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Edwin Kepner Silverman, MD, PhD
Physician, Brigham and Women's Hospital
Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Channing Division of Network Medicine
75 Francis Street
Boston, MA 02115


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Research Narrative:

I am a pulmonologist and genetic epidemiologist working on a variety of respiratory genetic epidemiology studies. For the past eighteen years, I have been the Principal Investigator of an extended pedigree study designed to identify novel genetic determinants of early-onset COPD (Boston Early-Onset COPD Study). I am currently leading two multicenter COPD genetics studies which include genome-wide association analysis. I am the Principal Investigator of the Transcontinental COPD Genetics Study, which is investigating genetic determinants of COPD in diverse ethnic groups, and I am one of two Principal Investigators of the Genetic Epidemiology of COPD Study (COPDGene), which has created a large cohort of COPD cases and controls with comprehensive pulmonary phenotyping (including chest CT scans) for genome-wide association analysis. I was also the Principal Investigator of the Alpha-1 Antitrypsin Genetic Modifiers Study. I am also collaborating on several other studies of COPD genetics, including the International COPD Genetics Network (I am one of the two Principal Investigators) and the ECLIPSE Study (I am on the Steering Committee). I am the Director of the BWH Respiratory Genetics Research Center, which is focused on identifying the functional impact of COPD loci identified by genetic association studies. I have mentored seventeen post-doctoral fellows.

As the Chief of the Channing Division of Network Medicine, I am working to develop and extend our research and educational efforts in the application of systems biology approaches to complex diseases.


Education:
Washington University School of Medicine, 1990, MD-PhD

Publications (Pulled from Harvard Catalyst Profiles):

1. Regan EA, Hersh CP, Castaldi PJ, DeMeo DL, Silverman EK, Crapo JD, Bowler RP. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 Aug; 61(2):143-149.

2. Parker MM, Hao Y, Guo F, Pham B, Chase R, Platig J, Cho MH, Hersh CP, Thannickal VJ, Crapo J, Washko G, Randell SH, Silverman EK, San José Estépar R, Zhou X, Castaldi PJ. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 Jul 25; 8.

3. Regan EA, Lowe KE, Make BJ, Lynch DA, Kinney GL, Budoff MJ, Mao SS, Dyer D, Curtis JL, Bowler RP, Han MK, Beaty TH, Hokanson JE, Kern E, Humphries S, Curran-Everett D, van Beek EJR, Silverman EK, Crapo JD, Finigan JH. Identifying Smoking-Related Disease on Lung Cancer Screening CT Scans: Increasing the Value. Chronic Obstr Pulm Dis. 2019 Jul 24; 6(3):233-245.

4. Hobbs BD, Putman RK, Araki T, Nishino M, Gudmundsson G, Gudnason V, Eiriksdottir G, Zilhao Nogueira NR, Dupuis J, Xu H, O'Connor GT, Manichaikul A, Nguyen J, Podolanczuk AJ, Madahar P, Rotter JI, Lederer DJ, Barr RG, Rich SS, Ampleford EJ, Ortega VE, Peters SP, O'Neal WK, Newell JD, Bleecker ER, Meyers DA, Allen RJ, Oldham JM, Ma SF, Noth I, Jenkins RG, Maher TM, Hubbard RB, Wain LV, Fingerlin TE, Schwartz DA, Washko GR, Rosas IO, Silverman EK, Hatabu H, Cho MH, Hunninghake GM. Overlap of Genetic Risk Between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 Jul 24.

5. Kim W, Cho MH, Sakornsakolpat P, Lynch DA, Coxson HO, Tal-Singer R, Silverman EK, Beaty TH. DSP variants may be associated with longitudinal change in quantitative emphysema. Respir Res. 2019 Jul 19; 20(1):160.

6. Halu A, Liu S, Baek SH, Hobbs BD, Hunninghake GM, Cho MH, Silverman EK, Sharma A. Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Hum Mol Genet. 2019 Jul 15; 28(14):2352-2364.

7. Moore C, Blumhagen RZ, Yang IV, Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, Markin CR, Mathai SK, Schwarz MI, Steele MP, Lee J, Brown KK, Loyd JE, Crapo JD, Silverman EK, Cho MH, James JA, Guthridge JM, Cogan JD, Kropski JA, Swigris JJ, Bair C, Kim DS, Ji W, Kim H, Song JW, Maier LA, Pacheco KA, Hirani N, Poon AS, Li F, Jenkins RG, Braybrooke R, Saini G, Maher TM, Molyneaux PL, Saunders P, Zhang Y, Gibson KF, Kass DJ, Rojas M, Sembrat J, Wolters PJ, Collard HR, Sundy JS, O'Riordan T, Strek ME, Noth I, Ma SF, Porteous MK, Kreider ME, Patel NB, Inoue Y, Hirose M, Arai T, Akagawa S, Eickelberg O, Fernandez IE, Behr J, Mogulkoc N, Corte TJ, Glaspole I, Tomassetti S, Ravaglia C, Poletti V, Crestani B, Borie R, Kannengiesser C, Parfrey H, Fiddler C, Rassl D, Molina-Molina M, Machahua C, Worboys AM, Gudmundsson G, Isaksson HJ, Lederer DJ, Podolanczuk AJ, Montesi SB, Bendstrup E, Danchel V, Selman M, Pardo A, Henry MT, Keane MP, Doran P, Vašáková M, Sterclova M, Ryerson CJ, Wilcox PG, Okamoto T, Furusawa H, Miyazaki Y, Laurent G, Baltic S, Prele C, Moodley Y, Shea BS, Ohta K, Suzukawa M, Narumoto O, Nathan SD, Venuto DC, Woldehanna ML, Kokturk N, de Andrade JA, Luckhardt T, Kulkarni T, Bonella F, Donnelly SC, McElroy A, Armstong ME, Aranda A, Carbone RG, Puppo F, Beckman KB, Nickerson DA, Fingerlin TE, Schwartz DA. Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 Jul 15; 200(2):199-208.

8. Park J, Hobbs BD, Crapo JD, Make BJ, Regan EA, Humphries S, Carey VJ, Lynch DA, Silverman EK. Subtyping COPD using visual and quantitative CT features. Chest. 2019 Jul 05.

9. Saferali A, Yun JH, Parker MM, Sakornsakolpat P, Chase RP, Lamb A, Hobbs BD, Boezen MH, Dai X, de Jong K, Beaty TH, Wei W, Zhou X, Silverman EK, Cho MH, Castaldi PJ, Hersh CP. Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. PLoS Genet. 2019 Jul; 15(7):e1008229.

10. Kim W, Giannikou K, Dreier JR, Lee S, Tyburczy ME, Silverman EK, Radzikowska E, Wu S, Wu CL, Henske EP, Hunninghake G, Carel H, Roman A, Pujana MA, Moss J, Won S, Kwiatkowski DJ. A genome-wide association study implicates NR2F2 in lymphangioleiomyomatosis pathogenesis. Eur Respir J. 2019 Jun; 53(6).