(5):941-50.

3. Zhou S, Tanaka K, O'Keeffe M, Qi M, El-Assaad F, Weaver JC, Chen G, Weatherall C, Wang Y, Giannakopoulos B, Chen L, Yu D, Hamilton MJ, Wensing LA, Stevens RL, Krilis SA. CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide. PLoS One. 2016; 11(3):e0151638.

4. Kono M, Yasuda S, Stevens RL, Koide H, Kurita T, Shimizu Y, Kanetsuka Y, Oku K, Bohgaki T, Amengual O, Horita T, Shimizu T, Majima T, Koike T, Atsumi T. Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation. Arthritis Rheumatol. 2015 Feb; 67(2):396-407.

5. Hamilton MJ, Frei SM, Stevens RL. The multifaceted mast cell in inflammatory bowel disease. Inflamm Bowel Dis. 2014 Dec; 20(12):2364-78.

6. Wong GW, Zhuo L, Kimata K, Lam BK, Satoh N, Stevens RL. Ancient origin of mast cells. Biochem Biophys Res Commun. 2014 Aug 22; 451(2):314-8.

7. Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, Frei SM, Wong GW, Hamadi S, Zhou S, Foster PS, Krilis SA, Stevens RL. Importance of mast cell Prss31/transmembrane tryptase/tryptase-? in lung function and experimental chronic obstructive pulmonary disease and colitis. J Biol Chem. 2014 Jun 27; 289(26):18214-27.

8. Prieto-García A, Castells MC, Hansbro PM, Stevens RL. Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation. Immunol Allergy Clin North Am. 2014 May; 34(2):263-81.

9. Bankova LG, Lezcano C, Pejler G, Stevens RL, Murphy GF, Austen KF, Gurish MF. Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15; 192(6):2812-20.

10. Farmer AJ, Stevens R, Hirst J, Lung T, Oke J, Clarke P, Glasziou P, Neil A, Dunger D, M Colhoun H, Pugh C, Wong G, Perera R, Shine B. Optimal strategies for identifying kidney disease in diabetes: properties of screening tests, progression of renal dysfunction and impact of treatment - systematic review and modelling of progression and cost-effectiveness. Health Technol Assess. 2014 Feb; 18(14):1-128.