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Yujiang Shi, Ph.D.
Associate Biochemist, Brigham and Women's Hospital
Associate Professor of Medicine, Harvard Medical School

Brigham and Women's Hospital
Department of Medicine
Endocrinology
75 Francis Street
Boston, MA 02115


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Research Narrative:

Dr. Shi is exploring novel epigenetic mechanisms involved in regulation of eukaryotic gene expression with the goal of identifying and characterizing these novel epigenetic players to better understand the mechanisms in chromatin. Among his several accomplishments, Dr. Shi has isolated and characterized the first histone demethylase (LSD1). The discovery of this long sought enzyme opened new ground in the emerging and fast moving epigenetic field. He is focusing on identifying novel cellular targets of LSD1 and investigating the dynamic regulation of histone methylation by LSD1 in vivo using LSD1-knockout murine model. He is also investigating whether LSD1 activity is regulated by its associated partners such as transcriptional corepressors and whether there is interplay between histone deacetylases and demethylases in the LSD1 complex during silencing of target genes, such as the angiotensinogen gene.


Education:
U. of Florida , 2000, Ph.D.

Publications (Pulled from Harvard Catalyst Profiles):

1. Clark EA, Wu F, Chen Y, Kang P, Kaiser UB, Fang R, Shi YG. GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers. Cell Rep. 2019 Jun 18; 27(12):3522-3532.e3.

2. Jin Y, Ma D, Gramyk T, Guo C, Fang R, Ji H, Shi YG. Kdm1a promotes SCLC progression by transcriptionally silencing the tumor suppressor Rest. Biochem Biophys Res Commun. 2019 Jul 12; 515(1):214-221.

3. Ma H, Wang X, Cai J, Dai Q, Natchiar SK, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Klaholz BP, Pan T, Shi Y, He C. Publisher Correction: N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat Chem Biol. 2019 05; 15(5):549.

4. Chen H, Yu D, Fang R, Rabidou K, Wu D, Hu D, Jia P, Zhao Z, Wu Z, Peng J, Shi Y, Shi YG. TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer. Cell Res. 2019 Mar; 29(3):248-250.

5. Ma H, Wang X, Cai J, Dai Q, Natchiar SK, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Klaholz BP, Pan T, Shi Y, He C. N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat Chem Biol. 2019 01; 15(1):88-94.

6. Liu L, Shen Y, Zhu X, Lv R, Li S, Zhang Z, Shi YG, Tan L. ERa is a negative regulator of PD-L1 gene transcription in breast cancer. Biochem Biophys Res Commun. 2018 10 20; 505(1):157-161.

7. Wu D, Hu D, Chen H, Shi G, Fetahu IS, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian CG, Murphy GF, Adler GK, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 2018 07; 559(7715):637-641.

8. Wen J, Lv R, Ma H, Shen H, He C, Wang J, Jiao F, Liu H, Yang P, Tan L, Lan F, Shi YG, He C, Shi Y, Diao J. Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal. Mol Cell. 2018 03 15; 69(6):1028-1038.e6.

9. Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V. Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. 2017 11 14; 9(5):1721-1734.

10. Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F, Shi Y. Nono, a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency. Cell Rep. 2016 10 18; 17(4):997-1007.